» Yeah the difference is when u say something is a DHT blocker like Propecia,
» is that propecia binds to the androgen hormone in your blood and
» systemically stops any of the DHT binding with anything else that is can
» attach to lik androgen receptors in your skin or brain, ie. it inactivates
» the DHT so it cannot bind to anyhing.
Nope. Propecia was designed to prevent conversion of T to DHT by impacting the 5AR enzyme. There are 2 types of 5AR, both are genetically encoded. You may be thinking about Sex-Hormone-Binding-Globulin (SHBG), which is related to hairloss but in a very convoluted way.
» Whereas nizoral topical works topical by stopping the DHT from attaching
» to the androgen receptor locally. So it is blocking DHT but in a different
» and in my opinion better way by doing it at the receptor.
Nope. Nizoral (Ketoconazole) does what Propecia does, but it blocks more CYP450 enzymes (5AR is one/two) and therefore blocks many other hormones from developing, e.g. Estrogen also.
» So i think its better if we clarify that and not confuse it with other DHT
» blockers like FIN and DUT.
Here I agree. Clarity is good.
» Nizoral works by suppressing the androgen receptors in the scalp
I have not seen reserach that suggests this as a secondary mode of action for Nizoral but will read the Japanese study. I have research Nizoral/Keto extensively.
» And also has a non androgenetcic growth promoting ability that has yet to
» be scientifically understood.
Nope. Nizoral/Keto impact on androgens is very clearly understood. I have read many, many papers on this. It is simply a CYP450 inhibitor.
» When ketoconaozle is taken internally it will have DHT blocking like FIN
» and Dut
Nope. It’s gonna completely screw your hormone balance (HPTA-axis and also Thyroid) and you destroy your liver to the bargain.
» » » If you look at the recent Japan nizoral study they say it works by
» » » » suppressing the androgen receptor and also by being a non androgen
» » » related
» » » » growth stimulator. So its not blocking DHT like propecia does.
» » »
» » » “suppressing the androgen receptor” = blocking DHT.
» » »
Nope. For complete clarity suppressing the androgen receptor is not the same as blocking DHT. Close but not exact.
Certain drugs can reduce/increase the number of androgen receptors, e.g. Rhetinoic Acid reduces the overall number of andgrogen receptors. This is receptor suppression in miy mind.
Receptor blocking is where the same number of receptors exist, but a substance is introduced that preferentially binds to the receptor and blocks the default compund from binding. In this case if we stop DHT binding to the T-receptor we stop the cascade of chemical reactions that follow; release of the Heat Shock Protein and local DNA modification.
There has been far less work on the T-receptor than the E-receptors (there are 2 in hair); this is because E-receptors are central to cancer research. Drugs named Specific-Estrogen-Receptor-Modulators (SERMs) are the output of this. Care needs to be taken as SERMs may have very different effects at different body locations. Tamoxifen is a SERM that blocks the E-receptor in breast cells.
» » » DHT is an androgen. Supressing the receptor is stopping it from
» » » receptive to androgens (DHT), ie. blocking androgens (DHT).
» » agreed that is whey they are called DHT blockers,
DHT blockers is a term used in hairloss discussions; scientific research is much more precise and the term is not used.