» The comment that wounding does not necessarily involve dermabrasion
» (I believe that I recall that as well from one of the articles)
» seemed interesting as well. What could this possibly mean?
» Cell damage by bruising with point pressure? Some type of
» needle or lancet use? Flash freezing of a thin layer? Laser
» dermabrasion or just perhaps–induction of an internal disruption
» at a sub-surface level by focusing the laser in much the same
» way as radiation therapy is used without damaging other layers?
» Or even determining a way to signal the required activity without
» actual wounding?
I also read the article where is says wounding doesn’t necessarily involve dermabration.
IIRC in some of the mouse experiments they used a couple of diferent methods to disrupt the skin, from a felt wheel to incisional wounds.
Dr. Anderson who is on follicas team is an expert with medical lasers.
Taken from the kit patent:
The state of reepithelialization can be induced. Methods of inducing this state include the disruption of the subject’s skin at the location where the compounds of the invention are going to be administered. Disruption can be achieved through abrasion (e.g., the rubbing or wearing away of skin), or through any method that results in disturbing the intactness of the epidermis or epidermal layer including burning (e.g., by inducing a sunburn) or perforating the epidermis or epidermal -layer: The disruption can either result in partial or complete removal of the epidermal layer at the intended location.
The disruption of the epithelial layer can be accomplished, for example, through mechanical, chemical, electromagnetic, electrical, or magnetic means. Mechanical means can be achieved through the use of, for example, sandpaper, a felt wheel, ultrasound, supersonically accelerated mixture of saline and oxygen, tape-stripping, or peels.
Chemical means of disruption of the epidermis can be achieved, for example, using phenol, trichloracetic acid, or ascorbic acid.
Electromagnetic means of disruption of the epidermis can be achieved, for example, by the use of a laser capable of inducing trans-epithelial injury (e.g., a Fraxel laser, a CO2 laser, or an excimer laser). Disruption can also be achieved through, for example, the use of visible, infrared, ultraviolet, radio, or X-ray irradiation.
Electrical or magnetic means of disruption of the epidermis can be achieved, for example, through the application of an electrical current or through electroporation. Electric or magnetic means can also include the induction of an electric or a magnetic field. For example, an electrical current
can be induced in the skin by application of an alternating magnetic field. A radiofrequency power source can be coupled to a conducting element, and the currents that are induced will heat the skin, resulting in an alteration or disruption of the skin. In this embodiment, no external energy transfer is needed in order to cause a disruption
Any of the previously mentioned means of disruption can be used to induce for example, a burn, excision, or microdermabrasion.
Optionally, the skin, following the epidermal disruption, is not contacted for a period of time with any substance (e.g., ointment, a bandage, or a device) that is normally administered to an abrasion or wound to prevent infection.