Irreversibility of hair follicle damage after 30 months of Androgenetic Alopecia AGA
Konstantinova N, Korotkii N.G, Sharova N, Barhunova E,
Moscow Medical University
"… 11 patients with AGA longer than 3 years had perifollicular fibrosis - collagen fibers were compact and formed a small scar like formation around each anagen hair follicle. 2 patients (18 month of AGA and 20 month of AGA) did not have these hair follicle changes. 2 patients (30 and 36 month of AGA)were found to have some but not so severe collagen fiber changes.
…we showed a correlation between length of AGA and severity/thickness of perifollicular fibrosis. The result of this study is that any treatment of AGA is recommended to start earlier than 30 months from first signs of AGA. This should prevent irreversible collagen changes associated with “fibrotic incapsulation” of most anagen hair follicles in involved areas, which usually leads to loss of normal blood supply, innervation, and subsequent miniaturization and prevention of hair from normal cycling."