Treating hair loss with inhibitors of cholesterol synthesis

[HairSite_Admin]

Androgens are synthesized from cholesterol.

So is it possible to decrease the androgen levels by preventing cholesterol synthesis?

There are various inhibitors of cholesterol synthesis like ‘Statins’. Do they have any role to play in preventing hair loss?

[Bryan]

» Androgens are synthesized from cholesterol.
»
» So is it possible to decrease the androgen levels by preventing
» cholesterol synthesis?
»
» There are various inhibitors of cholesterol synthesis like ‘Statins’.
» Do they have any role to play in preventing hair loss?

Probably not. I do recall seeing a study in a medical journal a few years ago which tested the effect of a substance which is known to inhibit the conversion of cholesterol into pregnenolone (if I recall correctly). That conversion is the first biochemical step in the process of turning cholesterol into steroid hormones, including androgens. Unfortunately, the experiment had no effect on balding. Again, I hope I’m remembering the details correctly. It was quite a while ago that I read that.

.

[HairSite_Admin]

The study might have shown that it is not effective. But what is the reason??

Intake of Statins ---------------------> Low cholesterol
Low cholesterol --------------> Low androgens
Low androgens --------------------> Decreased hair loss

So intake of statins-------------------> no hair loss…

Is it not an attractive theory?

[Bryan]

» The study might have shown that it is not effective. But what is the
» reason??
»
» Intake of Statins ---------------------> Low cholesterol
» Low cholesterol --------------> Low androgens
» Low androgens --------------------> Decreased hair loss
»
» So intake of statins-------------------> no hair loss…
»
» Is it not an attractive theory?

I think the reason why it doesn’t work is fairly obvious: there are so many feedback loops in the body, especially when it comes to the production and regulation of androgens, you can’t just simply partially interefere with a far “upstream” factor like cholesterol synthesis and expect the effect to “trickle-down” into lower levels of androgens. Ahhhh, if only it were so simple!

.

[haroldo]

» The study might have shown that it is not effective. But what is the
» reason??
»
» Intake of Statins ---------------------> Low cholesterol
» Low cholesterol --------------> Low androgens
» Low androgens --------------------> Decreased hair loss
»
» So intake of statins-------------------> no hair loss…
»
» Is it not an attractive theory?

Statins are actually associated with hair loss. And inhibiting androgen production at such an early stage would be akin to castration if it did work. Oral Ketoconazole inhibits steroidogenesis if that is of interest. As does cyproterone acetate and I believe spironolacton (though perhaps only in the adrenal glands).
hh

[eddy07]

» Androgens are synthesized from cholesterol.
»
» So is it possible to decrease the androgen levels by preventing cholesterol
» synthesis?
»
» There are various inhibitors of cholesterol synthesis like ‘Statins’. Do
» they have any role to play in preventing hair loss?

I like home remedies to prevent or to treat hair loss problem.Grind lime seeds and black pepper in equal quantities in a small amount of water and apply this on the scalp daily. This is one of the good home remedies for hair loss.

Washing the hair with a paste of cooked black gram dal and fenugreek lengthens the hair. This is very useful hair loss cure.A fine paste made from pigeon pea or red gram can also be applied for treatment of baldness and hair loss. This is one of the effective home remedies for baldness.

[Cole_Kutz]

» » The study might have shown that it is not effective. But what is the
» » reason??
» »
» » Intake of Statins ---------------------> Low cholesterol
» » Low cholesterol --------------> Low androgens
» » Low androgens --------------------> Decreased hair loss
» »
» » So intake of statins-------------------> no hair loss…
» »
» » Is it not an attractive theory?
»
» I think the reason why it doesn’t work is fairly obvious: there are so
» many feedback loops in the body, especially when it comes to the production
» and regulation of androgens, you can’t just simply partially interefere
» with a far “upstream” factor like cholesterol synthesis and expect the
» effect to “trickle-down” into lower levels of androgens. Ahhhh, if only it
» were so simple!
»
»

Taking high and consistent amounts of Omega 3 & 6 not only helps lower cholesterol but also thickens hair and helps with growth…why do you think that is???

[Bryan]

» Taking high and consistent amounts of Omega 3 & 6 not only helps
» lower cholesterol but also thickens hair and helps with growth…
» why do you think that is???

How do you know it thickens hair and helps with growth? Give me a medical reference or citation in support of that claim.

[Gemsonline]

» Androgens are synthesized from cholesterol.
»
» So is it possible to decrease the androgen levels by preventing cholesterol
» synthesis?
»
» There are various inhibitors of cholesterol synthesis like ‘Statins’. Do
» they have any role to play in preventing hair loss?

Awesome post! please keep up the great work i would love to hear more like this.

[vimax]

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[Ahab]

» Androgens are synthesized from cholesterol.
»
» So is it possible to decrease the androgen levels by preventing cholesterol
» synthesis?
»
» There are various inhibitors of cholesterol synthesis like ‘Statins’. Do
» they have any role to play in preventing hair loss?

I recall that male pattern baldness and heart disease were both rare in Japan before Japan adopted the Western diet.

Since adopting the Western diet, the incidence of baldness and heart disease in Japan have both risen dramatically.

Before adopting the Western diet, people in Japan ate mostly vegetables.

So who knows–maybe there is a connection between cholesterol levels and baldness.