1: FEBS Lett. 1993 Nov 15;334(2):161-4. Links
Inhibition of the epidermal growth factor receptor tyrosine kinase activity by leflunomide.Mattar T, Kochhar K, Bartlett R, Bremer EG, Finnegan A.
Department of Immunology, Johannes Gutenberg University, Mainz, Germany.
The active metabolite of leflunomide, A77 1726 inhibits the proliferation of a variety of mammalian cell lines in culture. Epidermal growth factor (EGF)-dependent proliferation is inhibited by A77 1726 at an effective dose of 30-40 microM. A77 1726 appears to directly inhibit the EGF receptor tyrosine-specific kinase activity both in intact cells and purified EGF receptors at the same effective dose. These data suggest that leflunomide inhibits cellular proliferation by the inhibition of tyrosine-specific kinase activities.
PMID: 8224241 [PubMed - indexed for MEDLINE]
obviouly it inhibits egf through an indirect route, through inhibition of tyrosine kinease activity…if you look around online, it apparently is pretty good for arthritis, unless much of what Ive read is corporate spam…