Ramatroban results thread

Stem cell; cell based hair therapy
81

There is a guy on HLH that is shedding very bad on Indo and Ramatroban, but he is also suffering from flaky scalp, redness, soreness i.e a severe reaction to the formula that isn’t subsiding. In his case, he may well be allergic to DMSO, or it is too harsh for his scalp.

Unless you are having this kind of obvious and severe allergic reaction, perhaps you can assume that the formula must be having an effect on your hair follicles, I just can’t see why/how it would be a bad one.

82

I used only Ramatroban and Cloprostenol for bout 3 weeks, didn’t like the results. I do a lot better on just indo/chrom and minox

83

Well Well Well…
Ok guyz its seems that the shedding on my hairline has stopped, I clearly have some little new hair on the front, i ordred another bottle of indo/chromo, and i think that after it i will be fixed about the efficiency of the drug.
For the moment, the only fact is that i had a shedding trought it, with a big hit on my left side, like 1 cm reeceded in just few weeks.
I will take you all inform about the situation.

84

that is what is working best for me, chromo/indo only. I quit the ramatroban and cloprostenol.

85

Just a quick update,
Shedding on ramatroban has definitely stabilised, getting some regrowth, small dark hairs growing back in problem areas. Also, similar to what people report on indo/chromo, my scalp is looking healthy, hairs stronger and no itching. Been on it almost 2 months now.

86

i want to say two words
im reading that this thread is about
<< ramatroban thread only>> and you write mostly for indomethacin and chromoglycate.
Is being very confusing
you are starting a medicine and after two three weeks you stop it for something else because of shed or you say that didnt work, how do you know that a med doesnt work in so little time
you dont know that sheding is a good sign that the med is working???
my brother have a terrible shed on fin and minox for the first two months but after he had a huge regrowth
in every regimen that we try all these years in these forums we say some standart rules and one of these is that YOU HAVE TO GIVE YOUR REGIMEN TIME( at least six months) BEFORE YOU JUDGE IT

87

i agree that when it comes to hair giving each personal trial a solid 6 months is a good idea (as long as there is some scientific credence to trying the drug in the first place), and that initial shedding is likely a good thing. i’ve been coming to this site since 2002, and that topic used to come up all the time when everybody was using fin and anticipating dut. basically just here at this point to echo jgray with this:

I’m on month 3 of ramatroban - 3 squirts 2x daily. after what was a pretty mild initial shed i now might be seeing some darker hairs along my rather sizable temples and right in the front where my widows peak used to be. my scalp feels good as well; no issues with redness/irritation/flaking or anything like that. it’s pretty sweet - very mild improvement at this point but i’m looking forward to seeing what happens over the next 9 months or so. i’m not planning on taking pics but i’ll post every month to let you guys know how the dome is coming along

88

I did not give up dude, I am pretty confident about this shedding, even if is very horrible. I am fed up about the guyz who can’t ride out the sheds and claim shlt about the drugs(not only pgd2).
By blocking the PGD2, we target precisly the inflammatory problem of the hair follicule in the MPB process wich is for me the major ennemy of this disease, we just can not expect to avoid sheds. Shedding is a pretty good thing and i am convinced that the hairs will come back, i don’t talk about the bald scalp, but the hairs shedded the past weeks.

89

If drugs for fighting hairloss would make u bald faster, it would be like eating macdonalds every day and be as skinny as a model…no sense.
Just stick with the drug, and don’t give up.

90

It’s good to hear that you’re in the same boat as me, it certainly confounds my view that ramatroban is helping - despite an initial shed. As it’s such a new treatment there is a lot of uncertainty since we have few people to compare and contrast experiences. I will certainly continue treatment for at least six months.

91

I am still shedding after one month of consistent use and i’m considering adding a dht-blocker to be safe.

The reason why people quit after a few months of shedding is because they fear the drug is not working. In the case of I/C where you have people saying “I stopped losing hair instantly” it suggests that, a month after using it, it’s not working if your hair is still falling out. I/C is not Fin or Dut, it’s an experimental and unproven. I do not want to lose what precious hair I have left if my results aren’t like the majority of people. That’s why I am considering adding a more proven treatment after next month. No way you should shed for 8 weeks straight and not regain, that’s not a good sign. Sheds normally take at the most 1 month for your hair to cycle, then your hair should start feeling thicker. I’m losing hair and it’s not coming back in the crown, just looks like I’m going bald, plain and simple. On the hairline there are lots of tiny vellus hair, some getting thicker and some not.

I just want to write this because my hair loss has not stopped and people should have as much data as possible, not just assume that everyone will stop shedding in days or even a couple weeks

92

HI all,

just joined the forum to give my anecdotal observations (I know these are not worth a lot, but I still find it remarkable). I have been taking ibuprofen for an injury I have and my shedding is almost non-existent. I am obsessed with my hair like probably most are here so I notice the shedding, the amount of hair in the comb after showering etc…and the differnce is very clear and very big.

I have been on fin now for almost 8 years, it maintains my hair.
You can read my story here (just substitute the ** for ai:

http://www.h**rlosstalk.com/interact/showthread.php/15570-Damnthis-Story-(7-years-on-fin-diffuse-with-pics(05-2007)

My question is: I know the chromo and the indo and the ramatroban are somehow related to the ibuprofen. I am a difuse thinner and was always interested by the inflamation-aspect of hairloss etc… I can’t keep taking ibuprofen indefintely (certainly not systemically) but would like to substitute it with on of the other products which are used topically by you guys however what are the consequences of taking them longterm?

Also can someone iluminate me on the connection between ibuprofen and these other products

93

[quote][postedby]Originally Posted by damnthis[/postedby]
HI all,

just joined the forum to give my anecdotal observations (I know these are not worth a lot, but I still find it remarkable). I have been taking ibuprofen for an injury I have and my shedding is almost non-existent. I am obsessed with my hair like probably most are here so I notice the shedding, the amount of hair in the comb after showering etc…and the differnce is very clear and very big.

I have been on fin now for almost 8 years, it maintains my hair.
You can read my story here (just substitute the ** for ai:

http://www.h**rlosstalk.com/interact/showthread.php/15570-Damnthis-Story-(7-years-on-fin-diffuse-with-pics(05-2007)

My question is: I know the chromo and the indo and the ramatroban are somehow related to the ibuprofen. I am a difuse thinner and was always interested by the inflamation-aspect of hairloss etc… I can’t keep taking ibuprofen indefintely (certainly not systemically) but would like to substitute it with on of the other products which are used topically by you guys however what are the consequences of taking them longterm?

Also can someone iluminate me on the connection between ibuprofen and these other products[/quote]

The connecion betweem ibuprofen, diclofenac, and indomethacin, is that they all are COX inhibitors. COX is an enzime in charge of producing prostaglandines. The thing is, according to recent studies, apparently PGD2 (one of this prostaglandines) has a crucial role on the process of male pattern baldness. Let’s say, PGD2 seems to be another part of the chain, a chain which gets started with DHT. And this is the reason why some of us believe this could work.

Anyway, even though diclofenac and ibuprofen are COX inhibitors just like indomethacin, indomethacin is sitll supposed to be a little bit better than those, as indomethacin is also a week PGD2 agonist with a PGD2 antoagonist effect.

Taking this products in oral form could be pretty dangerous on the long run, but used in topical form is supposed to be harmless. Indomethacin in cream form or spray, or diclofenac or ibuprofen in gel form have been used for years to treat pain and inflammation, they are pretty safe.

Now, to my knowledge, the iron-dragon indomethacin formula may not be so safe, as it uses a vehicle wich allows to much of the main substance to get inside the sistem, and that could be a problem.

94

Thanks for the reply, I will wait a bit longere before adding one of these products.

95

Osma, the dosage applied topically of indo/chromo even from irondragon is faaaaar to low to causes serious problem(like some kidney issues etc…), the only troubles that you can get is the usual ones(redness, itching etc…).

96

One more thing:

How come the only info you can find is that for example ibuprofen can cause shedding (OK, a lot of medicines have this listed as a possible side-effect).

It is not a new medicine and it has been taken orally for a long time , how come the beneficial effects for slowing down the shedding (not talking about regrowth) have not been reported?

97

quick update for this rather stagnant thread: i’m still using ramatroban + minox 2x daily. it’s been about 5 months since i started. previously i was using minox alone to very little effect. I have no shedding to speak of, and plenty of new vellus hairs in my temples. there’s some minor regrowth of terminal hairs in the temples, but i would not call it “cosmetically significant” - except for a 1 square cm spot along the left of my widows peak where a dying cowlick has come back to life. i’m 34, started noticeably balding at 21, and i think the last time i saw that cowlick was a few years ago. If i were to post pics they would look a lot like those from alecbaldone and darkcloud. i can’t complain too much, being that i’m not a fan of oral/systemic hormonal meds, and to find a topical capable of arresting hair loss is a step in the right direction. but i haven’t experienced much improvement since my last post 1-2 months ago. my terminal hairs are healthy and i dare say look pretty damn good.

no side effects. no other drugs involved.

i might snag a dermaroller. we’ll see. i’ll continue to post updates.

98

excellent news Boddha. As I suspected, you younger guys have a better chance of regrowth. I am 44 so my hairs have been dead for many years and I am only seeing new vellus hair.

99

yeah man. well i’ll keep updating and i wish you the best. it would be really nice to get some freakin decent regrowth for all of us. i’ve been through everything from finasteride, fluridil, and revivogen to dr. lee’s 5% spiro cream back in the day. this is the first time since the fin that i can say something is actually doing something reasonably good for me

100

[quote][postedby]Originally Posted by boddha[/postedby]
i might snag a dermaroller. we’ll see. i’ll continue to post updates.[/quote]

Instead of dermaroller, which will only help ensure the meds penetrate deeper into the scalp. Why not use some at-home microdermabrasion kit e.g. Neutrogena Microdermabrasion? They are painless, have no downtime, and will obviously trigger stems-cells to rejuvenate the scalp - so I’m hoping they have a better chance of turning those vellus hair into terminal hair. Keep in mind that’s exactly what Cotsarelis’ team have been doing as well…light wounding.

I’d try it out, but I’m NW7, so it’ll be really hard for me to identify results.