Audio interview with Dr. Gail Naughton, CEO of Histogen.
About the safety trial, 1 year results.
very interesting.
I think it has not been posted before?
summary:
Safety Trial: 25 patients, no adverse reactions. best results with no wounding, and no animal proteins.
At 12 months, hair numbers keep increasing.
Neogenesis+rejuvenation, it seems (not sure).
Plans:
Phase I-II Singapore fall 2010 50 patients, higher dose-
at12week endpoint ->start preparing phaseIII 250 patients. 5-country pan-Asia.
Approval in Asia in 2.5 or 3 years
Will possibly work in women, and in any type of hairloss, including Alopecia Areata.
» Audio interview with Dr. Gail Naughton, CEO of Histogen.
» About the safety trial, 1 year results.
» very interesting.
» I think it has not been posted before?
»
» summary:
» Safety Trial: 25 patients, no adverse reactions. best results with no
» wounding, and no animal proteins.
» At 12 months, hair numbers keep increasing.
» Neogenesis+rejuvenation, it seems (not sure).
»
» Plans:
» Phase I-II Singapore fall 2010 50 patients, higher dose-
» at12week endpoint ->start preparing phaseIII 250 patients. 5-country
» pan-Asia.
» Approval in Asia in 2.5 or 3 years
»
» Will possibly work in women, and in any type of hairloss, including
» Alopecia Areata.
»
» crisis? what crisis?
It seems the board is acting strangely tonight, I didn’t see this thread before. I left this same comment in the other Histogen thread, It’s just little more info from someone at Histogen in the comments of the link SD left.
The question from someone was.
Histogen says the % change from Baseline to 1 year is +73.61%… but 179 hairs to 263 hairs is only a +47.21% increase, is it not?
And this was the response from Histogen
John,
Thank you for your comment. You are correct, the numbers shown in the slides do show a 47.21% increase (179 to 263) which represents the increase in total hair count. In reviewing the actual numbers in the clinical data, the 73.61% increase is actually the increase in the terminal hairs in that subject. So, the numbers on the slide are correct - however, they relate to two different parameters measured (Total Hair Count and Terminal Hair Count).
We also saw statistical significance in multiple efficacy endpoints including Total Hair Count, Terminal Hair Count, Thickness and Hair Thickness Density. Also measured were Velus hair count, rate of growth, etc. Thank you for your astute observation. I think you would agree that this is very exciting considering it was an injection at baseline only.
Dr. Hubka
Director of Clinical Affairs
Histogen, Inc.
» It seems the board is acting strangely tonight, I didn’t see this thread
» before. I left this same comment in the other Histogen thread, It’s just
» little more info from someone at Histogen in the comments of the link SD
» left.
»
» The question from someone was.
»
» Histogen says the % change from Baseline to 1 year is +73.61%…
» but 179 hairs to 263 hairs is only a +47.21% increase, is it not?
»
» And this was the response from Histogen
»
» John,
»
» Thank you for your comment. You are correct, the numbers shown in the
» slides do show a 47.21% increase (179 to 263) which represents the increase
» in total hair count. In reviewing the actual numbers in the clinical data,
» the 73.61% increase is actually the increase in the terminal hairs in that
» subject. So, the numbers on the slide are correct - however, they relate to
» two different parameters measured (Total Hair Count and Terminal Hair
» Count).
» We also saw statistical significance in multiple efficacy endpoints
» including Total Hair Count, Terminal Hair Count, Thickness and Hair
» Thickness Density. Also measured were Velus hair count, rate of growth,
» etc. Thank you for your astute observation. I think you would agree that
» this is very exciting considering it was an injection at baseline only.
»
» Dr. Hubka
» Director of Clinical Affairs
» Histogen, Inc.
This is actually a pretty detailed and honest answer. And important here is that it is actually better then expected.
I bet they were in such a happy mood that they totally forgot about put this in their sheet ^^
So we can say There is an additinal hair grow to the hair and a lot more terminal hair, which means all our thin and diffuse hair will be terminal again, most of them, and there is additional hair?
I wonder what will happen in totally bald areas. (47% of zero is zero).
I hope this is tested on the next trials.
» » It seems the board is acting strangely tonight, I didn’t see this thread
» » before. I left this same comment in the other Histogen thread, It’s
» just
» » little more info from someone at Histogen in the comments of the link
» SD
» » left.
» »
» » The question from someone was.
» »
» » Histogen says the % change from Baseline to 1 year is
» +73.61%…
» » but 179 hairs to 263 hairs is only a +47.21% increase, is it
» not?
» »
» » And this was the response from Histogen
» »
» » John,
» »
» » Thank you for your comment. You are correct, the numbers shown in the
» » slides do show a 47.21% increase (179 to 263) which represents the
» increase
» » in total hair count. In reviewing the actual numbers in the clinical
» data,
» » the 73.61% increase is actually the increase in the terminal hairs in
» that
» » subject. So, the numbers on the slide are correct - however, they relate
» to
» » two different parameters measured (Total Hair Count and Terminal Hair
» » Count).
» » We also saw statistical significance in multiple efficacy endpoints
» » including Total Hair Count, Terminal Hair Count, Thickness and Hair
» » Thickness Density. Also measured were Velus hair count, rate of growth,
» » etc. Thank you for your astute observation. I think you would agree
» that
» » this is very exciting considering it was an injection at baseline only.
» »
» » Dr. Hubka
» » Director of Clinical Affairs
» » Histogen, Inc.
»
»
» This is actually a pretty detailed and honest answer. And important here
» is that it is actually better then expected.
»
» I bet they were in such a happy mood that they totally forgot about put
» this in their sheet ^^
»
» So we can say There is an additinal hair grow to the hair and a lot more
» terminal hair, which means all our thin and diffuse hair will be terminal
» again, most of them, and there is additional hair?
I think you’ll grow about 80 hairs and that will be a 8000% increase. I think the better question is "what was the dimensions of the test area? Did this growth happen per cm2, in2 or over the entire head.
» I wonder what will happen in totally bald areas. (47% of zero is zero).
» I hope this is tested on the next trials.
»
» » » It seems the board is acting strangely tonight, I didn’t see this
» thread
» » » before. I left this same comment in the other Histogen thread, It’s
» » just
» » » little more info from someone at Histogen in the comments of the link
» » SD
» » » left.
» » »
» » » The question from someone was.
» » »
» » » Histogen says the % change from Baseline to 1 year is
» » +73.61%…
» » » but 179 hairs to 263 hairs is only a +47.21% increase, is it
» » not?
» » »
» » » And this was the response from Histogen
» » »
» » » John,
» » »
» » » Thank you for your comment. You are correct, the numbers shown in the
» » » slides do show a 47.21% increase (179 to 263) which represents the
» » increase
» » » in total hair count. In reviewing the actual numbers in the clinical
» » data,
» » » the 73.61% increase is actually the increase in the terminal hairs in
» » that
» » » subject. So, the numbers on the slide are correct - however, they
» relate
» » to
» » » two different parameters measured (Total Hair Count and Terminal Hair
» » » Count).
» » » We also saw statistical significance in multiple efficacy endpoints
» » » including Total Hair Count, Terminal Hair Count, Thickness and Hair
» » » Thickness Density. Also measured were Velus hair count, rate of
» growth,
» » » etc. Thank you for your astute observation. I think you would agree
» » that
» » » this is very exciting considering it was an injection at baseline
» only.
» » »
» » » Dr. Hubka
» » » Director of Clinical Affairs
» » » Histogen, Inc.
» »
» »
» » This is actually a pretty detailed and honest answer. And important
» here
» » is that it is actually better then expected.
» »
» » I bet they were in such a happy mood that they totally forgot about put
» » this in their sheet ^^
» »
» » So we can say There is an additinal hair grow to the hair and a lot
» more
» » terminal hair, which means all our thin and diffuse hair will be
» terminal
» » again, most of them, and there is additional hair?
» » » Audio interview with Dr. Gail Naughton, CEO of Histogen.
» »
» »
» » where is it ???
»
» No talking around it.
»
» Does this mean, everone can have his full head of hair with a high density
» back?
»
» This is the only Question we should ask, nothing more
I haven’t been on there website in awhile but it looks like they posted everything she talked about in the interview. They also posted a release date of 2015.
» » » Audio interview with Dr. Gail Naughton, CEO of Histogen.
» »
» »
» » where is it ???
»
» No talking around it.
»
» Does this mean, everone can have his full head of hair with a high density
» back?
»
» This is the only Question we should ask, nothing more
» I haven’t been on there website in awhile but it looks like they posted
» everything she talked about in the interview. They also posted a release
» date of 2015.
»
»
» » » » Audio interview with Dr. Gail Naughton, CEO of Histogen.
» » »
» » »
» » » where is it ???
» »
» » No talking around it.
» »
» » Does this mean, everone can have his full head of hair with a high
» density
» » back?
» »
» » This is the only Question we should ask, nothing more
» » I haven’t been on there website in awhile but it looks like they posted
» » everything she talked about in the interview. They also posted a
» release
» » date of 2015.
» »
» »
» » » » » Audio interview with Dr. Gail Naughton, CEO of Histogen.
» » » »
» » » »
» » » » where is it ???
» » »
» » » No talking around it.
» » »
» » » Does this mean, everone can have his full head of hair with a high
» » density
» » » back?
» » »
» » » This is the only Question we should ask, nothing more
»
» 2015? Wow thats a long long time
If it is definitely going to be here in 2015 and its going to be an outstanding treatment from norwood 3 to norwood 7 then i’m happy with that.
» » » I haven’t been on there website in awhile but it looks like they
» posted
» » » everything she talked about in the interview. They also posted a
» » release
» » » date of 2015.
» » »
» » »
» » » » » » Audio interview with Dr. Gail Naughton, CEO of Histogen.
» » » » »
» » » » »
» » » » » where is it ???
» » » »
» » » » No talking around it.
» » » »
» » » » Does this mean, everone can have his full head of hair with a high
» » » density
» » » » back?
» » » »
» » » » This is the only Question we should ask, nothing more
» »
» » 2015? Wow thats a long long time
»
»
» If it is definitely going to be here in 2015 and its going to be an
» outstanding treatment from norwood 3 to norwood 7 then i’m happy with that.
» » » » I haven’t been on there website in awhile but it looks like they
» » posted
» » » » everything she talked about in the interview. They also posted a
» » » release
» » » » date of 2015.
» » » »
» » » »
» » » » » » » Audio interview with Dr. Gail Naughton, CEO of Histogen.
» » » » » »
» » » » » »
» » » » » » where is it ???
» » » » »
» » » » » No talking around it.
» » » » »
» » » » » Does this mean, everone can have his full head of hair with a
» high
» » » » density
» » » » » back?
» » » » »
» » » » » This is the only Question we should ask, nothing more
nope i mean i hope it works for every stage on the norwood scale and brings it back to norwood 1 hopefully
» » »
» » » 2015? Wow thats a long long time
» »
» »
» » If it is definitely going to be here in 2015 and its going to be an
» » outstanding treatment from norwood 3 to norwood 7 then i’m happy with
» that.
»
» You mean Norwood 7 to Norwood 3
» » I haven’t been on there website in awhile but it looks like they posted
» » everything she talked about in the interview. They also posted a
» release
» » date of 2015.
» »
» »
» » » » » Audio interview with Dr. Gail Naughton, CEO of Histogen.
» » » »
» » » »
» » » » where is it ???
» » »
» » » No talking around it.
» » »
» » » Does this mean, everone can have his full head of hair with a high
» » density
» » » back?
» » »
» » » This is the only Question we should ask, nothing more
»
» 2015? Wow thats a long long time
Its always been five years away,five years away from 2005,2006,2007,2008,2009 and now from 2010 and more likely before that to!
» I haven’t been on there website in awhile but it looks like they posted everything she talked about in the interview. They also posted a release date of 2015.
» » I haven’t been on there website in awhile but it looks like
» they posted everything she talked about in the
» interview. They also posted a release date of 2015.
»
» What BS are you talking about??
The latest Interview clearly stated 2015 in the USA Dr Ziering stated this and he did give us some hints about upcoming problems
Also some other interesting facts which are not so extrem good but also not that bad.
» » » I haven’t been on there website in awhile but it looks
» like
» » they posted everything she talked about in the
» » interview. They also posted a release date of 2015.
» »
» » What BS are you talking about??
»
» The latest Interview clearly stated 2015 in the USA Dr Ziering stated
» this and he did give us some hints about upcoming problems
»
» Also some other interesting facts which are not so extrem good but also
» not that bad.
What BS are YOU talking about??
The “latest interview” with Dr. Craig Ziering & Spencer Kobrein has been August, 2009!
And the latest interview with Dr. Gail Naughton & Spencer Kobrein (Topic: “Continued Significant Hair Growth at One Year Follow-up” ) has been one month ago!
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