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Study: irreversibility of hair follicle damage after 30 mos


#1

Irreversibility of hair follicle damage after 30 months of Androgenetic Alopecia AGA
Konstantinova N, Korotkii N.G, Sharova N, Barhunova E,
Moscow Medical University

"… 11 patients with AGA longer than 3 years had perifollicular fibrosis - collagen fibers were compact and formed a small scar like formation around each anagen hair follicle. 2 patients (18 month of AGA and 20 month of AGA) did not have these hair follicle changes. 2 patients (30 and 36 month of AGA)were found to have some but not so severe collagen fiber changes.

…we showed a correlation between length of AGA and severity/thickness of perifollicular fibrosis. The result of this study is that any treatment of AGA is recommended to start earlier than 30 months from first signs of AGA. This should prevent irreversible collagen changes associated with “fibrotic incapsulation” of most anagen hair follicles in involved areas, which usually leads to loss of normal blood supply, innervation, and subsequent miniaturization and prevention of hair from normal cycling."


#2

how would this study account for people who have been losing hair for even a decade, and respond so wonderously to drugs like propecia? this study seems at odds with reality.


#3

» Irreversibility of hair follicle damage after 30 months of Androgenetic
» Alopecia AGA

» Konstantinova N, Korotkii N.G, Sharova N, Barhunova E,
» Moscow Medical University
»
» “… 11 patients with AGA longer than 3 years had perifollicular fibrosis
» - collagen fibers were compact and formed a small scar like formation
» around each anagen hair follicle. 2 patients (18 month of AGA and 20 month
» of AGA) did not have these hair follicle changes. 2 patients (30 and 36
» month of AGA)were found to have some but not so severe collagen fiber
» changes.
»
» …we showed a correlation between length of AGA and severity/thickness of
» perifollicular fibrosis. The result of this study is that any treatment of
» AGA is recommended to start earlier than 30 months from first signs of
» AGA. This should prevent irreversible collagen changes associated with
» “fibrotic incapsulation” of most anagen hair follicles in involved areas,
» which usually leads to loss of normal blood supply, innervation, and
» subsequent miniaturization and prevention of hair from normal cycling.”

I used to agree with this, but after seeing pics of gc1961 and all the regrowth he got with Nizoral in that 10 year old bald spot, i tend to think that the hair follicles are not irreversably damaged after 30 months


#4

I don’t believe this to be the case. NONE of us would have a chance of growing back ANY hair if this were the case. Since it is said that up to 50% of one’s hair can be lost before noticing signs of AGA, this would imply that it is very unlikely for ANYONE to regrow any of their lost hair. This has been contradicted time and again by users of minoxidil, propecia, vitamins, etc., etc. This simply cannot be the norm. I think that the study is flawed.


#5

» I don’t believe this to be the case. NONE of us would have a chance of
» growing back ANY hair if this were the case. Since it is said that up to
» 50% of one’s hair can be lost before noticing signs of AGA, this would
» imply that it is very unlikely for ANYONE to regrow any of their lost
» hair. This has been contradicted time and again by users of minoxidil,
» propecia, vitamins, etc., etc. This simply cannot be the norm. I think
» that the study is flawed.

I have tremendous thickening and regrowth in my thin areas and zero regrowth in my bald spot with vitamins and dht blockers
thus I came to the conclusion that regrowth in bald areas is next to impossible
however gc1961 pics plus the japanese study pics I posted with nizoral lead me to the conclusion that regrowth is possible

im about 10 day into nizoral cream daily, so hopefully i get something happening up there, would be a nice morale booster


#6

» » I don’t believe this to be the case. NONE of us would have a chance of
» » growing back ANY hair if this were the case. Since it is said that up
» to
» » 50% of one’s hair can be lost before noticing signs of AGA, this would
» » imply that it is very unlikely for ANYONE to regrow any of their lost
» » hair. This has been contradicted time and again by users of minoxidil,
» » propecia, vitamins, etc., etc. This simply cannot be the norm. I think
» » that the study is flawed.
»
» I have tremendous thickening and regrowth in my thin areas and zero
» regrowth in my bald spot with vitamins and dht blockers
» thus I came to the conclusion that regrowth in bald areas is next to
» impossible
» however gc1961 pics plus the japanese study pics I posted with nizoral
» lead me to the conclusion that regrowth is possible

I have always held the view that hair follicles are extremely resilient.

Regards
Pete


#7

Please forgive me if I am wrong, but I thought that this website was intended to provide HOPE to those suffering from MPB. Posting this study is the very antithesis of hope.


#8

» Irreversibility of hair follicle damage after 30 months of Androgenetic
» Alopecia AGA

» Konstantinova N, Korotkii N.G, Sharova N, Barhunova E,
» Moscow Medical University
»
» “… 11 patients with AGA longer than 3 years had perifollicular fibrosis
» - collagen fibers were compact and formed a small scar like formation
» around each anagen hair follicle. 2 patients (18 month of AGA and 20 month
» of AGA) did not have these hair follicle changes. 2 patients (30 and 36
» month of AGA)were found to have some but not so severe collagen fiber
» changes.
»
» …we showed a correlation between length of AGA and severity/thickness of
» perifollicular fibrosis. The result of this study is that any treatment of
» AGA is recommended to start earlier than 30 months from first signs of
» AGA. This should prevent irreversible collagen changes associated with
» “fibrotic incapsulation” of most anagen hair follicles in involved areas,
» which usually leads to loss of normal blood supply, innervation, and
» subsequent miniaturization and prevention of hair from normal cycling.”

Wouldn’t this make rejuvenation a near impossibility in the HM protocol?