I trust Histogen

Stem cell; cell based hair therapy
1

Good news from Histogen, guys: http://www.histogen.com/aboutus/news_events.htm#38

Just few lines:

“significant increase in vellus hair count (p=0.033) was seen for the first time, supporting the hypothesis that the HSC treatment rescues dying follicles, in addition to converting vellus to terminal hairs and increasing the number of hairs per follicle. Statistical significance continued to be seen at the 24 week time point.”

“Particularly compelling is the growth seen in more difficult types and stages of hair loss. Without limitations to treatment area, age or stage of balding, HSC has the potential to expand the hair restoration market by offering a successful option to those that currently have none.”

“In both the pilot and Phase I/II clinical trial, HSC treatment has shown efficacy across age groups, with subjects age 40-59 seeing cosmetically significant results beginning at 12 weeks, including a mean increase of 39% in terminal hairs and 19.4% in total hair count in this age group in the current trial.”

“Subjects receiving HSC in the temporal recession , which is known to be more difficult to treat than other areas of hair loss, saw marked improvement in terminal hair count, with a mean increase of 22.6% at 12 weeks and 25.2% at the 24 week time point.”

Those news seem exciting…I really hope that everything will go in the proper way however I’ve always been trusting Histogen :slight_smile:

2

goog for them

3

Thanks for sharing this. It’s great news that histogen is moving forward, and it seems they are achivieng mantainance and improvement with bigger doses.
Hopefully they will have something useful even for people with extensive hairloss.

4

» Good news from Histogen, guys:
» http://www.histogen.com/aboutus/news_events.htm#38
»
» Just few lines:
»
» “significant increase in vellus hair count (p=0.033) was seen for the first
» time, supporting the hypothesis that the HSC treatment rescues dying
» follicles, in addition to converting vellus to terminal hairs
» and increasing the number of hairs per follicle. Statistical
» significance continued to be seen at the 24 week time point.”
»
» “Particularly compelling is the growth seen in more difficult types and
» stages of hair loss. Without limitations to treatment area, age or stage
» of balding, HSC has the potential to expand the hair restoration market
» by offering a successful option to those that currently have none.”
»
» “In both the pilot and Phase I/II clinical trial, HSC treatment has shown
» efficacy across age groups, with subjects age 40-59 seeing
» cosmetically significant results beginning at 12 weeks, including a mean
» increase of 39% in terminal hairs and 19.4% in total hair count in this age
» group in the current trial.”
»
» “Subjects receiving HSC in the temporal recession , which is
» known to be more difficult to treat than other areas of hair loss, saw
» marked improvement in terminal hair count, with a mean increase of 22.6% at
» 12 weeks and 25.2% at the 24 week time point.”
»
» Those news seem exciting…I really hope that everything will go in the
» proper way however I’ve always been trusting Histogen :slight_smile:

I have been saying all along that Histogen is likely a breakthrough success and that fool Iron_man has been sharply attacking me for saying so. Also, KO has said negative things about Histogen and of course he will now try to act like he’s been supportive of Histogen all along.

5

Hair loss will be cured by 2015.

We will put together a home-brew GPR44 blocker that may cure hair loss within the next few months but if that doesn’t work then Histogen will definitely cure hair loss by 2015.

Anyone who gets a hair transplant at this point is a fool. Histogen will give you back what you had before hair loss started and it will do so in 2015. Some will say that the new study results do not yield a 100% reversal of hair loss but the results are compoundable and you could get more than one injection and that would likely yield better results.

Baldness is almost cured - either it’s cured now by home-brew GPR44 blocker or it’s cured in about 2 years from Histogen.

6

» Hair loss will be cured by 2015.
»
» We will put together a home-brew GPR44 blocker that may cure hair loss
» within the next few months but if that doesn’t work then Histogen will
» definitely cure hair loss by 2015.
»
» Anyone who gets a hair transplant at this point is a fool. Histogen will
» give you back what you had before hair loss started and it will do so in
» 2015. Some will say that the new study results do not yield a 100%
» reversal of hair loss but the results are compoundable and you could get
» more than one injection and that would likely yield better results.
»
» Baldness is almost cured - either it’s cured now by home-brew GPR44 blocker
» or it’s cured in about 2 years from Histogen.

What’s the timeline like if all goes swimmingly, for this stuff to be available?

And let’s hope that this stuff doesn’t wear off after you use it for a few years, like Rogaine does.

7

» » Hair loss will be cured by 2015.
» »
» » We will put together a home-brew GPR44 blocker that may cure hair loss
» » within the next few months but if that doesn’t work then Histogen will
» » definitely cure hair loss by 2015.
» »
» » Anyone who gets a hair transplant at this point is a fool. Histogen
» will
» » give you back what you had before hair loss started and it will do so in
» » 2015. Some will say that the new study results do not yield a 100%
» » reversal of hair loss but the results are compoundable and you could get
» » more than one injection and that would likely yield better results.
» »
» » Baldness is almost cured - either it’s cured now by home-brew GPR44
» blocker
» » or it’s cured in about 2 years from Histogen.
»
» What’s the timeline like if all goes swimmingly, for this stuff to be
» available?
»

Even if everything goes perfect you can still count on a couple years. They have to do a phase 2 study and then a phase 3 study. That will be either 12 months if each study is 6 months or else 2 years if each study is 1 year. Then it will take a few months after that to come to market somewhere in the world. You’re looking at availability in mid 2014 to mid 2015.

» And let’s hope that this stuff doesn’t wear off after you use it for a few
» years, like Rogaine does.

You might have to get injections again after a few years or maybe every 5 years. No biggie!

8

The only chance I see before 2015 is the following:

  1. Our own home-brews of GPR44 blockers and PGE2 stimulators. I think this is hopeful but it may turn out to be a dead end.

  2. Allergan’s bimatoprost studies.

Other than these 2 possibilities it looks to me like it’s Histogen somewhere between mid-2014 and mid-2015.

Can you think of anything else???

9

A combination of CB-03-01, Histogen and PGD2 blocker will be a very promising combo for fighting baldness. The only problem I see is the crappy 5 years timeline away, which can be even more if the current regulatory process for new drugs stays the same.

10

What 5 year timeline? Last I heard even Histogen was saying that their technology could be available in 2015.

And you won’t need all this other stuff with Histogen such as a PGD2 blocker or CB-03-01. The most you would need to add is minoxidil, if even that. But by the same token if the PGD2 blocker works then the only other thing you would need to add to the PGD2 blocker would be a way to increase PGE2. And for the record, when you say PGD2 blocker I’m assuming that you mean a GPR44 blocker.

» A combination of CB-03-01, Histogen and PGD2 blocker will be a very
» promising combo for fighting baldness. The only problem I see is the crappy
» 5 years timeline away, which can be even more if the current regulatory
» process for new drugs stays the same.

11

» » And let’s hope that this stuff doesn’t wear off after you use it for a
» few
» » years, like Rogaine does.
»
»
» You might have to get injections again after a few years or maybe every 5
» years. No biggie!

I hope you’re right about the worst case being that of having more injections should the effect ever wear off.

But the body has a way of adjusting itself to man-made interventions, like Rogaine, so that after a while the intervention in question no longer has an effect.

But I’d be happy if I got a couple or three years out of it at least, which may keep me until HM comes to market, if ever.

12

The body doesn’t adjust to Rogaine, the problem is that the stuff never actually fought the MPB process. It just provided some offset growth. Eventually you’re back below baseline because the MPB process never even slowed down.

Fin/Dut don’t have perfect consistent long term records by any means. But it does seem clear that they will leave most patients with a lot more hair in the long term than nature intended for them to have. At least those patients who can handle the side effects well enough to stay on the drug for many years.

13

I think you’re right about Histogen, AleMB81. Histogen’s HSC might not itself be the silver bullet cure, but this is the only company with a product in development which has showed concrete evidence that it can regrow a substantial amount of hair.

I wonder what Freddie555 has to say about Histogen. Clearly, it would contradict his theory that the only route to regrowing most of your hair is via some form of cell-based technology. (Full disclosure: I used to basically hold this opinion too, before Histogen and before Dr. Cotsarelis’ discovery of PGD2’s role.)

Freddie says that blocking PGD2 receptors can’t be the solution by itself because, assuming the PGD2 mechanism relies on cells healthy enough to keep producing the PGD2, empirically, we’ve never seen any anecdotes of where the PGD2 mechanism fails with old age, resulting in regrowth of scalp hair.

I understand his point, although it could be that it’s very hard to turn off this “one way genetic switch” for PGD2 Synthase which I believe may be activated by DHT. Obviously in old age, circulating DHT levels (along with free Testosterone levels) go down. Maybe the one-way gene switch for PGD2 Synthase that I’ve suggested is something so powerful or “immune” from assault that even old age and cell senescence can’t turn off.

Another possibility is that after the follicles have been miniaturized a long time, the nearby muscles (erector pili), blood vessels (capillaries), etc. atrophy along with the follicle, so that even if levels of PGD2 go down (for any reason), the follicles’ support systems are no longer present, and that becomes problematic if the follicle is trying to reconstitute itself or enlarge.

A way around that might be to use a PGD2 receptor blocker along with Histogen’s product. HSC contains numerous growth factors including VEGF, vascular endothelial growth factor – which may help revive surrounding micro-vasculature. Some of the Histogen growth factors might also help revive the erector pili muscles.

I can’t help thinking that a PGD2 receptor blocker + Histogen would be a very powerful hair regeneration strategy.

14

Roger_that: yes probably Histogen is not a cure but could be a really good booster for hair regrowth.

what i think is that follicle does not die (I posted an article saying that follicles producing vellus hair where grafted into the skin of mice with immunodeficiency and they were able to produce terminal hair) so probably by lowering PGD2 and boosting the regrowth with Histogen we could have a really nice result without any side…

Now what we have to wait the official results of Histogen (phase II is ending) which should be published within the year end…

However there only two options: 1) PGD2 inibhitors + Histogen will be barely a cure; 2) We are f*cked :smiley:

15

One thing I don’t understand about HSC is why is the project an injectible rather than a topical?

It seems that the effects would be best with daily application, not e.g. one application every six months.

I know they’re using a “soup” of various growth factors, but molecules of this type aren’t likely to have a very long half-life in the tissues. It’s likely that after a few days, they may be diluted, dispersed from the target tissues by the circulation, or metabolized, meaning they really remain in the follicles intact for much less time than needed.

If you notice every other pharmaceutical treatment for hair loss (whether topical or per-oral) requires at least once daily dosing. For topicals it’s usually twice a day.

Histogen is a sub-epidermal injection which is ESSENTIALLY a topical.

Why did they choose this rather weird method of application – injecting chemicals into the skin – rather than a topical lotion?

16

» One thing I don’t understand about HSC is why is the project an injectible
» rather than a topical?

Back in 08 there was talk of a shampoo.
That was contingent on the successful development of their HSC product of course.

Conceivably – in the future – you could get a higher dose of HSC via an injectable treatment, and maintain your results via a shampoo or some type of topical.

17

» » One thing I don’t understand about HSC is why is the project an
» injectible
» » rather than a topical?
»
» Back in 08 there was talk of a shampoo.
» That was contingent on the successful development of their HSC product of
» course.
»
» Conceivably – in the future – you could get a higher dose of HSC via an
» injectable treatment, and maintain your results via a shampoo or some type
» of topical.

Injectible is much more effective then shampoo in my opinion. I rather have them inject their HSC every five years then have a shampoo where i dont know if it works.

There is also a chance that your hairs maybe remain resitent to DHt or whatever cause hair loss.

The only thing in their recent release which was interesting was the fact that they got hairs on the temple regions.

Nevertheless people with traditional transplants are fu**ed because their follicles in the recipient are are dead and destroyed. Or does anyone here think that Histogen could work on topcat for example?

Future will be like

Gho,Histogen and this PDG2 whatever blocker and after that its team tokyo

But i wont expect anything from Aderans or Replicel.

Evyeryone under 30 will benefit from future technologies but i dont know why Ahab (this guy is over 50 or so) is still obsessed with hair loss? He cant benefit from anything, he is old

18

» Evyeryone under 30 will benefit from future technologies but i dont know
» why Ahab (this guy is over 50 or so) is still obsessed with hair loss? He
» cant benefit from anything, he is old

F.U.

And I don’t know why short ugly guys bother about hair loss. They can’t benefit from anything; they’re short and ugly.

Amd I’m over sixty, just to set the record straight.

19

» Evyeryone under 30 will benefit from future technologies but i dont know
» why Ahab (this guy is over 50 or so) is still obsessed with hair loss? He
» cant benefit from anything, he is old.

Hairloss affects people of all age groups, and life doesn’t end after you hit 30, 40, 50, 60, etc…

20

»
» Hairloss affects people of all age groups, and life doesn’t end after you
» hit 30, 40, 50, 60, etc…

Exactly.

There are balding 20yo guys on the forums trying to justify getting Armani hairlines by saying “I won’t care how I look when I’m 25 or 30.”

The idea that you will one way wake up and stop being bothered by MPB is a myth. If it bothers you enough to bring you here today, then it always will.