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#21

WO 2006087759 20060824

PHARMACEUTICAL COMPOSITION COMPRISING CURCUMIN AND RESVERATROL AND USES THEREOF IN MEDICAL FIELD

The present invention deals with a pharmaceutical composition comprising curcumin and resveratrol and uses thereof in medical field. More specifically, the composition object of the invention can be advantageously employed for retarding ageing, for the prevention of vascular diseases, for the treatment and prevention of cancers as, for example, prostate carcinoma, skin diseases as psoriasis, and diseases of the piliferous system as hair loss.

Resveratrol is a polyphenol present in grapes, especially in its peel and in its seeds, but also in a plant, the Polygonum Cuspidatum. Numbers of scientific researches have shown the in vitro efficacy of the Resveratrol in reducing the proliferation of human carcinogenic cells (Annals of the New York Academy of Science 957:210-229 (2002); Anticancer Res. 2004 Sept-Oct, 24(5A):2783-840; J Urol. 2002 Aug 168(2):748-55; Biochem Pharmacol 2004 Sep 15 68(6):1113-8; Drugs exp din Res 2003 29(5-6):257-61). Moreover, the regular use of red wine in France could explain the so-called “French Paradox”, that is the low incidence of coronary diseases in French population even if its diet has a high fat content.

The researches carried out by D. Sinclair and others, published on the magazine NATURE ((2789-9/7/2004-VBCKNELL-111861), aroused great interest by considering the opportunity of a life extension in good conditions. The researches are based on data dated many years ago that showed that a controlled diet prolonged life of the Drosophila Melanogaster, even if as side effect the animal manifested drowsiness. It has been shown that the admixture of resveratrol to diet gives the same results of a controlled diet, but eliminating any negative side effect.

Moreover Sinclair, who discovered the ability of Resveratrol of prolonging the life of yeasts, tried it on fruit-flies and small worms that have biological processes similar to the human ones. He ascertained an increased activity and fertility, together with a greater egg production. Curcumin is an extract of the root of the Curcumea Longa, a plant well known since a long time for its pharmaceutical properties. Nowadays curcumin is well known for its power of reducing cholesterol, its

diuretic, choleretic, anti-inflammatory ability and for ameliorating the general conditions of patients treated with chemotherapy for neoplasia.

Particular feature of Curcumin is to belong to the capsaicinoids family, substances characterized by a pungent taste, similar to the one of pepper. From a point of view of molecular biology, the presence of a vanilloid receptor on the cell membrane and close to the mitochondrial structures can explain the induction of apoptosis or planned death of cells that would have become neoplastic. Moreover, in the Central Nervous System there are various receptors of capsaicinoids and this could explain the enhancement of the anti-aging action of resveratrol by curcumin.

The authors of the present invention, starting from the recognized anti-inflammable and anti-neoplastic action of resveratrol and curcumin, have tested two mixtures with an antioxidant action. The first one is made of basically resveratrol (called Resverage) and the other one made of resveratrol and curcumin (called Capsures). The mixtures have been packaged in capsules for oral use. At the beginning the compounds have been administered to patients with prostate carcinoma insensible to hormones. The choice of these patients depends of the fact that the evolution of neoplasia can easily be monitored by the prostate-specific antigens (PSA).

The group of patients that has assumed only resveratrol didn’t show any modification on the PSA, while the group treated with resveratrol and curcumin showed with great surprise a reduction, sometimes also relevant, in variable time periods. Moreover, during this testing, the patients treated with resveratrol and curcumin surprisingly showed positive improvements in the treatment of psoriasis and the attenuation and even a stop of the hair loss, a reduction of the hair graying and the rebirth of hair in bald areas sometimes even of the original color too. This aspect polarized the attention and the mechanism that ruled the association of the two substances became the object of the studies. The physic and pathologic basis of the action of the association of resveratrol and curcumin can be found in the relationship existing between the congenital hyposensitization of the sensory fibers of rats and the skin lesions similar to psoriatic lesions. In that case, the administration of a substance that reactivates the skin tropism would open new ways to the treatment of skin lesions.1A possible theory is that it is possible to stimulate the peripheral •

sensory fibers with tropic function by associating curcumin and resveratrol. Regarding its action on hair growth, even if not yet known, it is probably linked to the release of P substance. The growth and the pigmentation of the hair follicle would depend on mesenchymal-epithelium-neiroderic interactions not very well-known yet, where the P substance would stimulate the hair growth in vivo (RaIf Paus et al Investigation Labs, VoI 71, No 1 , p.135, 1994).

Figure 1 shows a scheme of the capsaicin-sensible sensory neuron and the localization of tackykinins (P substance and Neurokinin A) and CGRP with the receptors TRPV 1. The scheme would show the double function, afferent and efferent, of the sensorial fibers with the release of neuropeptides from the terminal like the P substance, Neurokinin A and CGRP (Calcitonin gene related peptides). Researches are progressing about the use of high dosages of Curcumin for the treatment of colon cancer, but it seems like any effect on the hair growth has been shown; Effect that instead has been obtained thanks to the administration of curcumin together with resveratrol.

Therefore, the object of the present invention is a pharmaceutical composition comprising resveratrol and/or the root of polygonum cuspidatum, containing resveratrol, and curcumin and/or root of the curcuma longa, containing curcumin, as active principles, in association with one or more adjuvant and/or excipients pharmacologically acceptable. The root of powdered polygonum cuspidatum, a plant commonly used in the traditional Chinese and Japanese medicine as circulatory tonic, is particularly rich in resveratrol. Epidemiological and in vitro studies suggest that its use reduces the incidence of cardiovascular diseases and cancers. The powdered root of Curcuma longa, a plant diffused in the oriental medicine, is very rich in active elements as curcuminoids, the elements responsible for the characteristic yellow color and probably for the anti-inflammatory, antiviral and detoxicant effects too.

According to the invention, the pharmaceutical composition can comprise also vitamin E and/or wheat germs containing vitamin E. In fact, the powdered wheat germs are one of the richest natural resources of vitamin E (or tocopherol) and are one of the most effective antioxidants against free radicals, the aggressive substances that proliferate in our body because of the action of pollution, inaccurate diets, sun or just age.

Moreover, according to the invention, the pharmaceutical composition can also comprise vitamin C and/or berries of Rosa canina containing vitamin C. In fact the powdered berry of Rosa canina is a natural source of C vitamin, important for the good functioning of the immune system and an excellent antioxidant too. The vitamin C fights any kind of infection and facilitates the repair of the connective tissue. The modern living conditions, the high level of air pollution, smoking and passive smoking, increase our need of vitamin C.

According to another embodiment of the present invention, the pharmaceutical composition can also comprise Capsaicin and/or the fruit of capsicum annum, which contains capsaicin. Capsicum annum, its powdered fruit in particular, is rich in important nutritional substances as flavonoids, vitamins (C, E, PP, and K), lecithins, mineral salts and capsaicin, an alkaloid responsible for its particular taste and for its activating properties. The extract of capsicum seems to be very effective in stimulating the vitality of the tissues and in activating the venous and capillary circulation.

In particular, in the composition according to this invention, the content of resveratrol can range from 3 to 6 mg; of Curcumin from 15 to 30 mg; of vitamin E from 50 to 100 mg; of vitamin C from 10 to 30 mg; of capsaicin from 2 to 5 mg; of powdered wheat germs from 50 to 450 mg,

• preferably from 100 to 350 mg; of powdered berries of Rosa canina from

50 to 450 mg, preferably from 100 to 350 mg; of the powdered fruit of capsicum annum from 50 to 450, preferably from 100 to 350 mg; of the powdered root of curcuma longa from 1 to 100 mg, preferably from 50 to 100 mg; of the powdered root of polygonum cuspidatum from 1 to 100 mg, preferably from 50 to 100 mg.

The abovementioned quantities are the quantities contained in one dosage unit. According to a preferred embodiment of the invention, the composition comprises Rosa canina (titrated dried extract) 10%; natural vitamin C 150.00 mg.; synthetic vitamin C 15.00 mg; Curcuma (titrated dried extract) 95%; Curcumin 20.60 mg; synthetic Curcumin 20.00 mg; Poligonum cuspidatum (titrated dried extract) 98%; resveratrol 5.10 mg; synthetic resveratrol 5.00 mg.; wheat germ oil 60.00 mg.; Capsicum (titrated dried extract) 60% in capsaicin 5.00 mg.; synthetic capsaicin 3.00 mg.

T/IT2006/000093

5

The composition according to the invention can be presented in capsules, pills, solution and emulsion. If in capsules or pills, the suggested dosage is one or two units, before meals.

Further object of the present invention is the use of the composition for the cancer treatment, in particular the treatment of prostate carcinoma. Moreover, the composition according to the invention can be advantageously employed for the treatment of skin diseases, in particular of psoriasis, for the treatment and the prevention from ageing, for the treatment and the prophylaxis of diseases .of the piliferous system, in particular of alopecia.

Another object of the present invention is a combination comprising resveratrol and curcumin for the simultaneous, separate or sequential use in the treatment of cancer, as for example, the prostate carcinoma, in the treatment of skin diseases as psoriasis and for the prevention and the treatment of alopecia.

It is understood that the abovementioned examples are just an exemplification offered to illustrate the practical usages of the invention.

The invention in fact can vary in its dosages and in its components, adding other components similar to the one suggested, but without altering the conceptual basis of the invention.

The present invention will now be described by way of information, not restrictively, in its preferred ways of presentation, with a particular reference to the attached pictures, where:

Figure 1 shows a scheme of the capsaicinoids-sensible sensory neuron, and the localization of tackykinins (substance P and Neurokinin A) and CGRP with the receptor TRPV 1.

Example 1 : Study on the effect of resveratrol and the association of resveratrol and curcumin on the prostate-specific antigen (PSA) in patients affected by prostate carcinoma, on hair growth and on psoriasis.

A composition has been prepared. It contains RESVERATROL (poligonum cuspidatum) and other antioxidants and it is called “Resverage”. Its ingredients are: Rosa canina (titrated dried extract) 10%; natural vitamin C 200.00 mg; synthetic vitamin C 20.00 mg; wheat germ oil 60.00 mg; poligonum cuspidatum (titrated dried extract) 98%; resveratrol 8.20 mg; synthetic resveratrol 8.00 mg. The administration capsules of this composition to 5 patients did not give any positive result. Thus, another

composition containing resveratrol and curcumin (Curcuma longa) has been prepared and tested on a bigger group of patients. In detail the composition was composed of:

  • Rosa canina (titrated dried extract) 10%, natural vitamin C 150.00 mg., synthetic vitamin C 15.00;

  • Curcuma (titrated dried extract) 95%, Curcumin20.60; synthetic Curcumin 20.00 mg

  • Poligonum cuspidatum (titrated dried extract) 98%; resveratrol 5.10 mg.; Synthetic resveratrol 5.00 mg - Wheat germ oil 60.00 mg, capsicum (titrated dried extract)

60% in capsaicin 5.00 mg; synthetic capsaicin 3.00 mg.

Ingredients: dicalcic phosphate, fruits of rosa canina (titrated dried extract) maltodextrins 10%; natural vitamin C, wheat germ oil plv titrated 40%(triticum vulgaris, modified amylum, microcrystalline cellulose, Curcuma rhizome (titrated dried extract)Curcuma Longa L. maltodextrins 95%; Curcumin, anti-agglomerative, vegetal stearate magnesium; coating agents: hydroxyl-propyl-methyl cellulose, glycerol, titanium dioxide; Capsicum fruit (titrated dried extract) [capsicum frutescens, capsicum annum) 60% in capsaicin, Poligonum Cuspidatum root (dried extract) 98%, resveratrol.

In this testing, apart from a relevant anti-cancer action on hormone-insensible prostate neoplasia, an effect on some patients has also been the stop of the hair loss and the growth of hair, sometimes of the original color too. Therefore patients without any neoplastic disease, but affected by alopecia or hair loss, have been included to the testing. MATERIALS AND METHODS

The group treated only with resveratrol didn’t show any relevant variation, except from two cases that showed a slight decrease.

Group treated with resveratrol: 5 patient, aged between 64 and 76 years old, affected by a hormone-independent prostate carcinoma have been treated with Resverage, 4 pills a day, for a period that ranged from 30 and 90 days. The basic PSA varied from 25/220 mg/ml and it has been monitored for the 15 days following the treatment period. The patients tolerated the therapy without showing any nuisance. Table n°1 shows the results obtained with the treatment with Resverage.

It is demonstrated that hair has a sensory innervation defined capsaicin-sensitive, whose characteristic is that the C-amyelinated fibers have an afferent and efferent function (see scheme of picture n°1).

Those fibers, whose nerve cell is in the posterior roots, once stimulated release neuropeptides like the P substance, Neurokinin A and the Calcitonin Gene Related Peptide (CGRP). Experimental researches demonstrated that the desensibilization of those fibers leads to skin lesions localized in the cervical region of the rat. These experiments indicate the existence of a tropic function. It is probable that the loss of hair is a result of the deficit of neuropeptides released by the fibers that innervate the scalp.

Therefore it is possible that the administration of a substance that has as activity similar to capsaicin, as the Curcumin that metabolizes like an active curcumoid, can stimulate the sensorial fibers that have a tropic function, and that resveratrol has a vehicular function on the tissues. Therefore, the composition of the present invention is active on cases of hormone-insensible prostate carcinoma but in particular on hair, as our research has proven. The efficacy of the composition according to the present invention also depends on the great lyophilic properties of a capsaicinoid, curcumin on the anti-inflammatory effect of the two substances.

The interference of the hormonal action on hair loss is unquestionable, even if capsaicinoid-sensible sensory innervations are an ancestral phenomenon that does not depend on the hormonal mechanisms, but through a metabolic way different from the ordinary one. The growth and the pigmentation of the hair follicle seem to be controlled by epitelius-mesenchimoneuroechtodermmic interactions not very well known, but with an important role of the P substance on the hair growth in vivo.


#22

Thanks for all the information guys. It has been vey useful. I will look more into it. Really useful information from everybody.


#23

» Thanks for all the information guys. It has been vey useful. I will look
» more into it. Really useful information from everybody.

More references here:

  1. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1810449/

  2. http://www.nutritionandmetabolism.com/content/5/1/17

  3. http://www.wipo.int/pctdb/en/wo.jsp?wo=2006087759


#24

Nice try


#25

» Nice try

That which causes cancer may also directly contribute to and/or accelerate one’s hair loss. Didn’t you know that?

But here is the hair loss study, again. This time, study it slowly old man:

PHARMACEUTICAL COMPOSITION COMPRISING CURCUMIN AND RESVERATROL AND USES THEREOF IN MEDICAL FIELD

The present invention deals with a pharmaceutical composition comprising curcumin and resveratrol and uses thereof in medical field. More specifically, the composition object of the invention can be advantageously employed for retarding ageing, for the prevention of vascular diseases, for the treatment and prevention of cancers as, for example, prostate carcinoma, skin diseases as psoriasis, and diseases of the piliferous system as hair loss.

Resveratrol is a polyphenol present in grapes, especially in its peel and in its seeds, but also in a plant, the Polygonum Cuspidatum. Numbers of scientific researches have shown the in vitro efficacy of the Resveratrol in reducing the proliferation of human carcinogenic cells (Annals of the New York Academy of Science 957:210-229 (2002); Anticancer Res. 2004 Sept-Oct, 24(5A):2783-840; J Urol. 2002 Aug 168(2):748-55; Biochem Pharmacol 2004 Sep 15 68(6):1113-8; Drugs exp din Res 2003 29(5-6):257-61). Moreover, the regular use of red wine in France could explain the so-called “French Paradox”, that is the low incidence of coronary diseases in French population even if its diet has a high fat content.

The researches carried out by D. Sinclair and others, published on the magazine NATURE ((2789-9/7/2004-VBCKNELL-111861), aroused great interest by considering the opportunity of a life extension in good conditions. The researches are based on data dated many years ago that showed that a controlled diet prolonged life of the Drosophila Melanogaster, even if as side effect the animal manifested drowsiness. It has been shown that the admixture of resveratrol to diet gives the same results of a controlled diet, but eliminating any negative side effect.

Moreover Sinclair, who discovered the ability of Resveratrol of prolonging the life of yeasts, tried it on fruit-flies and small worms that have biological processes similar to the human ones. He ascertained an increased activity and fertility, together with a greater egg production. Curcumin is an extract of the root of the Curcumea Longa, a plant well known since a long time for its pharmaceutical properties. Nowadays curcumin is well known for its power of reducing cholesterol, its

diuretic, choleretic, anti-inflammatory ability and for ameliorating the general conditions of patients treated with chemotherapy for neoplasia.

Particular feature of Curcumin is to belong to the capsaicinoids family, substances characterized by a pungent taste, similar to the one of pepper. From a point of view of molecular biology, the presence of a vanilloid receptor on the cell membrane and close to the mitochondrial structures can explain the induction of apoptosis or planned death of cells that would have become neoplastic. Moreover, in the Central Nervous System there are various receptors of capsaicinoids and this could explain the enhancement of the anti-aging action of resveratrol by curcumin.

The authors of the present invention, starting from the recognized anti-inflammable and anti-neoplastic action of resveratrol and curcumin, have tested two mixtures with an antioxidant action. The first one is made of basically resveratrol (called Resverage) and the other one made of resveratrol and curcumin (called Capsures). The mixtures have been packaged in capsules for oral use. At the beginning the compounds have been administered to patients with prostate carcinoma insensible to hormones. The choice of these patients depends of the fact that the evolution of neoplasia can easily be monitored by the prostate-specific antigens (PSA).

The group of patients that has assumed only resveratrol didn’t show any modification on the PSA, while the group treated with resveratrol and curcumin showed with great surprise a reduction, sometimes also relevant, in variable time periods. Moreover, during this testing, the patients treated with resveratrol and curcumin surprisingly showed positive improvements in the treatment of psoriasis and the attenuation and even a stop of the hair loss, a reduction of the hair graying and the rebirth of hair in bald areas sometimes even of the original color too. This aspect polarized the attention and the mechanism that ruled the association of the two substances became the object of the studies. The physic and pathologic basis of the action of the association of resveratrol and curcumin can be found in the relationship existing between the congenital hyposensitization of the sensory fibers of rats and the skin lesions similar to psoriatic lesions. In that case, the administration of a substance that reactivates the skin tropism would open new ways to the treatment of skin lesions.1A possible theory is that it is possible to stimulate the peripheral •

sensory fibers with tropic function by associating curcumin and resveratrol. Regarding its action on hair growth, even if not yet known, it is probably linked to the release of P substance. The growth and the pigmentation of the hair follicle would depend on mesenchymal-epithelium-neiroderic interactions not very well-known yet, where the P substance would stimulate the hair growth in vivo (RaIf Paus et al Investigation Labs, VoI 71, No 1 , p.135, 1994).

Figure 1 shows a scheme of the capsaicin-sensible sensory neuron and the localization of tackykinins (P substance and Neurokinin A) and CGRP with the receptors TRPV 1. The scheme would show the double function, afferent and efferent, of the sensorial fibers with the release of neuropeptides from the terminal like the P substance, Neurokinin A and CGRP (Calcitonin gene related peptides). Researches are progressing about the use of high dosages of Curcumin for the treatment of colon cancer, but it seems like any effect on the hair growth has been shown; Effect that instead has been obtained thanks to the administration of curcumin together with resveratrol.

Therefore, the object of the present invention is a pharmaceutical composition comprising resveratrol and/or the root of polygonum cuspidatum, containing resveratrol, and curcumin and/or root of the curcuma longa, containing curcumin, as active principles, in association with one or more adjuvant and/or excipients pharmacologically acceptable. The root of powdered polygonum cuspidatum, a plant commonly used in the traditional Chinese and Japanese medicine as circulatory tonic, is particularly rich in resveratrol. Epidemiological and in vitro studies suggest that its use reduces the incidence of cardiovascular diseases and cancers. The powdered root of Curcuma longa, a plant diffused in the oriental medicine, is very rich in active elements as curcuminoids, the elements responsible for the characteristic yellow color and probably for the anti-inflammatory, antiviral and detoxicant effects too.

According to the invention, the pharmaceutical composition can comprise also vitamin E and/or wheat germs containing vitamin E. In fact, the powdered wheat germs are one of the richest natural resources of vitamin E (or tocopherol) and are one of the most effective antioxidants against free radicals, the aggressive substances that proliferate in our body because of the action of pollution, inaccurate diets, sun or just age.

Moreover, according to the invention, the pharmaceutical composition can also comprise vitamin C and/or berries of Rosa canina containing vitamin C. In fact the powdered berry of Rosa canina is a natural source of C vitamin, important for the good functioning of the immune system and an excellent antioxidant too. The vitamin C fights any kind of infection and facilitates the repair of the connective tissue. The modern living conditions, the high level of air pollution, smoking and passive smoking, increase our need of vitamin C.

According to another embodiment of the present invention, the pharmaceutical composition can also comprise Capsaicin and/or the fruit of capsicum annum, which contains capsaicin. Capsicum annum, its powdered fruit in particular, is rich in important nutritional substances as flavonoids, vitamins (C, E, PP, and K), lecithins, mineral salts and capsaicin, an alkaloid responsible for its particular taste and for its activating properties. The extract of capsicum seems to be very effective in stimulating the vitality of the tissues and in activating the venous and capillary circulation.

In particular, in the composition according to this invention, the content of resveratrol can range from 3 to 6 mg; of Curcumin from 15 to 30 mg; of vitamin E from 50 to 100 mg; of vitamin C from 10 to 30 mg; of capsaicin from 2 to 5 mg; of powdered wheat germs from 50 to 450 mg,

• preferably from 100 to 350 mg; of powdered berries of Rosa canina from

50 to 450 mg, preferably from 100 to 350 mg; of the powdered fruit of capsicum annum from 50 to 450, preferably from 100 to 350 mg; of the powdered root of curcuma longa from 1 to 100 mg, preferably from 50 to 100 mg; of the powdered root of polygonum cuspidatum from 1 to 100 mg, preferably from 50 to 100 mg.

The abovementioned quantities are the quantities contained in one dosage unit. According to a preferred embodiment of the invention, the composition comprises Rosa canina (titrated dried extract) 10%; natural vitamin C 150.00 mg.; synthetic vitamin C 15.00 mg; Curcuma (titrated dried extract) 95%; Curcumin 20.60 mg; synthetic Curcumin 20.00 mg; Poligonum cuspidatum (titrated dried extract) 98%; resveratrol 5.10 mg; synthetic resveratrol 5.00 mg.; wheat germ oil 60.00 mg.; Capsicum (titrated dried extract) 60% in capsaicin 5.00 mg.; synthetic capsaicin 3.00 mg.

T/IT2006/000093

5

The composition according to the invention can be presented in capsules, pills, solution and emulsion. If in capsules or pills, the suggested dosage is one or two units, before meals.

Further object of the present invention is the use of the composition for the cancer treatment, in particular the treatment of prostate carcinoma. Moreover, the composition according to the invention can be advantageously employed for the treatment of skin diseases, in particular of psoriasis, for the treatment and the prevention from ageing, for the treatment and the prophylaxis of diseases .of the piliferous system, in particular of alopecia.

Another object of the present invention is a combination comprising resveratrol and curcumin for the simultaneous, separate or sequential use in the treatment of cancer, as for example, the prostate carcinoma, in the treatment of skin diseases as psoriasis and for the prevention and the treatment of alopecia.

It is understood that the abovementioned examples are just an exemplification offered to illustrate the practical usages of the invention.

The invention in fact can vary in its dosages and in its components, adding other components similar to the one suggested, but without altering the conceptual basis of the invention.

The present invention will now be described by way of information, not restrictively, in its preferred ways of presentation, with a particular reference to the attached pictures, where:

Figure 1 shows a scheme of the capsaicinoids-sensible sensory neuron, and the localization of tackykinins (substance P and Neurokinin A) and CGRP with the receptor TRPV 1.

Example 1 : Study on the effect of resveratrol and the association of resveratrol and curcumin on the prostate-specific antigen (PSA) in patients affected by prostate carcinoma, on hair growth and on psoriasis.

A composition has been prepared. It contains RESVERATROL (poligonum cuspidatum) and other antioxidants and it is called “Resverage”. Its ingredients are: Rosa canina (titrated dried extract) 10%; natural vitamin C 200.00 mg; synthetic vitamin C 20.00 mg; wheat germ oil 60.00 mg; poligonum cuspidatum (titrated dried extract) 98%; resveratrol 8.20 mg; synthetic resveratrol 8.00 mg. The administration capsules of this composition to 5 patients did not give any positive result. Thus, another

composition containing resveratrol and curcumin (Curcuma longa) has been prepared and tested on a bigger group of patients. In detail the composition was composed of:

  • Rosa canina (titrated dried extract) 10%, natural vitamin C 150.00 mg., synthetic vitamin C 15.00;

  • Curcuma (titrated dried extract) 95%, Curcumin20.60; synthetic Curcumin 20.00 mg

  • Poligonum cuspidatum (titrated dried extract) 98%; resveratrol 5.10 mg.; Synthetic resveratrol 5.00 mg - Wheat germ oil 60.00 mg, capsicum (titrated dried extract)

60% in capsaicin 5.00 mg; synthetic capsaicin 3.00 mg.

Ingredients: dicalcic phosphate, fruits of rosa canina (titrated dried extract) maltodextrins 10%; natural vitamin C, wheat germ oil plv titrated 40%(triticum vulgaris, modified amylum, microcrystalline cellulose, Curcuma rhizome (titrated dried extract)Curcuma Longa L. maltodextrins 95%; Curcumin, anti-agglomerative, vegetal stearate magnesium; coating agents: hydroxyl-propyl-methyl cellulose, glycerol, titanium dioxide; Capsicum fruit (titrated dried extract) [capsicum frutescens, capsicum annum) 60% in capsaicin, Poligonum Cuspidatum root (dried extract) 98%, resveratrol.

In this testing, apart from a relevant anti-cancer action on hormone-insensible prostate neoplasia, an effect on some patients has also been the stop of the hair loss and the growth of hair, sometimes of the original color too. Therefore patients without any neoplastic disease, but affected by alopecia or hair loss, have been included to the testing. MATERIALS AND METHODS

The group treated only with resveratrol didn’t show any relevant variation, except from two cases that showed a slight decrease.

Group treated with resveratrol: 5 patient, aged between 64 and 76 years old, affected by a hormone-independent prostate carcinoma have been treated with Resverage, 4 pills a day, for a period that ranged from 30 and 90 days. The basic PSA varied from 25/220 mg/ml and it has been monitored for the 15 days following the treatment period. The patients tolerated the therapy without showing any nuisance. Table n°1 shows the results obtained with the treatment with Resverage.

It is demonstrated that hair has a sensory innervation defined capsaicin-sensitive, whose characteristic is that the C-amyelinated fibers have an afferent and efferent function (see scheme of picture n°1).

Those fibers, whose nerve cell is in the posterior roots, once stimulated release neuropeptides like the P substance, Neurokinin A and the Calcitonin Gene Related Peptide (CGRP). Experimental researches demonstrated that the desensibilization of those fibers leads to skin lesions localized in the cervical region of the rat. These experiments indicate the existence of a tropic function. It is probable that the loss of hair is a result of the deficit of neuropeptides released by the fibers that innervate the scalp.

Therefore it is possible that the administration of a substance that has as activity similar to capsaicin, as the Curcumin that metabolizes like an active curcumoid, can stimulate the sensorial fibers that have a tropic function, and that resveratrol has a vehicular function on the tissues. Therefore, the composition of the present invention is active on cases of hormone-insensible prostate carcinoma but in particular on hair, as our research has proven. The efficacy of the composition according to the present invention also depends on the great lyophilic properties of a capsaicinoid, curcumin on the anti-inflammatory effect of the two substances.

The interference of the hormonal action on hair loss is unquestionable, even if capsaicinoid-sensible sensory innervations are an ancestral phenomenon that does not depend on the hormonal mechanisms, but through a metabolic way different from the ordinary one. The growth and the pigmentation of the hair follicle seem to be controlled by epitelius-mesenchimoneuroechtodermmic interactions not very well known, but with an important role of the P substance on the hair growth in vivo.


#26

Bunch of gibberish about Cancer prevention and curry powder and a few glancing mentions about hair loss

how about this
since your “study” so rarely mentions hair loss and we dont have the time or inclination to read all that crap

you go post the parts ABOUT HAIR LOSS in your “study”

also who did the study

its mostly a bunch of cancer prevention BS gobbledygook if you ask me


#27

That which causes cancer may also directly contribute to and/or accelerate one’s hair loss. Didn’t you know that?

But here is the hair loss study, again. This time, study it slowly old man:

PHARMACEUTICAL COMPOSITION COMPRISING CURCUMIN AND RESVERATROL AND USES THEREOF IN MEDICAL FIELD

The present invention deals with a pharmaceutical composition comprising curcumin and resveratrol and uses thereof in medical field. More specifically, the composition object of the invention can be advantageously employed for retarding ageing, for the prevention of vascular diseases, for the treatment and prevention of cancers as, for example, prostate carcinoma, skin diseases as psoriasis, and diseases of the piliferous system as hair loss.

Resveratrol is a polyphenol present in grapes, especially in its peel and in its seeds, but also in a plant, the Polygonum Cuspidatum. Numbers of scientific researches have shown the in vitro efficacy of the Resveratrol in reducing the proliferation of human carcinogenic cells (Annals of the New York Academy of Science 957:210-229 (2002); Anticancer Res. 2004 Sept-Oct, 24(5A):2783-840; J Urol. 2002 Aug 168(2):748-55; Biochem Pharmacol 2004 Sep 15 68(6):1113-8; Drugs exp din Res 2003 29(5-6):257-61). Moreover, the regular use of red wine in France could explain the so-called “French Paradox”, that is the low incidence of coronary diseases in French population even if its diet has a high fat content.

The researches carried out by D. Sinclair and others, published on the magazine NATURE ((2789-9/7/2004-VBCKNELL-111861), aroused great interest by considering the opportunity of a life extension in good conditions. The researches are based on data dated many years ago that showed that a controlled diet prolonged life of the Drosophila Melanogaster, even if as side effect the animal manifested drowsiness. It has been shown that the admixture of resveratrol to diet gives the same results of a controlled diet, but eliminating any negative side effect.

Moreover Sinclair, who discovered the ability of Resveratrol of prolonging the life of yeasts, tried it on fruit-flies and small worms that have biological processes similar to the human ones. He ascertained an increased activity and fertility, together with a greater egg production. Curcumin is an extract of the root of the Curcumea Longa, a plant well known since a long time for its pharmaceutical properties. Nowadays curcumin is well known for its power of reducing cholesterol, its

diuretic, choleretic, anti-inflammatory ability and for ameliorating the general conditions of patients treated with chemotherapy for neoplasia.

Particular feature of Curcumin is to belong to the capsaicinoids family, substances characterized by a pungent taste, similar to the one of pepper. From a point of view of molecular biology, the presence of a vanilloid receptor on the cell membrane and close to the mitochondrial structures can explain the induction of apoptosis or planned death of cells that would have become neoplastic. Moreover, in the Central Nervous System there are various receptors of capsaicinoids and this could explain the enhancement of the anti-aging action of resveratrol by curcumin.

The authors of the present invention, starting from the recognized anti-inflammable and anti-neoplastic action of resveratrol and curcumin, have tested two mixtures with an antioxidant action. The first one is made of basically resveratrol (called Resverage) and the other one made of resveratrol and curcumin (called Capsures). The mixtures have been packaged in capsules for oral use. At the beginning the compounds have been administered to patients with prostate carcinoma insensible to hormones. The choice of these patients depends of the fact that the evolution of neoplasia can easily be monitored by the prostate-specific antigens (PSA).

The group of patients that has assumed only resveratrol didn’t show any modification on the PSA, while the group treated with resveratrol and curcumin showed with great surprise a reduction, sometimes also relevant, in variable time periods. Moreover, during this testing, the patients treated with resveratrol and curcumin surprisingly showed positive improvements in the treatment of psoriasis and the attenuation and even a stop of the hair loss, a reduction of the hair graying and the rebirth of hair in bald areas sometimes even of the original color too. This aspect polarized the attention and the mechanism that ruled the association of the two substances became the object of the studies. The physic and pathologic basis of the action of the association of resveratrol and curcumin can be found in the relationship existing between the congenital hyposensitization of the sensory fibers of rats and the skin lesions similar to psoriatic lesions. In that case, the administration of a substance that reactivates the skin tropism would open new ways to the treatment of skin lesions.1A possible theory is that it is possible to stimulate the peripheral ・

sensory fibers with tropic function by associating curcumin and resveratrol. Regarding its action on hair growth, even if not yet known, it is probably linked to the release of P substance. The growth and the pigmentation of the hair follicle would depend on mesenchymal-epithelium-neiroderic interactions not very well-known yet, where the P substance would stimulate the hair growth in vivo (RaIf Paus et al Investigation Labs, VoI 71, No 1 , p.135, 1994).

Figure 1 shows a scheme of the capsaicin-sensible sensory neuron and the localization of tackykinins (P substance and Neurokinin A) and CGRP with the receptors TRPV 1. The scheme would show the double function, afferent and efferent, of the sensorial fibers with the release of neuropeptides from the terminal like the P substance, Neurokinin A and CGRP (Calcitonin gene related peptides). Researches are progressing about the use of high dosages of Curcumin for the treatment of colon cancer, but it seems like any effect on the hair growth has been shown; Effect that instead has been obtained thanks to the administration of curcumin together with resveratrol.

Therefore, the object of the present invention is a pharmaceutical composition comprising resveratrol and/or the root of polygonum cuspidatum, containing resveratrol, and curcumin and/or root of the curcuma longa, containing curcumin, as active principles, in association with one or more adjuvant and/or excipients pharmacologically acceptable. The root of powdered polygonum cuspidatum, a plant commonly used in the traditional Chinese and Japanese medicine as circulatory tonic, is particularly rich in resveratrol. Epidemiological and in vitro studies suggest that its use reduces the incidence of cardiovascular diseases and cancers. The powdered root of Curcuma longa, a plant diffused in the oriental medicine, is very rich in active elements as curcuminoids, the elements responsible for the characteristic yellow color and probably for the anti-inflammatory, antiviral and detoxicant effects too.

According to the invention, the pharmaceutical composition can comprise also vitamin E and/or wheat germs containing vitamin E. In fact, the powdered wheat germs are one of the richest natural resources of vitamin E (or tocopherol) and are one of the most effective antioxidants against free radicals, the aggressive substances that proliferate in our body because of the action of pollution, inaccurate diets, sun or just age.

Moreover, according to the invention, the pharmaceutical composition can also comprise vitamin C and/or berries of Rosa canina containing vitamin C. In fact the powdered berry of Rosa canina is a natural source of C vitamin, important for the good functioning of the immune system and an excellent antioxidant too. The vitamin C fights any kind of infection and facilitates the repair of the connective tissue. The modern living conditions, the high level of air pollution, smoking and passive smoking, increase our need of vitamin C.

According to another embodiment of the present invention, the pharmaceutical composition can also comprise Capsaicin and/or the fruit of capsicum annum, which contains capsaicin. Capsicum annum, its powdered fruit in particular, is rich in important nutritional substances as flavonoids, vitamins (C, E, PP, and K), lecithins, mineral salts and capsaicin, an alkaloid responsible for its particular taste and for its activating properties. The extract of capsicum seems to be very effective in stimulating the vitality of the tissues and in activating the venous and capillary circulation.

In particular, in the composition according to this invention, the content of resveratrol can range from 3 to 6 mg; of Curcumin from 15 to 30 mg; of vitamin E from 50 to 100 mg; of vitamin C from 10 to 30 mg; of capsaicin from 2 to 5 mg; of powdered wheat germs from 50 to 450 mg,

・preferably from 100 to 350 mg; of powdered berries of Rosa canina from

50 to 450 mg, preferably from 100 to 350 mg; of the powdered fruit of capsicum annum from 50 to 450, preferably from 100 to 350 mg; of the powdered root of curcuma longa from 1 to 100 mg, preferably from 50 to 100 mg; of the powdered root of polygonum cuspidatum from 1 to 100 mg, preferably from 50 to 100 mg.

The abovementioned quantities are the quantities contained in one dosage unit. According to a preferred embodiment of the invention, the composition comprises Rosa canina (titrated dried extract) 10%; natural vitamin C 150.00 mg.; synthetic vitamin C 15.00 mg; Curcuma (titrated dried extract) 95%; Curcumin 20.60 mg; synthetic Curcumin 20.00 mg; Poligonum cuspidatum (titrated dried extract) 98%; resveratrol 5.10 mg; synthetic resveratrol 5.00 mg.; wheat germ oil 60.00 mg.; Capsicum (titrated dried extract) 60% in capsaicin 5.00 mg.; synthetic capsaicin 3.00 mg.

T/IT2006/000093

5

The composition according to the invention can be presented in capsules, pills, solution and emulsion. If in capsules or pills, the suggested dosage is one or two units, before meals.

Further object of the present invention is the use of the composition for the cancer treatment, in particular the treatment of prostate carcinoma. Moreover, the composition according to the invention can be advantageously employed for the treatment of skin diseases, in particular of psoriasis, for the treatment and the prevention from ageing, for the treatment and the prophylaxis of diseases .of the piliferous system, in particular of alopecia.

Another object of the present invention is a combination comprising resveratrol and curcumin for the simultaneous, separate or sequential use in the treatment of cancer, as for example, the prostate carcinoma, in the treatment of skin diseases as psoriasis and for the prevention and the treatment of alopecia.

It is understood that the abovementioned examples are just an exemplification offered to illustrate the practical usages of the invention.

The invention in fact can vary in its dosages and in its components, adding other components similar to the one suggested, but without altering the conceptual basis of the invention.

The present invention will now be described by way of information, not restrictively, in its preferred ways of presentation, with a particular reference to the attached pictures, where:

Figure 1 shows a scheme of the capsaicinoids-sensible sensory neuron, and the localization of tackykinins (substance P and Neurokinin A) and CGRP with the receptor TRPV 1.

Example 1 : Study on the effect of resveratrol and the association of resveratrol and curcumin on the prostate-specific antigen (PSA) in patients affected by prostate carcinoma, on hair growth and on psoriasis.

A composition has been prepared. It contains RESVERATROL (poligonum cuspidatum) and other antioxidants and it is called “Resverage”. Its ingredients are: Rosa canina (titrated dried extract) 10%; natural vitamin C 200.00 mg; synthetic vitamin C 20.00 mg; wheat germ oil 60.00 mg; poligonum cuspidatum (titrated dried extract) 98%; resveratrol 8.20 mg; synthetic resveratrol 8.00 mg. The administration capsules of this composition to 5 patients did not give any positive result. Thus, another

composition containing resveratrol and curcumin (Curcuma longa) has been prepared and tested on a bigger group of patients. In detail the composition was composed of:

  • Rosa canina (titrated dried extract) 10%, natural vitamin C 150.00 mg., synthetic vitamin C 15.00;

  • Curcuma (titrated dried extract) 95%, Curcumin20.60; synthetic Curcumin 20.00 mg

  • Poligonum cuspidatum (titrated dried extract) 98%; resveratrol 5.10 mg.; Synthetic resveratrol 5.00 mg - Wheat germ oil 60.00 mg, capsicum (titrated dried extract)

60% in capsaicin 5.00 mg; synthetic capsaicin 3.00 mg.

Ingredients: dicalcic phosphate, fruits of rosa canina (titrated dried extract) maltodextrins 10%; natural vitamin C, wheat germ oil plv titrated 40%(triticum vulgaris, modified amylum, microcrystalline cellulose, Curcuma rhizome (titrated dried extract)Curcuma Longa L. maltodextrins 95%; Curcumin, anti-agglomerative, vegetal stearate magnesium; coating agents: hydroxyl-propyl-methyl cellulose, glycerol, titanium dioxide; Capsicum fruit (titrated dried extract) [capsicum frutescens, capsicum annum) 60% in capsaicin, Poligonum Cuspidatum root (dried extract) 98%, resveratrol.

In this testing, apart from a relevant anti-cancer action on hormone-insensible prostate neoplasia, an effect on some patients has also been the stop of the hair loss and the growth of hair, sometimes of the original color too. Therefore patients without any neoplastic disease, but affected by alopecia or hair loss, have been included to the testing. MATERIALS AND METHODS

The group treated only with resveratrol didn’t show any relevant variation, except from two cases that showed a slight decrease.

Group treated with resveratrol: 5 patient, aged between 64 and 76 years old, affected by a hormone-independent prostate carcinoma have been treated with Resverage, 4 pills a day, for a period that ranged from 30 and 90 days. The basic PSA varied from 25/220 mg/ml and it has been monitored for the 15 days following the treatment period. The patients tolerated the therapy without showing any nuisance. Table nー1 shows the results obtained with the treatment with Resverage.

It is demonstrated that hair has a sensory innervation defined capsaicin-sensitive, whose characteristic is that the C-amyelinated fibers have an afferent and efferent function (see scheme of picture nー1).

Those fibers, whose nerve cell is in the posterior roots, once stimulated release neuropeptides like the P substance, Neurokinin A and the Calcitonin Gene Related Peptide (CGRP). Experimental researches demonstrated that the desensibilization of those fibers leads to skin lesions localized in the cervical region of the rat. These experiments indicate the existence of a tropic function. It is probable that the loss of hair is a result of the deficit of neuropeptides released by the fibers that innervate the scalp.

Therefore it is possible that the administration of a substance that has as activity similar to capsaicin, as the Curcumin that metabolizes like an active curcumoid, can stimulate the sensorial fibers that have a tropic function, and that resveratrol has a vehicular function on the tissues. Therefore, the composition of the present invention is active on cases of hormone-insensible prostate carcinoma but in particular on hair, as our research has proven. The efficacy of the composition according to the present invention also depends on the great lyophilic properties of a capsaicinoid, curcumin on the anti-inflammatory effect of the two substances.

The interference of the hormonal action on hair loss is unquestionable, even if capsaicinoid-sensible sensory innervations are an ancestral phenomenon that does not depend on the hormonal mechanisms, but through a metabolic way different from the ordinary one. The growth and the pigmentation of the hair follicle seem to be controlled by epitelius-mesenchimoneuroechtodermmic interactions not very well known, but with an important role of the P substance on the hair growth in vivo.


#28

That which causes cancer may also directly contribute to and/or accelerate one’s hair loss. Didn’t you know that?

So, therefore you are implying that since your study , supposedly proves that curry powder is helpful in cancer prevention (unproven)
that it also helps with hair loss? ummmmmmmmmmmmm

So basically

  1. the study you posted DID NOT SAY that curcumin and resveratrol stop hair loss, the study was about cancer:stuck_out_tongue: :stuck_out_tongue:

  2. it made a glancing mention of hair loss (the study was not about hair loss)

  3. so you had to INFER that since YOU THINK that cancer prevention is related to hair loss prevention, that MUST MEAN that the lame study you posted supports your theory that curcumin and Resveratrol prevent hair loss.

Thats also very sad and pathetic .:stuck_out_tongue: :stuck_out_tongue: :smiley: :smiley: …you having to twist the study results to say something that the study clearly did not say…

course when push comes to shove and there are no studies to back up your claims, what other choice did you have? other than to make up Sh.it?

retardedEINSTEIN :stuck_out_tongue: :stuck_out_tongue: :stuck_out_tongue: :stuck_out_tongue: :stuck_out_tongue: :stuck_out_tongue:


#29

That which causes cancer may also directly contribute to and/or accelerate one’s hair loss. Didn’t you know that?

But here is the hair loss study, again. This time, study it slowly old man:

PHARMACEUTICAL COMPOSITION COMPRISING CURCUMIN AND RESVERATROL AND USES THEREOF IN MEDICAL FIELD

The present invention deals with a pharmaceutical composition comprising curcumin and resveratrol and uses thereof in medical field. More specifically, the composition object of the invention can be advantageously employed for retarding ageing, for the prevention of vascular diseases, for the treatment and prevention of cancers as, for example, prostate carcinoma, skin diseases as psoriasis, and diseases of the piliferous system as hair loss.

Resveratrol is a polyphenol present in grapes, especially in its peel and in its seeds, but also in a plant, the Polygonum Cuspidatum. Numbers of scientific researches have shown the in vitro efficacy of the Resveratrol in reducing the proliferation of human carcinogenic cells (Annals of the New York Academy of Science 957:210-229 (2002); Anticancer Res. 2004 Sept-Oct, 24(5A):2783-840; J Urol. 2002 Aug 168(2):748-55; Biochem Pharmacol 2004 Sep 15 68(6):1113-8; Drugs exp din Res 2003 29(5-6):257-61). Moreover, the regular use of red wine in France could explain the so-called “French Paradox”, that is the low incidence of coronary diseases in French population even if its diet has a high fat content.

The researches carried out by D. Sinclair and others, published on the magazine NATURE ((2789-9/7/2004-VBCKNELL-111861), aroused great interest by considering the opportunity of a life extension in good conditions. The researches are based on data dated many years ago that showed that a controlled diet prolonged life of the Drosophila Melanogaster, even if as side effect the animal manifested drowsiness. It has been shown that the admixture of resveratrol to diet gives the same results of a controlled diet, but eliminating any negative side effect.

Moreover Sinclair, who discovered the ability of Resveratrol of prolonging the life of yeasts, tried it on fruit-flies and small worms that have biological processes similar to the human ones. He ascertained an increased activity and fertility, together with a greater egg production. Curcumin is an extract of the root of the Curcumea Longa, a plant well known since a long time for its pharmaceutical properties. Nowadays curcumin is well known for its power of reducing cholesterol, its

diuretic, choleretic, anti-inflammatory ability and for ameliorating the general conditions of patients treated with chemotherapy for neoplasia.

Particular feature of Curcumin is to belong to the capsaicinoids family, substances characterized by a pungent taste, similar to the one of pepper. From a point of view of molecular biology, the presence of a vanilloid receptor on the cell membrane and close to the mitochondrial structures can explain the induction of apoptosis or planned death of cells that would have become neoplastic. Moreover, in the Central Nervous System there are various receptors of capsaicinoids and this could explain the enhancement of the anti-aging action of resveratrol by curcumin.

The authors of the present invention, starting from the recognized anti-inflammable and anti-neoplastic action of resveratrol and curcumin, have tested two mixtures with an antioxidant action. The first one is made of basically resveratrol (called Resverage) and the other one made of resveratrol and curcumin (called Capsures). The mixtures have been packaged in capsules for oral use. At the beginning the compounds have been administered to patients with prostate carcinoma insensible to hormones. The choice of these patients depends of the fact that the evolution of neoplasia can easily be monitored by the prostate-specific antigens (PSA).

The group of patients that has assumed only resveratrol didn’t show any modification on the PSA, while the group treated with resveratrol and curcumin showed with great surprise a reduction, sometimes also relevant, in variable time periods. Moreover, during this testing, the patients treated with resveratrol and curcumin surprisingly showed positive improvements in the treatment of psoriasis and the attenuation and even a stop of the hair loss, a reduction of the hair graying and the rebirth of hair in bald areas sometimes even of the original color too. This aspect polarized the attention and the mechanism that ruled the association of the two substances became the object of the studies. The physic and pathologic basis of the action of the association of resveratrol and curcumin can be found in the relationship existing between the congenital hyposensitization of the sensory fibers of rats and the skin lesions similar to psoriatic lesions. In that case, the administration of a substance that reactivates the skin tropism would open new ways to the treatment of skin lesions.1A possible theory is that it is possible to stimulate the peripheral ・

sensory fibers with tropic function by associating curcumin and resveratrol. Regarding its action on hair growth, even if not yet known, it is probably linked to the release of P substance. The growth and the pigmentation of the hair follicle would depend on mesenchymal-epithelium-neiroderic interactions not very well-known yet, where the P substance would stimulate the hair growth in vivo (RaIf Paus et al Investigation Labs, VoI 71, No 1 , p.135, 1994).

Figure 1 shows a scheme of the capsaicin-sensible sensory neuron and the localization of tackykinins (P substance and Neurokinin A) and CGRP with the receptors TRPV 1. The scheme would show the double function, afferent and efferent, of the sensorial fibers with the release of neuropeptides from the terminal like the P substance, Neurokinin A and CGRP (Calcitonin gene related peptides). Researches are progressing about the use of high dosages of Curcumin for the treatment of colon cancer, but it seems like any effect on the hair growth has been shown; Effect that instead has been obtained thanks to the administration of curcumin together with resveratrol.

Therefore, the object of the present invention is a pharmaceutical composition comprising resveratrol and/or the root of polygonum cuspidatum, containing resveratrol, and curcumin and/or root of the curcuma longa, containing curcumin, as active principles, in association with one or more adjuvant and/or excipients pharmacologically acceptable. The root of powdered polygonum cuspidatum, a plant commonly used in the traditional Chinese and Japanese medicine as circulatory tonic, is particularly rich in resveratrol. Epidemiological and in vitro studies suggest that its use reduces the incidence of cardiovascular diseases and cancers. The powdered root of Curcuma longa, a plant diffused in the oriental medicine, is very rich in active elements as curcuminoids, the elements responsible for the characteristic yellow color and probably for the anti-inflammatory, antiviral and detoxicant effects too.

According to the invention, the pharmaceutical composition can comprise also vitamin E and/or wheat germs containing vitamin E. In fact, the powdered wheat germs are one of the richest natural resources of vitamin E (or tocopherol) and are one of the most effective antioxidants against free radicals, the aggressive substances that proliferate in our body because of the action of pollution, inaccurate diets, sun or just age.

Moreover, according to the invention, the pharmaceutical composition can also comprise vitamin C and/or berries of Rosa canina containing vitamin C. In fact the powdered berry of Rosa canina is a natural source of C vitamin, important for the good functioning of the immune system and an excellent antioxidant too. The vitamin C fights any kind of infection and facilitates the repair of the connective tissue. The modern living conditions, the high level of air pollution, smoking and passive smoking, increase our need of vitamin C.

According to another embodiment of the present invention, the pharmaceutical composition can also comprise Capsaicin and/or the fruit of capsicum annum, which contains capsaicin. Capsicum annum, its powdered fruit in particular, is rich in important nutritional substances as flavonoids, vitamins (C, E, PP, and K), lecithins, mineral salts and capsaicin, an alkaloid responsible for its particular taste and for its activating properties. The extract of capsicum seems to be very effective in stimulating the vitality of the tissues and in activating the venous and capillary circulation.

In particular, in the composition according to this invention, the content of resveratrol can range from 3 to 6 mg; of Curcumin from 15 to 30 mg; of vitamin E from 50 to 100 mg; of vitamin C from 10 to 30 mg; of capsaicin from 2 to 5 mg; of powdered wheat germs from 50 to 450 mg,

・preferably from 100 to 350 mg; of powdered berries of Rosa canina from

50 to 450 mg, preferably from 100 to 350 mg; of the powdered fruit of capsicum annum from 50 to 450, preferably from 100 to 350 mg; of the powdered root of curcuma longa from 1 to 100 mg, preferably from 50 to 100 mg; of the powdered root of polygonum cuspidatum from 1 to 100 mg, preferably from 50 to 100 mg.

The abovementioned quantities are the quantities contained in one dosage unit. According to a preferred embodiment of the invention, the composition comprises Rosa canina (titrated dried extract) 10%; natural vitamin C 150.00 mg.; synthetic vitamin C 15.00 mg; Curcuma (titrated dried extract) 95%; Curcumin 20.60 mg; synthetic Curcumin 20.00 mg; Poligonum cuspidatum (titrated dried extract) 98%; resveratrol 5.10 mg; synthetic resveratrol 5.00 mg.; wheat germ oil 60.00 mg.; Capsicum (titrated dried extract) 60% in capsaicin 5.00 mg.; synthetic capsaicin 3.00 mg.

T/IT2006/000093

5

The composition according to the invention can be presented in capsules, pills, solution and emulsion. If in capsules or pills, the suggested dosage is one or two units, before meals.

Further object of the present invention is the use of the composition for the cancer treatment, in particular the treatment of prostate carcinoma. Moreover, the composition according to the invention can be advantageously employed for the treatment of skin diseases, in particular of psoriasis, for the treatment and the prevention from ageing, for the treatment and the prophylaxis of diseases .of the piliferous system, in particular of alopecia.

Another object of the present invention is a combination comprising resveratrol and curcumin for the simultaneous, separate or sequential use in the treatment of cancer, as for example, the prostate carcinoma, in the treatment of skin diseases as psoriasis and for the prevention and the treatment of alopecia.

It is understood that the abovementioned examples are just an exemplification offered to illustrate the practical usages of the invention.

The invention in fact can vary in its dosages and in its components, adding other components similar to the one suggested, but without altering the conceptual basis of the invention.

The present invention will now be described by way of information, not restrictively, in its preferred ways of presentation, with a particular reference to the attached pictures, where:

Figure 1 shows a scheme of the capsaicinoids-sensible sensory neuron, and the localization of tackykinins (substance P and Neurokinin A) and CGRP with the receptor TRPV 1.

Example 1 : Study on the effect of resveratrol and the association of resveratrol and curcumin on the prostate-specific antigen (PSA) in patients affected by prostate carcinoma, on hair growth and on psoriasis.

A composition has been prepared. It contains RESVERATROL (poligonum cuspidatum) and other antioxidants and it is called “Resverage”. Its ingredients are: Rosa canina (titrated dried extract) 10%; natural vitamin C 200.00 mg; synthetic vitamin C 20.00 mg; wheat germ oil 60.00 mg; poligonum cuspidatum (titrated dried extract) 98%; resveratrol 8.20 mg; synthetic resveratrol 8.00 mg. The administration capsules of this composition to 5 patients did not give any positive result. Thus, another

composition containing resveratrol and curcumin (Curcuma longa) has been prepared and tested on a bigger group of patients. In detail the composition was composed of:

  • Rosa canina (titrated dried extract) 10%, natural vitamin C 150.00 mg., synthetic vitamin C 15.00;

  • Curcuma (titrated dried extract) 95%, Curcumin20.60; synthetic Curcumin 20.00 mg

  • Poligonum cuspidatum (titrated dried extract) 98%; resveratrol 5.10 mg.; Synthetic resveratrol 5.00 mg - Wheat germ oil 60.00 mg, capsicum (titrated dried extract)

60% in capsaicin 5.00 mg; synthetic capsaicin 3.00 mg.

Ingredients: dicalcic phosphate, fruits of rosa canina (titrated dried extract) maltodextrins 10%; natural vitamin C, wheat germ oil plv titrated 40%(triticum vulgaris, modified amylum, microcrystalline cellulose, Curcuma rhizome (titrated dried extract)Curcuma Longa L. maltodextrins 95%; Curcumin, anti-agglomerative, vegetal stearate magnesium; coating agents: hydroxyl-propyl-methyl cellulose, glycerol, titanium dioxide; Capsicum fruit (titrated dried extract) [capsicum frutescens, capsicum annum) 60% in capsaicin, Poligonum Cuspidatum root (dried extract) 98%, resveratrol.

In this testing, apart from a relevant anti-cancer action on hormone-insensible prostate neoplasia, an effect on some patients has also been the stop of the hair loss and the growth of hair, sometimes of the original color too. Therefore patients without any neoplastic disease, but affected by alopecia or hair loss, have been included to the testing. MATERIALS AND METHODS

The group treated only with resveratrol didn’t show any relevant variation, except from two cases that showed a slight decrease.

Group treated with resveratrol: 5 patient, aged between 64 and 76 years old, affected by a hormone-independent prostate carcinoma have been treated with Resverage, 4 pills a day, for a period that ranged from 30 and 90 days. The basic PSA varied from 25/220 mg/ml and it has been monitored for the 15 days following the treatment period. The patients tolerated the therapy without showing any nuisance. Table nー1 shows the results obtained with the treatment with Resverage.

It is demonstrated that hair has a sensory innervation defined capsaicin-sensitive, whose characteristic is that the C-amyelinated fibers have an afferent and efferent function (see scheme of picture nー1).

Those fibers, whose nerve cell is in the posterior roots, once stimulated release neuropeptides like the P substance, Neurokinin A and the Calcitonin Gene Related Peptide (CGRP). Experimental researches demonstrated that the desensibilization of those fibers leads to skin lesions localized in the cervical region of the rat. These experiments indicate the existence of a tropic function. It is probable that the loss of hair is a result of the deficit of neuropeptides released by the fibers that innervate the scalp.

Therefore it is possible that the administration of a substance that has as activity similar to capsaicin, as the Curcumin that metabolizes like an active curcumoid, can stimulate the sensorial fibers that have a tropic function, and that resveratrol has a vehicular function on the tissues. Therefore, the composition of the present invention is active on cases of hormone-insensible prostate carcinoma but in particular on hair, as our research has proven. The efficacy of the composition according to the present invention also depends on the great lyophilic properties of a capsaicinoid, curcumin on the anti-inflammatory effect of the two substances.

The interference of the hormonal action on hair loss is unquestionable, even if capsaicinoid-sensible sensory innervations are an ancestral phenomenon that does not depend on the hormonal mechanisms, but through a metabolic way different from the ordinary one. The growth and the pigmentation of the hair follicle seem to be controlled by epitelius-mesenchimoneuroechtodermmic interactions not very well known, but with an important role of the P substance on the hair growth in vivo.


#30

“…while the group treated with resveratrol and curcumin showed with great surprise a reduction, sometimes also relevant, in variable time periods. Moreover, during this testing, the patients treated with resveratrol and curcumin surprisingly showed positive improvements in the treatment of psoriasis and the attenuation and even a stop of the hair loss, a reduction of the hair graying and the rebirth of hair in bald areas sometimes even of the original color too.”


#31

Ann Oncol. 2011 Feb 15.
Male pattern baldness and the risk of prostate cancer.
Yassa M, Saliou M, De Rycke Y, Hemery C, Henni M, Bachaud JM, Thiounn N, Cosset JM, Giraud P.

Department of Oncology Radiotherapy, European Georges Pompidou Hospital.

Background: Androgens play a role in the development of both androgenic alopecia, commonly known as male pattern baldness, and prostate cancer. We set out to study if early-onset androgenic alopecia was associated with an increased risk of prostate cancer later in life. Patients and methods: A total of 669 subjects (388 with a history of prostate cancer and 281 without) were enrolled in this study. All subjects were asked to score their balding pattern at ages 20, 30 and 40. Statistical comparison was subsequently done between both groups of patients. Results: Our study revealed that patients with prostate cancer were twice as likely to have androgenic alopecia at age 20 [odds ratio (OR) 2.01, P = 0.0285]. The pattern of hair loss was not a predictive factor for the development of cancer. There was no association between early-onset alopecia and an earlier diagnosis of prostate cancer or with the development of more aggressive tumors. Conclusions: This study shows an association between early-onset androgenic alopecia and the development of prostate cancer. Whether this population can benefit from routine prostate cancer screening or systematic use of 5-alpha reductase inhibitors as primary prevention remains to be determined.

Since we already know there is an association between MPB and insulin resistance, especially in early balding, I think it’s clear that the risk factor prostate cancer simply increases with this factor. Cancer in general increases with insulin resistance.

5-alpha reductase inhibition is not the answer for prostate cancer prevention, because a metabolite of DHT is anti-carcinogenic. Ameliorating insulin resistance will reduce prostate cancer risks.


#32

my brother got prostate cancer at 50 , his hair was not thinning at all

I knew another guy full head of hair 57 who got prostate cancer

I find it dubious to do a “study” on 1000 people and this study is indicative of billions of men all over the world

10,000 people maybe
but 1000? dont think so

I also find these "studies " to be very blind to contributing factors

What factors in their lives did these balding prostate cancer sufferers have that contributed to their risk of prostate cancer AND contributed to early balding?
THAT IS THE QUESTION THEY NEED TO ANSWER

Example lets say another study took these exact same 1000 men and said
Yes the prostate cancer sufferers , were twice as likely to begin balding at age 20

However we found that the early balding men, when isolated in the study
half the men also admitted they smoked 1-3 packs of cigarettes per day (3 x more likely )
lived basically on junk food and hated exercise

thats what I mean about taking into account contributing factors and looking at the entire picture, not just saying oh these early balding guys are more likely to get prostate cancer

unless they look only at the early balding men who got prostate cancer and rule out all other factors that they shared that may have increased their chances not only at balding but at getting prostate cancer, the study is meaningless at best


#33

"Since we already know there is an association between MPB and insulin resistance, especially in early balding, I think it’s clear that the risk factor prostate cancer simply increases with this factor. Cancer in general increases with insulin resistance.

5-alpha reductase inhibition is not the answer for prostate cancer prevention, because a metabolite of DHT is anti-carcinogenic. Ameliorating insulin resistance will reduce prostate cancer risks."

What posters here need to understand is that there is more to reducing hair loss and preventing cancer than just inhibiting DHT. We must look into treatments like chelation and reducing insulin resistance, as more effective long-term approaches to these diseases.


#34

Newsflash its not

it is a hair loss forum

The natural, when asked to prove his regimen works, points to a cancer study that used his regimen and says , well since carcinogens tend to cause hair loss also, that means effective cancer treatments must also be effective hair loss treatments.

uh huh :stuck_out_tongue: :stuck_out_tongue: :stuck_out_tongue: :smiley: :smiley:


#35

“…while the group treated with resveratrol and curcumin showed with great surprise a reduction, sometimes also relevant, in variable time periods. Moreover, during this testing, the patients treated with resveratrol and curcumin surprisingly showed positive improvements in the treatment of psoriasis and the attenuation and even a stop of the hair loss, a reduction of the hair graying and the rebirth of hair in bald areas sometimes even of the original color too.”

The results of a clinical study examining the effect curcumin and resveratrol have on male pattern baldness.


#36

Most people who post studies also post all the details (medical journals dates NAME OF THE STUDY, by whom etc etc)

The only references in google to what you just pasted are in relation to a PATENT on a product. The “study” you refer to was vaguely referenced in their patent application.

How much you want to bet that this “study” was in fact fabricated , and it was done by the people applying for the patent? Gee what a surprise that would be. How convenient

If it were an actual double blind peer reviewed scientific study published in an approved medical journal, why did they not list the specs on the study? (by whom, what journal, what date, etc?)

Unless you can post proof that this “study” is legitimate, You just ended up with more egg on your face …:stuck_out_tongue: :stuck_out_tongue:


#37

A synergism does exist between curcumin and resveratrol. When used together, they can be an effective treatment against a variety of conditions, including but not limited to psoriasis and hair loss.

PHARMACEUTICAL COMPOSITION COMPRISING CURCUMIN AND RESVERATROL AND USES THEREOF IN MEDICAL FIELD

The present invention deals with a pharmaceutical composition comprising curcumin and resveratrol and uses thereof in medical field. More specifically, the composition object of the invention can be advantageously employed for retarding ageing, for the prevention of vascular diseases, for the treatment and prevention of cancers as, for example, prostate carcinoma, skin diseases as psoriasis, and diseases of the piliferous system as hair loss.

Resveratrol is a polyphenol present in grapes, especially in its peel and in its seeds, but also in a plant, the Polygonum Cuspidatum. Numbers of scientific researches have shown the in vitro efficacy of the Resveratrol in reducing the proliferation of human carcinogenic cells (Annals of the New York Academy of Science 957:210-229 (2002); Anticancer Res. 2004 Sept-Oct, 24(5A):2783-840; J Urol. 2002 Aug 168(2):748-55; Biochem Pharmacol 2004 Sep 15 68(6):1113-8; Drugs exp din Res 2003 29(5-6):257-61). Moreover, the regular use of red wine in France could explain the so-called “French Paradox”, that is the low incidence of coronary diseases in French population even if its diet has a high fat content.

The researches carried out by D. Sinclair and others, published on the magazine NATURE ((2789-9/7/2004-VBCKNELL-111861), aroused great interest by considering the opportunity of a life extension in good conditions. The researches are based on data dated many years ago that showed that a controlled diet prolonged life of the Drosophila Melanogaster, even if as side effect the animal manifested drowsiness. It has been shown that the admixture of resveratrol to diet gives the same results of a controlled diet, but eliminating any negative side effect.

Moreover Sinclair, who discovered the ability of Resveratrol of prolonging the life of yeasts, tried it on fruit-flies and small worms that have biological processes similar to the human ones. He ascertained an increased activity and fertility, together with a greater egg production. Curcumin is an extract of the root of the Curcumea Longa, a plant well known since a long time for its pharmaceutical properties. Nowadays curcumin is well known for its power of reducing cholesterol, its

diuretic, choleretic, anti-inflammatory ability and for ameliorating the general conditions of patients treated with chemotherapy for neoplasia.

Particular feature of Curcumin is to belong to the capsaicinoids family, substances characterized by a pungent taste, similar to the one of pepper. From a point of view of molecular biology, the presence of a vanilloid receptor on the cell membrane and close to the mitochondrial structures can explain the induction of apoptosis or planned death of cells that would have become neoplastic. Moreover, in the Central Nervous System there are various receptors of capsaicinoids and this could explain the enhancement of the anti-aging action of resveratrol by curcumin.

The authors of the present invention, starting from the recognized anti-inflammable and anti-neoplastic action of resveratrol and curcumin, have tested two mixtures with an antioxidant action. The first one is made of basically resveratrol (called Resverage) and the other one made of resveratrol and curcumin (called Capsures). The mixtures have been packaged in capsules for oral use. At the beginning the compounds have been administered to patients with prostate carcinoma insensible to hormones. The choice of these patients depends of the fact that the evolution of neoplasia can easily be monitored by the prostate-specific antigens (PSA).

The group of patients that has assumed only resveratrol didn’t show any modification on the PSA, while the group treated with resveratrol and curcumin showed with great surprise a reduction, sometimes also relevant, in variable time periods. Moreover, during this testing, the patients treated with resveratrol and curcumin surprisingly showed positive improvements in the treatment of psoriasis and the attenuation and even a stop of the hair loss, a reduction of the hair graying and the rebirth of hair in bald areas sometimes even of the original color too. This aspect polarized the attention and the mechanism that ruled the association of the two substances became the object of the studies. The physic and pathologic basis of the action of the association of resveratrol and curcumin can be found in the relationship existing between the congenital hyposensitization of the sensory fibers of rats and the skin lesions similar to psoriatic lesions. In that case, the administration of a substance that reactivates the skin tropism would open new ways to the treatment of skin lesions.1A possible theory is that it is possible to stimulate the peripheral ・

sensory fibers with tropic function by associating curcumin and resveratrol. Regarding its action on hair growth, even if not yet known, it is probably linked to the release of P substance. The growth and the pigmentation of the hair follicle would depend on mesenchymal-epithelium-neiroderic interactions not very well-known yet, where the P substance would stimulate the hair growth in vivo (RaIf Paus et al Investigation Labs, VoI 71, No 1 , p.135, 1994).

Figure 1 shows a scheme of the capsaicin-sensible sensory neuron and the localization of tackykinins (P substance and Neurokinin A) and CGRP with the receptors TRPV 1. The scheme would show the double function, afferent and efferent, of the sensorial fibers with the release of neuropeptides from the terminal like the P substance, Neurokinin A and CGRP (Calcitonin gene related peptides). Researches are progressing about the use of high dosages of Curcumin for the treatment of colon cancer, but it seems like any effect on the hair growth has been shown; Effect that instead has been obtained thanks to the administration of curcumin together with resveratrol.

Therefore, the object of the present invention is a pharmaceutical composition comprising resveratrol and/or the root of polygonum cuspidatum, containing resveratrol, and curcumin and/or root of the curcuma longa, containing curcumin, as active principles, in association with one or more adjuvant and/or excipients pharmacologically acceptable. The root of powdered polygonum cuspidatum, a plant commonly used in the traditional Chinese and Japanese medicine as circulatory tonic, is particularly rich in resveratrol. Epidemiological and in vitro studies suggest that its use reduces the incidence of cardiovascular diseases and cancers. The powdered root of Curcuma longa, a plant diffused in the oriental medicine, is very rich in active elements as curcuminoids, the elements responsible for the characteristic yellow color and probably for the anti-inflammatory, antiviral and detoxicant effects too.

According to the invention, the pharmaceutical composition can comprise also vitamin E and/or wheat germs containing vitamin E. In fact, the powdered wheat germs are one of the richest natural resources of vitamin E (or tocopherol) and are one of the most effective antioxidants against free radicals, the aggressive substances that proliferate in our body because of the action of pollution, inaccurate diets, sun or just age.

Moreover, according to the invention, the pharmaceutical composition can also comprise vitamin C and/or berries of Rosa canina containing vitamin C. In fact the powdered berry of Rosa canina is a natural source of C vitamin, important for the good functioning of the immune system and an excellent antioxidant too. The vitamin C fights any kind of infection and facilitates the repair of the connective tissue. The modern living conditions, the high level of air pollution, smoking and passive smoking, increase our need of vitamin C.

According to another embodiment of the present invention, the pharmaceutical composition can also comprise Capsaicin and/or the fruit of capsicum annum, which contains capsaicin. Capsicum annum, its powdered fruit in particular, is rich in important nutritional substances as flavonoids, vitamins (C, E, PP, and K), lecithins, mineral salts and capsaicin, an alkaloid responsible for its particular taste and for its activating properties. The extract of capsicum seems to be very effective in stimulating the vitality of the tissues and in activating the venous and capillary circulation.

In particular, in the composition according to this invention, the content of resveratrol can range from 3 to 6 mg; of Curcumin from 15 to 30 mg; of vitamin E from 50 to 100 mg; of vitamin C from 10 to 30 mg; of capsaicin from 2 to 5 mg; of powdered wheat germs from 50 to 450 mg,

・preferably from 100 to 350 mg; of powdered berries of Rosa canina from

50 to 450 mg, preferably from 100 to 350 mg; of the powdered fruit of capsicum annum from 50 to 450, preferably from 100 to 350 mg; of the powdered root of curcuma longa from 1 to 100 mg, preferably from 50 to 100 mg; of the powdered root of polygonum cuspidatum from 1 to 100 mg, preferably from 50 to 100 mg.

The abovementioned quantities are the quantities contained in one dosage unit. According to a preferred embodiment of the invention, the composition comprises Rosa canina (titrated dried extract) 10%; natural vitamin C 150.00 mg.; synthetic vitamin C 15.00 mg; Curcuma (titrated dried extract) 95%; Curcumin 20.60 mg; synthetic Curcumin 20.00 mg; Poligonum cuspidatum (titrated dried extract) 98%; resveratrol 5.10 mg; synthetic resveratrol 5.00 mg.; wheat germ oil 60.00 mg.; Capsicum (titrated dried extract) 60% in capsaicin 5.00 mg.; synthetic capsaicin 3.00 mg.

T/IT2006/000093

5

The composition according to the invention can be presented in capsules, pills, solution and emulsion. If in capsules or pills, the suggested dosage is one or two units, before meals.

Further object of the present invention is the use of the composition for the cancer treatment, in particular the treatment of prostate carcinoma. Moreover, the composition according to the invention can be advantageously employed for the treatment of skin diseases, in particular of psoriasis, for the treatment and the prevention from ageing, for the treatment and the prophylaxis of diseases .of the piliferous system, in particular of alopecia.

Another object of the present invention is a combination comprising resveratrol and curcumin for the simultaneous, separate or sequential use in the treatment of cancer, as for example, the prostate carcinoma, in the treatment of skin diseases as psoriasis and for the prevention and the treatment of alopecia.

It is understood that the abovementioned examples are just an exemplification offered to illustrate the practical usages of the invention.

The invention in fact can vary in its dosages and in its components, adding other components similar to the one suggested, but without altering the conceptual basis of the invention.

The present invention will now be described by way of information, not restrictively, in its preferred ways of presentation, with a particular reference to the attached pictures, where:

Figure 1 shows a scheme of the capsaicinoids-sensible sensory neuron, and the localization of tackykinins (substance P and Neurokinin A) and CGRP with the receptor TRPV 1.

Example 1 : Study on the effect of resveratrol and the association of resveratrol and curcumin on the prostate-specific antigen (PSA) in patients affected by prostate carcinoma, on hair growth and on psoriasis.

A composition has been prepared. It contains RESVERATROL (poligonum cuspidatum) and other antioxidants and it is called “Resverage”. Its ingredients are: Rosa canina (titrated dried extract) 10%; natural vitamin C 200.00 mg; synthetic vitamin C 20.00 mg; wheat germ oil 60.00 mg; poligonum cuspidatum (titrated dried extract) 98%; resveratrol 8.20 mg; synthetic resveratrol 8.00 mg. The administration capsules of this composition to 5 patients did not give any positive result. Thus, another

composition containing resveratrol and curcumin (Curcuma longa) has been prepared and tested on a bigger group of patients. In detail the composition was composed of:

  • Rosa canina (titrated dried extract) 10%, natural vitamin C 150.00 mg., synthetic vitamin C 15.00;

  • Curcuma (titrated dried extract) 95%, Curcumin20.60; synthetic Curcumin 20.00 mg

  • Poligonum cuspidatum (titrated dried extract) 98%; resveratrol 5.10 mg.; Synthetic resveratrol 5.00 mg - Wheat germ oil 60.00 mg, capsicum (titrated dried extract)

60% in capsaicin 5.00 mg; synthetic capsaicin 3.00 mg.

Ingredients: dicalcic phosphate, fruits of rosa canina (titrated dried extract) maltodextrins 10%; natural vitamin C, wheat germ oil plv titrated 40%(triticum vulgaris, modified amylum, microcrystalline cellulose, Curcuma rhizome (titrated dried extract)Curcuma Longa L. maltodextrins 95%; Curcumin, anti-agglomerative, vegetal stearate magnesium; coating agents: hydroxyl-propyl-methyl cellulose, glycerol, titanium dioxide; Capsicum fruit (titrated dried extract) [capsicum frutescens, capsicum annum) 60% in capsaicin, Poligonum Cuspidatum root (dried extract) 98%, resveratrol.

In this testing, apart from a relevant anti-cancer action on hormone-insensible prostate neoplasia, an effect on some patients has also been the stop of the hair loss and the growth of hair, sometimes of the original color too. Therefore patients without any neoplastic disease, but affected by alopecia or hair loss, have been included to the testing. MATERIALS AND METHODS

The group treated only with resveratrol didn’t show any relevant variation, except from two cases that showed a slight decrease.

Group treated with resveratrol: 5 patient, aged between 64 and 76 years old, affected by a hormone-independent prostate carcinoma have been treated with Resverage, 4 pills a day, for a period that ranged from 30 and 90 days. The basic PSA varied from 25/220 mg/ml and it has been monitored for the 15 days following the treatment period. The patients tolerated the therapy without showing any nuisance. Table nー1 shows the results obtained with the treatment with Resverage.

It is demonstrated that hair has a sensory innervation defined capsaicin-sensitive, whose characteristic is that the C-amyelinated fibers have an afferent and efferent function (see scheme of picture nー1).

Those fibers, whose nerve cell is in the posterior roots, once stimulated release neuropeptides like the P substance, Neurokinin A and the Calcitonin Gene Related Peptide (CGRP). Experimental researches demonstrated that the desensibilization of those fibers leads to skin lesions localized in the cervical region of the rat. These experiments indicate the existence of a tropic function. It is probable that the loss of hair is a result of the deficit of neuropeptides released by the fibers that innervate the scalp.

Therefore it is possible that the administration of a substance that has as activity similar to capsaicin, as the Curcumin that metabolizes like an active curcumoid, can stimulate the sensorial fibers that have a tropic function, and that resveratrol has a vehicular function on the tissues. Therefore, the composition of the present invention is active on cases of hormone-insensible prostate carcinoma but in particular on hair, as our research has proven. The efficacy of the composition according to the present invention also depends on the great lyophilic properties of a capsaicinoid, curcumin on the anti-inflammatory effect of the two substances.

The interference of the hormonal action on hair loss is unquestionable, even if capsaicinoid-sensible sensory innervations are an ancestral phenomenon that does not depend on the hormonal mechanisms, but through a metabolic way different from the ordinary one. The growth and the pigmentation of the hair follicle seem to be controlled by epitelius-mesenchimoneuroechtodermmic interactions not very well known, but with an important role of the P substance on the hair growth in vivo.


#38

…» Group treated with resveratrol: 5 patient, aged between 64 and 76 years
an important role of the P substance on the hair growth in vivo.

not much more to say on that LOL

FIVE PATIENTS and you call this a study?

Needless to say this proves my point, this is not a “study”:stuck_out_tongue: :stuck_out_tongue: :stuck_out_tongue:


#39

“Group treated with curcumin e resveratrol 20 patients, some of them affected by prostate neoplasia and/or by hair loss, treated with curcumin and resveratrol for a period ranging from 30 days to 6 months…As far as the action on hair is concerned, it is unquestionably due to the administration of the two combined active elements, since in the compound with just resveratrol no result has been shown and in the many cases in India and in Europe where Curcumin has been employed, any effect on hair has never been reported. The most important aspect rarely highlighted is that curcuminoids are capsaicinoid substances.”

And some of these patients were in their 60s! So instead of fighting with me, why don’t you try curcumin and resveratrol. Your DHT blockers have done nothing but make you a very grumpy old man with a bald crown.

Time for Plan B, Huckleberry.


#40

The Natural I feel sorry for you. Its sad really, your brain cells seem to have washed down the sink with what is left of your hair.

I am you and the other board members in 20 yrs

the big difference Is I still have my hair 90 percent of it.
You and most of the other board members , in 20 yrs hair will be a distant memory for you

I sincerely hope you find SOMETHING that works for you. I know you are now clinging to curcumin and Resveratrol. I wish you luck

:stuck_out_tongue: :stuck_out_tongue:

You and Nick cage have a lot in common, apparently