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Sage oil..............TGF-beta 1 inhibitor


#1

[Effect of Salvia miltiorrhiza on autocrining growth factor by fibroblasts cultured in vitro][Article in Chinese]

Wang YM, Wei FK, Liu M.
Department of Pediatric Surgery, West China Hospital, Sichuan University, Chengdu Sichuan, P. R. China 610041.

OBJECTIVE: To investigate the mechanism of overhealing alleviation by salvia miltiorrhiza (SM) in wound healing. METHODS: Fibroblasts were cultured in vitro, and SM was applied with different concentrations (40, 80, 160 and 320 micrograms/ml) and time(the 1st, 2nd, 3rd, 4th and 5th days) to influence their autocrine. The levels of transforming growth factor-beta 1 (TGF-beta 1) and epidermal growth factor (EGF) were determined by ELIAS and radioimmunoassay respectively. RESULTS: The SM could inhibit autocrine of TGF-beta 1 by fibroblasts (P < 0.05). However, it did not affect autocrine of EGF (P > 0.05). CONCLUSION: The above results indicate that SM reduces overhealing by inhibiting the autocrine of TGF-beta 1 selectively.

PMID: 12508435 [PubMed - indexed for MEDLINE]

Its one of the “big four” essential oils that was used for hairloss for eons until the medical establishment came along and told us that “nothing works for baldness”. The four were cedarwood, rosemary, sage, and thyme. There are versions of this sold thesedays in thickening shampoos with menthol usually substitutiong for cedarwood (probably because of the more pleasant smell). I have a feeling this stuff probably worked to help someone keep what they had. I know peppermint is an effective anti-androgen for a fact. Ive seen that on my own beard hair. Sage is now in a few “hairloss” shampoos like American Crew Thickening and “Fuller, Thicker Hair Shampoo” along with menthol, rosemary, and thyme.


#2

» [Effect of Salvia miltiorrhiza on autocrining growth factor by fibroblasts
» cultured in vitro][Article in Chinese]
»
»
» Wang YM, Wei FK, Liu M.
» Department of Pediatric Surgery, West China Hospital, Sichuan University,
» Chengdu Sichuan, P. R. China 610041.
»
» OBJECTIVE: To investigate the mechanism of overhealing alleviation by
» salvia miltiorrhiza (SM) in wound healing. METHODS: Fibroblasts were
» cultured in vitro, and SM was applied with different concentrations (40,
» 80, 160 and 320 micrograms/ml) and time(the 1st, 2nd, 3rd, 4th and 5th
» days) to influence their autocrine. The levels of transforming growth
» factor-beta 1 (TGF-beta 1) and epidermal growth factor (EGF) were
» determined by ELIAS and radioimmunoassay respectively. RESULTS: The SM
» could inhibit autocrine of TGF-beta 1 by fibroblasts (P < 0.05). However,
» it did not affect autocrine of EGF (P > 0.05). CONCLUSION: The above
» results indicate that SM reduces overhealing by inhibiting the autocrine
» of TGF-beta 1 selectively.
»
» PMID: 12508435 [PubMed - indexed for MEDLINE]
»
»
»
»
» Its one of the “big four” essential oils that was used for hairloss for
» eons until the medical establishment came along and told us that “nothing
» works for baldness”. The four were cedarwood, rosemary, sage, and thyme.
» There are versions of this sold thesedays in thickening shampoos with
» menthol usually substitutiong for cedarwood (probably because of the more
» pleasant smell). I have a feeling this stuff probably worked to help
» someone keep what they had. I know peppermint is an effective
» anti-androgen for a fact. Ive seen that on my own beard hair. Sage is now
» in a few “hairloss” shampoos like American Crew Thickening and “Fuller,
» Thicker Hair Shampoo” along with menthol, rosemary, and thyme.

There is a group of herbs which have the potential to be very good at “lowering the immune reponse”

Regards
Pete


#3

http://www.fasebj.org/cgi/content/full/16/14/1967

The TGF-beta slowed keratinocyte growth by 50% with balding dermal papilla cells wehn they were given a synthetic androgen. Further tests revealed the culprit was TGF-beta 1…exactly what SAGE (salvia) seems to inhibit. Like I said…Cedarwood, Rosemary, Sage, and Lavender have been used for eons in the past (especially Cedarwood, which mummies in Scotland were found to have in their hair from the Iron age in a peat bog—all of whom apparently had good hair). It probably helps a good deal. Thyme has been shown to inhibit some prostaglandins if I remember correctly and inhibit TNF-alpha and a few other chemcials also. Rosemary is a very potent anti-oxidant.

That is the study. Many think TGF-beta is the number one negative growth factor in human baldness.

Here is a pic of a guy who used apple poly (blocks tgf-beta) for 12 months:
(scroll down to photo), http://www.applepoly.com/procyanidin-b-2/


#4

» http://www.fasebj.org/cgi/content/full/16/14/1967
»
»
» The TGF-beta slowed keratinocyte growth by 50% with balding dermal papilla
» cells wehn they were given a synthetic androgen. Further tests revealed the
» culprit was TGF-beta 1…exactly what SAGE (salvia) seems to
» inhibit. Like I said…Cedarwood, Rosemary, Sage, and Lavender
» have been used for eons in the past (especially Cedarwood, which mummies
» in Scotland were found to have in their hair from the Iron age in a peat
» bog—all of whom apparently had good hair). It probably helps a good
» deal. Thyme has been shown to inhibit some prostaglandins if I remember
» correctly and inhibit TNF-alpha and a few other chemcials also. Rosemary
» is a very potent anti-oxidant.
»
»
»
» That is the study. Many think TGF-beta is the number one negative growth
» factor in human baldness.
»
»
» Here is a pic of a guy who used apple poly (blocks tgf-beta) for 12
» months:
» (scroll down to photo), http://www.applepoly.com/procyanidin-b-2/

Ive seen this before - my own logic tells me you need more than lowering the “immune response” via one pathway.
The herb you have mentioned is one of the herbs in the “Scottish study” I posted a while back.

Regards
Pete


#5

» » http://www.fasebj.org/cgi/content/full/16/14/1967
» »
» »
» » The TGF-beta slowed keratinocyte growth by 50% with balding dermal
» papilla
» » cells wehn they were given a synthetic androgen. Further tests revealed
» the
» » culprit was TGF-beta 1…exactly what SAGE (salvia) seems to
» » inhibit. Like I said…Cedarwood, Rosemary, Sage, and Lavender
» » have been used for eons in the past (especially Cedarwood, which
» mummies
» » in Scotland were found to have in their hair from the Iron age in a
» peat
» » bog—all of whom apparently had good hair). It probably helps a good
» » deal. Thyme has been shown to inhibit some prostaglandins if I remember
» » correctly and inhibit TNF-alpha and a few other chemcials also.
» Rosemary
» » is a very potent anti-oxidant.
» »
» »
» »
» » That is the study. Many think TGF-beta is the number one negative
» growth
» » factor in human baldness.
» »
» »
» » Here is a pic of a guy who used apple poly (blocks tgf-beta) for 12
» » months:
» » (scroll down to photo), http://www.applepoly.com/procyanidin-b-2/
»
»
» Ive seen this before - my own logic tells me you need more than lowering
» the “immune response” via one pathway.
» The herb you have mentioned is one of the herbs in the “Scottish study” I
» posted a while back.
»
»
»
»
» Regards
» Pete

I did not say that all you needed to inhibit was one pathway.
However I did say that some (Docj077 at HLT to be sure) think TGF beta is the most important of the antigens (thrombospodin, FGF-5, TGF beta, PKC, etc. of the dermal papilla negative growth factors, and the apple poly regrowth pic is one of the best Ive ever seen. Its claim to fame is the inhibition of TGF-beta as well as PKC.


#6

So would this be a good product to use ?

Linky

» [Effect of Salvia miltiorrhiza on autocrining growth factor by fibroblasts
» cultured in vitro][Article in Chinese]
»
»
» Wang YM, Wei FK, Liu M.
» Department of Pediatric Surgery, West China Hospital, Sichuan University,
» Chengdu Sichuan, P. R. China 610041.
»
» OBJECTIVE: To investigate the mechanism of overhealing alleviation by
» salvia miltiorrhiza (SM) in wound healing. METHODS: Fibroblasts were
» cultured in vitro, and SM was applied with different concentrations (40,
» 80, 160 and 320 micrograms/ml) and time(the 1st, 2nd, 3rd, 4th and 5th
» days) to influence their autocrine. The levels of transforming growth
» factor-beta 1 (TGF-beta 1) and epidermal growth factor (EGF) were
» determined by ELIAS and radioimmunoassay respectively. RESULTS: The SM
» could inhibit autocrine of TGF-beta 1 by fibroblasts (P < 0.05). However,
» it did not affect autocrine of EGF (P > 0.05). CONCLUSION: The above
» results indicate that SM reduces overhealing by inhibiting the autocrine
» of TGF-beta 1 selectively.
»
» PMID: 12508435 [PubMed - indexed for MEDLINE]
»
»
»
»
» Its one of the “big four” essential oils that was used for hairloss for
» eons until the medical establishment came along and told us that “nothing
» works for baldness”. The four were cedarwood, rosemary, sage, and thyme.
» There are versions of this sold thesedays in thickening shampoos with
» menthol usually substitutiong for cedarwood (probably because of the more
» pleasant smell). I have a feeling this stuff probably worked to help
» someone keep what they had. I know peppermint is an effective
» anti-androgen for a fact. Ive seen that on my own beard hair. Sage is now
» in a few “hairloss” shampoos like American Crew Thickening and “Fuller,
» Thicker Hair Shampoo” along with menthol, rosemary, and thyme.


#7

» So would this be a good product to use ?
»
»YIKES, did you see how much money they wanted for that little bottle. Dude, you can buy entire bottles of each essential oil for about ten bucks each…and use grapeseed oil or jojoba as a carrier…

Cedarwood is the “first” hairgrowth essential oil that is in most of the old remedies, sage, rosemary, and thyme are the next ones. They are what was used in the Scottish dermatology study for alopecia areata. They’d last a long, long time. Cedarwood and rosemary and sage are all soluble in alcohol (ethanol) also.


#8

» So would this be a good product to use ?
»
» Linky
» http://www.nativeremedies.com/regrow-oil-herbal-balding-solution.html
»
»
» » [Effect of Salvia miltiorrhiza on autocrining growth factor by
» fibroblasts
» » cultured in vitro][Article in Chinese]
» »
» »
» » Wang YM, Wei FK, Liu M.
» » Department of Pediatric Surgery, West China Hospital, Sichuan
» University,
» » Chengdu Sichuan, P. R. China 610041.
» »
» » OBJECTIVE: To investigate the mechanism of overhealing alleviation by
» » salvia miltiorrhiza (SM) in wound healing. METHODS: Fibroblasts were
» » cultured in vitro, and SM was applied with different concentrations
» (40,
» » 80, 160 and 320 micrograms/ml) and time(the 1st, 2nd, 3rd, 4th and 5th
» » days) to influence their autocrine. The levels of transforming growth
» » factor-beta 1 (TGF-beta 1) and epidermal growth factor (EGF) were
» » determined by ELIAS and radioimmunoassay respectively. RESULTS: The SM
» » could inhibit autocrine of TGF-beta 1 by fibroblasts (P < 0.05).
» However,
» » it did not affect autocrine of EGF (P > 0.05). CONCLUSION: The above
» » results indicate that SM reduces overhealing by inhibiting the
» autocrine
» » of TGF-beta 1 selectively.
» »
» » PMID: 12508435 [PubMed - indexed for MEDLINE]
» »
» »
» »
» »
» » Its one of the “big four” essential oils that was used for hairloss for
» » eons until the medical establishment came along and told us that
» “nothing
» » works for baldness”. The four were cedarwood, rosemary, sage, and
» thyme.
» » There are versions of this sold thesedays in thickening shampoos with
» » menthol usually substitutiong for cedarwood (probably because of the
» more
» » pleasant smell). I have a feeling this stuff probably worked to help
» » someone keep what they had. I know peppermint is an effective
» » anti-androgen for a fact. Ive seen that on my own beard hair. Sage is
» now
» » in a few “hairloss” shampoos like American Crew Thickening and “Fuller,
» » Thicker Hair Shampoo” along with menthol, rosemary, and thyme.

I have no doubt that some Essential oil blends may lower the “immune response”, so if you want to acheive this stick to the blend in the Scottish study.

If you want to achieve real regrowth a topical that increases SOD, reduces inflammation and increases bloodflow would help.

A shampoo that contains Pirctone Olamine and boosts bloodflow ( menthol ) would also help.

Regards
Pete


#9

» [Effect of Salvia miltiorrhiza on autocrining growth factor by fibroblasts
» cultured in vitro][Article in Chinese]
»
»
» Wang YM, Wei FK, Liu M.
» Department of Pediatric Surgery, West China Hospital, Sichuan University,
» Chengdu Sichuan, P. R. China 610041.
»
» OBJECTIVE: To investigate the mechanism of overhealing alleviation by
» salvia miltiorrhiza (SM) in wound healing. METHODS: Fibroblasts were
» cultured in vitro, and SM was applied with different concentrations (40,
» 80, 160 and 320 micrograms/ml) and time(the 1st, 2nd, 3rd, 4th and 5th
» days) to influence their autocrine. The levels of transforming growth
» factor-beta 1 (TGF-beta 1) and epidermal growth factor (EGF) were
» determined by ELIAS and radioimmunoassay respectively. RESULTS: The SM
» could inhibit autocrine of TGF-beta 1 by fibroblasts (P < 0.05). However,
» it did not affect autocrine of EGF (P > 0.05). CONCLUSION: The above
» results indicate that SM reduces overhealing by inhibiting the autocrine of
» TGF-beta 1 selectively.
»
» PMID: 12508435 [PubMed - indexed for MEDLINE]
»
»
»
»
» Its one of the “big four” essential oils that was used for hairloss for
» eons until the medical establishment came along and told us that “nothing
» works for baldness”. The four were cedarwood, rosemary, sage, and thyme.
» There are versions of this sold thesedays in thickening shampoos with
» menthol usually substitutiong for cedarwood (probably because of the more
» pleasant smell). I have a feeling this stuff probably worked to help
» someone keep what they had. I know peppermint is an effective anti-androgen
» for a fact. Ive seen that on my own beard hair. Sage is now in a few
» “hairloss” shampoos like American Crew Thickening and “Fuller, Thicker Hair
» Shampoo” along with menthol, rosemary, and thyme.

Coincidentally without seeing this thread I bought this today: http://www.worldofhair.com/hair/alopecia-areata.htm


#10

I’ve been using essential oils for 5+ years twice daily. I think it has helped me though I don’t think I would have achieved regrowth without upping my finasteride dosage. Regarding sage, there are two different sages: salvia officinalis, the most common one . and salvia sclarea, claimed as being the most active one in terms of possible regrowth. I use both along with the other three mentionned oils plus some more (lavender, tea tree, pine, ylang ylang) diluted in rhum. Then massage my scalp then use minox.


#11

Adv Ther. 2003 Jul-Aug;20(4):220-9

Essential oils and low-intensity electromagnetic pulses in the treatment of androgen-dependent alopecia

This double-blind randomized study vs placebo in healthy male and female volunteers demonstrates the positive biologic effect on hair loss and hair regrowth of a pulsed electromagnetic field in combination with essential oils administered according to a regular treatment schedule of 26 weeks. Mean hair count comparisons within the groups significantly favor the treatment group, which exhibited a decrease in hair loss in 83% of the volunteers and a more than 20% hair count increase over baseline in 53% of patients.

The process exhibited no side effects or untoward reactions. The histologic examination correlated with the clinical study. A parallel immunohistochemical examination showed an increase in the proliferation index, and when the expression of Ki67 (a cell proliferation marker) is increased, the mitoses are barely visible in the histologic examination. The rationale of this phenomenon is considered to be due to an electrophysiologic effect on the quiescent hair follicle.


#12

:lookaround:

So . . .

Who has tried applying a daily Applepoly topical onto a harsh scalp abrasion of some sort, and with the addition of a lithium chloride topical for about a week starting on the fourth day?

Doesn’t that sound like it would be getting pretty close to Follica’s plan?

:wink:


#13

Benji and the others,

sorry to drift a little away from the topic but what TGF beta inhibitors would be most efficient in scar prevention? Some tip any of us could apply to avoid scar formation after a bruise or a wound any where on the body?


#14

» :lookaround:
»
» So . . .
»
» Who has tried applying a daily Applepoly topical onto a harsh scalp
» abrasion of some sort, and with the addition of a lithium chloride topical
» for about a week starting on the fourth day?
»
»
» Doesn’t that sound like it would be getting pretty close to Follica’s
» plan?
»
» :wink:

god no, nowhere near it. read the patent thouroughly for yourself and take notes–there is nothing about tgf-beta inhibtion at all therein. antihistamines antiandrogens minoxidil egf receptor antagonists-most prominent-minoxidil anti-microbials down the line…as much as possible would probably better be administered internally to be honest…starting about three days post wounding and even two days post when it comes to the arava (an arthritis pill—so its not going to hurt anyone). The lithium isn’t really even mentioned in the patent,but lithium chloride used to be used as a table salt adjunct and a little of it could be eated daily on an apple or whatever…or garlic tablets could be taken to up that post-re-epilithialization at around day five post wounding…

if you really want to ‘try it at home’ (im probably going to just wait for follica’s tests, they dont even know if it will work yet until they try it) its imperative that it gets done right or someone will just be scratching up their head deeply and painfully ----skin is supposed to be pink and almost shiny which is more than a mere microdermabrasion—for nothing

from the vaugue verbiage in the patent 9intentional in my opinion9…no washing of the treated area probably needs to take place for severeal days and hair proper could be cleaned with something like alcohol-soaked paper towels while hanging away from the scalp—not touching the scalp proper----no ointments or anti-infectives are to be used…i dont think i’d risk shampooing because the chemicals therein might phuck up aforesaid process…patent is vague probably very much on purpose because they dont want anyone doing this at home


#15

Well, I didn’t mean my list there would LITERALLY dupe the Follica work. I was speaking generally. I don’t really intend to take a belt-sander and a bottle of applejuice to my head just yet. I’m just blue-sky thinking here.

If the Follica method testing starts shaping up to look like it’s really gonna work, maybe there’s some less-exotic substances out there that would make good topicals for a lesser round of the idea. Something to monkey with while we’re waiting around for this expensive new procedure to get through the red tape. Like maybe try a moderate abrasion on a small spot, and then see what happens with some topicals that have similar properties to the Follica stuff.

But doesn’t applepoly have some EGF-R blocking effects?


#16

Benji, cal, can you answer my probably naive question?
Thank you.


#17

About scarring?

Unfortunately I don’t know enough about that subject to comment. I’ve read mostly about the hair effects of things we’re discussing lately.


#18

I can remember reading that TGF beta had to be inhibited to avoid or at least minimize the formation of scar tissue. Hence my question: what tgf beta inhibitor would be best at doing this? Benji any idea?


#19

» I can remember reading that TGF beta had to be inhibited to avoid or at
» least minimize the formation of scar tissue. Hence my question: what tgf
» beta inhibitor would be best at doing this? Benji any idea?

tgf-beta inhibition supposedly will help against the excessive collagenouse deposition around the follicle…the usual substances discussed are curcumoids, bromelain, apple B-2 proanthocyandins…black tea and sage have been found in some experiments to suppress that pathway.

If you have alot of collagen up there (shiny scalp), prox-n’s SOD’s help with that over time. You can look at Bryan’s pictures at the photo gallery at hairlosstalk and see that. Copper peptides and emu oil together help with scars over time…but it takes a good deal of time (years).


#20

While the subject has come up, is there any preferred source of copper peptides for topicals?

CP’s are in a zillion commercial skin creams, but I suspect they’re probably overpriced stuff in low concentrations.