Here is the background. I do not suffer from hairloss, but acne. It is not severe by any means, just resistant to all other forms of treatment. The only thing that has worked 100% in the past is Accutane. I believe that in my case, Accutane was the only drug to effectively control excess sebum. After spending a decent amount of time researching this problem, I came to the conclusion that the best way to treat this would be some sort of topical antiandrogen or 5ar inhibitor. Currently, there are no prescription medicines which address acne in this method. Oral antiandrogens are very effective such as spiro or birth control, but obviously come with tons of side effects and no man should ever take these medications orally. I spoke with my dermatologists about the matter, and he agreed that this would be a logical method of attacking acne. I first looked at ru54881 which ideally would be the best substance out there, since it binds to the AR receptor and isn’t meant to be absorbed systemically. But after I figured out how difficult it is to obtain, its questionable purity and its storage stability, I realized that this wouldn’t be a practical substance to test. And if it did work, it would be a pain to keep treatment going long term for reasons mentioned above. Then I came across avodart. As you all know, avodart is a potent dht inhibitor which target both 1 and 2 isozymes. People have also reported success with a topical preparation for treating hairloss. Dutasteride has the ability for penetrating the skin, which makes it a perfect drug to test for excess sebum caused by too much dht (presumably) in the skin. Some people have claimed to have reduced oil when the medication was taken orally, and a few people have mentioned that spreading the oil topically has worked as well. I would like to put this idea to the test.
One problem with putting the avodart oil straight on the face is if it does work there is probably a good amount of the drug being absorbed systemically. I propose making a dilute solution in order to reduce systemic absoprtion. It would consist of dutasteride, alcohol, water and propylene glycol as a carrier solution. I would try to formulate it in a similar manner to the one used for ru54881. However, if anyone has any input on making an effective carrier I am interested in your opinion. Since this would be mostly applied to the face, I would try to use as little alcohol as possible. Just enough to thoroughly dissolve the contents of the avodart.Then add water to dilute it to the test concentration and enough ppg just to get a light, gel consistency. I haven’t figured out the exact measurements of the first trial yet. I was thinking maybe 2 avodart pills in a 50 ml solution. I would estimate that I would be applying about 2 ml of solution a day so this should last me about a month. If successful, I would continue to tweak the solution so I could figure out what would be the lowest effective dosage. I would like anyone’s feedback on this proposed experiment. Recommendations and criticisms are welcome.