Follica Trials Beginning Now: Follow the Link

» This sounds like the equivalent of a phase#1 test.
»
»
» “Let’s do one round this way first, just to make sure we’re not gonna kill
» anybody before we go any farther.”

how can they kill anybody with a simplie dermabrasion?! they are not doing what u said, they may wants to know better how the scalp respond to dermabrasion before they plan the next step of the trials

We must show in some way that we are eargerly waiting for this cure!! Ofcourse they know that al baldies are dying to have this cure, but the more we make them hear the better.

Let’s call or send Harvard a mail all together and ask info about this “trial”,

Yooooo I am happyyyyyyyy

I’ve been comming to this site for over 5 years. I’ve was here when JB, JTR, Maneless, Alecbaldone posted here often. This is the first time in a long time that I feel pretty positive that something will be on the market for us in the not too distant future. I have a good feeling about Acell and Follica. Lets keep our fingers crossed.

Take Care,
Bill

BostonBaldy… To answer your question… If you live in Boston, then 100% you should do it. If I lived there, I would be there without a doubt… No question about it… Worst case, you can tell us EXACTLY what method of ‘dermabrasion’ they use for those doing home tests…

» We must show in some way that we are eargerly waiting for this cure!!
» Ofcourse they know that al baldies are dying to have this cure, but the
» more we make them hear the better.
»
» Let’s call or send Harvard a mail all together and ask info about this
» “trial”,
»
» Yooooo I am happyyyyyyyy

sarcasm ?

So now we know they have begun trials what kind of trial do we think it is? - phase 0 - or does it look likely that they are pursuing a faster route to market…

or are we still in the dark?

» » This sounds like the equivalent of a phase#1 test.
» »
» »
» » “Let’s do one round this way first, just to make sure we’re not gonna
» kill
» » anybody before we go any farther.”
»
» how can they kill anybody with a simplie dermabrasion?! they are not doing
» what u said, they may wants to know better how the scalp respond to
» dermabrasion before they plan the next step of the trials

Guys, its a Research Study NOT a trial…they’re probably looking at the phisiology of the bald scalp so they can better design formulate their technique.

Yeah, I live in Boston but I don’t think I’ll do the study b/c my hair loss is at the front, not the back. In case there is scarring, I’d prefer not to have it in the front… though I would like to know the method, e.g., are they using a CO2 laser, fraxel laser, sandpaper (lol), what??

» BostonBaldy… To answer your question… If you live in Boston, then 100%
» you should do it. If I lived there, I would be there without a doubt… No
» question about it… Worst case, you can tell us EXACTLY what method of
» ‘dermabrasion’ they use for those doing home tests…

» The word “HARVARD” should mean a lot to all of you.

Yes, the “Harvard” connection is promising… though I expected it. Cotsarelis et al. I’m sure have friends in the dermatology department there.

» The word “HARVARD” should mean a lot to all of you.
»
»
» That means this trial is serious business and the company is certainly no
» joke.
»
»
» Only treating a small bald spot w/out any other adjuvants is a great way
» to see what pathways are activated in vivo with a human being in response
» to abrasion and if hair follicle placodes, cells, proto hairs start
» development without any chemical help at all.
»
»
» Remember in Experiment 7 of the Patent, the one they were able to
» replicate, they simply abraded human skin grafted to a SCID mouse and were
» able to get hair germs by day 7. That was donor area skin though, obtained
» from strip-scar hair transplant clinics that would have been thrown away.
» This is bald MPB scalp----that sometimes has some micro-scarring from
» micro-inflammation due to the MPB immunological events over many years.
»
»
» If they find pathway x or y is initiated in vivo in response to abrasion,
» CO2 lasers, soundwaves, chemical peels or whatever, they might be able to
» take away some of the adjuvants they feel are necessary to coax the
» epidermal stem cells to build new follicles------or they may find they need
» to add some other stimulatory compounds (fiberblast growth factor or
» topical beta catenin or whatever). This will be an excellent way to
» determine what exactly happens in the skin of live people in response to
» abrasion in MPB-scalp.
»
»
» The fact that this is being done at Harvard after being researched at Penn
» should be very encouraging to everyone here.
»
»
»
»
»
» BTW-------There are no ‘magic compounds’. If you read the patent, Follica
» tells you EXACTLY what they are considering using as adjuvants in a topical
» forumulation…EGF-antagonists, potassium channel openiers, Nitric Oxide
» agonists, retinoids, perhpaps immunosuppressants (they will no doubt be
» looking for particular immuno markers in skin in response to the wounding),
» anti-microbials, and anti-inflammatories, and possibly fiberblast growth
» factors like FGF7, and maybe beta catenin and wnt-protiens or wnt-mimetics
» like LiCl.
» These experiments are a great way to see if some of those can be shed or
» another thing or two has to be added for EDIHN hairs to grow on MPB scalp
» as opposed to donor-area scalp etc.
»
»
» The ball is rolling though…We had to wait
» three years for ICX to go from phase one to phase two while rolling our
» fingers.

I think one of the doctors in their team is at Harvard.

Damn, if they’re only doing this now its gonna be some time before this treatment is available for the paying public. Lets hope some of the home trialers here strike lucky because I dunno if I can wait another 3/4 years…

Did it say what kind of time frame we are talking about here? How long before it hits the market.

3-4 years? That depends how badly you want your hair back.

It has been said dozens of times in the last 3-6 months: Existing dermatological procedure + existing drugs. Nothing else.

If you don’t believe it will be derived from all existing stuff, then that’s your choice. I’m not here to change your mind.

But to come to that viewpoint, you had to want that viewpoint. The evidence has never said or implied anything to suggest any all-new substances or methods.

» Damn, if they’re only doing this now its gonna be some time before this
» treatment is available for the paying public. Lets hope some of the home
» trialers here strike lucky because I dunno if I can wait another 3/4
» years…

Our ancestors have-been dying bald for thousands of years; whereas we have a chance to see an actual cure within our lifetimes. Heck, 3/4 years would be a cakewalk if we knew unequivocally Follica had something commercially feasible.

Besides, I don’t understand the complaints coming from people right now. The first time most of us heard of Follica was in January when their funding was announced, and they did say trials would start this summer. Thus far, they’re staying true to their word. That’s a hell-of-allot more than we got from Aderans or InterCytex.

.

» » We must show in some way that we are eargerly waiting for this cure!!
» » Ofcourse they know that al baldies are dying to have this cure, but the
» » more we make them hear the better.
» »
» » Let’s call or send Harvard a mail all together and ask info about this
» » “trial”,
» »
» » Yooooo I am happyyyyyyyy
»
» sarcasm ?

Ofcourse not! I am just happy that is has started.

»
» Guys, its a Research Study NOT a trial…they’re probably looking at the
» phisiology of the bald scalp so they can better design formulate their
» technique.

Well said. All in all, its awesome that this company finally makes the step and gives up on useless research on mice.

» » I received this link from Follica, Inc., so it definitely is the real
» » deal. However, the website says the trial will “not treat baldness.”
» » WTF?!?
»
» I guess they mean you aren’t treating your hair loss ( propecia, minox,
» … ) while the trial is being done.

I was wrong, it just looks that they want to see the skin reaction to dermabrasion now, nothing more … so they say “not treat baldness”. For people believing in follica, I would recommend them to be very patient, it’s going to be long. On the other side, if they are doing the “real” dermabrasion, then it’s a major procedure with some risks, much more than microdermabrasion and medium peelings.

» The
» evidence has never said or implied anything to suggest any all-new
» substances or methods.

I guess so but the NBC Today Show spot with Matt Lauer had a different implication.

» Besides, I don’t understand the complaints coming from people right now.
» The first time most of us heard of Follica was in January when their
» funding was announced, and they did say trials would start this summer.
» Thus far, they’re staying true to their word. That’s a hell-of-allot more
» than we got from Aderans or InterCytex.
»

That’s a good point. I only wish they would do simultaneous testing on areas of the scalp that aren’t exposed to fibrosis to see how the efficacy is in the production of de novo hair in "good skin " areas…or maybe this is only to test the reaction of certain wounding depths… but then shouldn’t they do this on all area’s of the scalp?

» Did it say what kind of time frame we are talking about here? How long
» before it hits the market.
What would be good is that someone from HairSite that lives close to Boston attends the trials. One could then ask them on the spot the usual questions: how long until the “real” trials, what is the next step, is everything in the patent, what do they expect, estimated release date, etc. Maybe they will disclose some of the information.