[Effect of Salvia miltiorrhiza on autocrining growth factor by fibroblasts cultured in vitro][Article in Chinese]
Wang YM, Wei FK, Liu M.
Department of Pediatric Surgery, West China Hospital, Sichuan University, Chengdu Sichuan, P. R. China 610041.
OBJECTIVE: To investigate the mechanism of overhealing alleviation by salvia miltiorrhiza (SM) in wound healing. METHODS: Fibroblasts were cultured in vitro, and SM was applied with different concentrations (40, 80, 160 and 320 micrograms/ml) and time(the 1st, 2nd, 3rd, 4th and 5th days) to influence their autocrine. The levels of transforming growth factor-beta 1 (TGF-beta 1) and epidermal growth factor (EGF) were determined by ELIAS and radioimmunoassay respectively. RESULTS: The SM could inhibit autocrine of TGF-beta 1 by fibroblasts (P < 0.05). However, it did not affect autocrine of EGF (P > 0.05). CONCLUSION: The above results indicate that SM reduces overhealing by inhibiting the autocrine of TGF-beta 1 selectively.
PMID: 12508435 [PubMed - indexed for MEDLINE]
Its one of the “big four” essential oils that was used for hairloss for eons until the medical establishment came along and told us that “nothing works for baldness”. The four were cedarwood, rosemary, sage, and thyme. There are versions of this sold thesedays in thickening shampoos with menthol usually substitutiong for cedarwood (probably because of the more pleasant smell). I have a feeling this stuff probably worked to help someone keep what they had. I know peppermint is an effective anti-androgen for a fact. Ive seen that on my own beard hair. Sage is now in a few “hairloss” shampoos like American Crew Thickening and “Fuller, Thicker Hair Shampoo” along with menthol, rosemary, and thyme.