The word “HARVARD” should mean a lot to all of you.
That means this trial is serious business and the company is certainly no joke.
Only treating a small bald spot w/out any other adjuvants is a great way to see what pathways are activated in vivo with a human being in response to abrasion and if hair follicle placodes, cells, proto hairs start development without any chemical help at all.
Remember in Experiment 7 of the Patent, the one they were able to replicate, they simply abraded human skin grafted to a SCID mouse and were able to get hair germs by day 7. That was donor area skin though, obtained from strip-scar hair transplant clinics that would have been thrown away. This is bald MPB scalp----that sometimes has some micro-scarring from micro-inflammation due to the MPB immunological events over many years.
If they find pathway x or y is initiated in vivo in response to abrasion, CO2 lasers, soundwaves, chemical peels or whatever, they might be able to take away some of the adjuvants they feel are necessary to coax the epidermal stem cells to build new follicles------or they may find they need to add some other stimulatory compounds (fiberblast growth factor or topical beta catenin or whatever). This will be an excellent way to determine what exactly happens in the skin of live people in response to abrasion in MPB-scalp.
The fact that this is being done at Harvard after being researched at Penn should be very encouraging to everyone here.
BTW-------There are no ‘magic compounds’. If you read the patent, Follica tells you EXACTLY what they are considering using as adjuvants in a topical forumulation…EGF-antagonists, potassium channel openiers, Nitric Oxide agonists, retinoids, perhpaps immunosuppressants (they will no doubt be looking for particular immuno markers in skin in response to the wounding), anti-microbials, and anti-inflammatories, and possibly fiberblast growth factors like FGF7, and maybe beta catenin and wnt-protiens or wnt-mimetics like LiCl.
These experiments are a great way to see if some of those can be shed or another thing or two has to be added for EDIHN hairs to grow on MPB scalp as opposed to donor-area scalp etc.
The ball is rolling though…We had to wait three years for ICX to go from phase one to phase two while rolling our fingers.