Hi Spanish Dude,
You are one of the most thoughtful and skeptical people here, you look beneath the conventional explanations for the real science behind things…
Recently you advanced the ‘hot zones’ theory, regarding why cell therapies like Intercytex TRC seem to work only sporadically or spottily. Correct me if i’m wrong, but your theory seems to be that each individual’s scalp has different zones, some of which are more amenable to cell injections, while other areas are resistant. You indicate that this phenomenon is responsible for the generally variable and poor results we see in most cell based hair regeneration trials.
I understand your theory, but i have a different theory which i would like you to consider:
I think that the problem is really that when cell injections are performed, as soon as the cells enter the skin, they immediately start moving away from each other, because there is nothing really that holds them in close proximity to each other.
The cells are really entering an aqueous environment, which is the intercellular spaces between skin cells in the dermis. So even if the cells are kept together within the syringe, as soon as they are ejected out of the syringe, they enter an environment where they quickly drift apart.
But the DP cells must be very close together, exceedingly tightly packed, in order to have a chance at successfully forming a hair-follicle bud.
Since with every injection, the cells will drift away from each other at slightly different rates (statistically this will be true), a certain percentage of injections may be successful, but a certain percentage won’t.
The Aderans “scaffold” idea is a way to prevent this from happening, because it keeps the injected cells in close proximity, therefore increasing their chances of forming a proto-follicle.
I believe that this is the fundamental problem that all HM experimenters, from Gho onward, have experienced in their work… although they may not have known or understood it. They certainly did not articulate it, and didn’t tell any of us it was the problem.
The problem is therefore more “mechanical” than biological. It is based on simple “Brownian motion”, the tendency of particles of any size, floating in a liquid environment, to eventually move apart from each other and spread in a random pattern.
I think that this theory explains why HM seems to have generally low, and unreliable “yields”. The yield being the percentage of successful divided by all the injections, or:
Yield = number of successful injections / total number of injections
The real, longstanding problem with ALL the HM experiments and trials we’ve seen is that, while it seems to work sometimes, it is generally neither reliable nor predictable.
I believe that my theory explains this physical fact.
This explanation does not mean that Aderans’ scaffolds will be a miracle solution that will resolve this problem completely and form perfect hair follicles all the time. However, it does indicate that the Aderans approach may be better, and has the potential to leverage HM into a more reliable clinical procedure.
What do you think?