Some thoughts on PGD2 fighting

Stem cell; cell based hair therapy
1

We may be looking at a revolutionary way of treating MPB. But I think it’s more likely that we are just looking at what amounts to a better anti-androgen. Fighting PDG2 is a more direct method than fighting androgens but I think it may not have any higher ultimate capabilities.

Alecbaldone & a few others are reporting good success with it and I believe them. But everyone seems to start Minox (and sometimes Fin or Dut) at the same time. Can’t blame them, but there goes the validity of their PGD2 results. I have yet to see any cases of regrowth from these PGD2 efforts that falls outside the normal range of the other drugs that the person added to their regimen at the same time.

PDG2 chemical + Minox = Minox-like regrowth?

Hmm . . . not exactly a game changing discovery.

Furthermore, do we ever find an MPB treatment that causes a totally uniform reaction? Fin & Minox are very reliable in the big picture and yet there are always some users who regrow outstanding amounts or never even slow down their loss. And then there is Keto shampoo – some say they do better than Minox with it (and there is data to support the idea), while others get nothing or even complain of irritation & loss. My point is that the difference in results between different users may be due to the people as much as anything.

The Iron Dragon stuff is based on a couple of non-exotic existing chemicals so it’s probably real. There may be absorption problems but I suspect the users are getting at least some of the intended effect from it.

I think we are seeing what PGD2 fighting can do (or at least some of it) and we’re getting disappointed because we expected too much. If we had gone into this only hoping it would slow/stop loss then we might be pretty happy with it right now.

2

In Dr. Cots pgd2 study, they showed that Fibroblast growth factor-5 which is known to inhibit hair growth induced catagen as well as pgd2 in one of the diagrams. My question is what makes blocking Pgd2 more important than blocking FGF-5? im starting to think that the pgd2 discovery was just another way for Dr Cots to get more funding.

3

» We may be looking at a revolutionary way of treating MPB. But I think it’s
» more likely that we are just looking at what amounts to a better
» anti-androgen. Fighting PDG2 is a more direct method than fighting
» androgens but I think it may not have any higher ultimate capabilities.
»
» Alecbaldone & a few others are reporting good success with it and I believe
» them. But everyone seems to start Minox (and sometimes Fin or Dut) at the
» same time. Can’t blame them, but there goes the validity of their PGD2
» results. I have yet to see any cases of regrowth from these PGD2 efforts
» that falls outside the normal range of the other drugs that the person
» added to their regimen at the same time.
»
»
» PDG2 chemical + Minox = Minox-like regrowth?
»
» Hmm . . . not exactly a game changing discovery.
»
»
»
» Furthermore, do we ever find an MPB treatment that causes a totally uniform
» reaction? Fin & Minox are very reliable in the big picture and yet there
» are always some users who regrow outstanding amounts or never even slow
» down their loss. And then there is Keto shampoo – some say they do better
» than Minox with it (and there is data to support the idea), while others
» get nothing or even complain of irritation & loss. My point is that the
» difference in results between different users may be due to the people as
» much as anything.
»
» The Iron Dragon stuff is based on a couple of non-exotic existing chemicals
» so it’s probably real. There may be absorption problems but I suspect the
» users are getting at least some of the intended effect from it.
»
» I think we are seeing what PGD2 fighting can do (or at least some of it)
» and we’re getting disappointed because we expected too much. If we had gone
» into this only hoping it would slow/stop loss then we might be pretty happy
» with it right now.

Well said Cal. I will add this… I started by using only the Iron-dragon PDG2 inhibitor for the first 6 weeks and it works to stop hair loss. my hair loss stopped in 2 days, literally. Nothing in the past 20 years, dut, fin, minox, emu oil, vitamin x, nothing stoppped my hair loss except the ID product. In the past when I did minox alone I got 0 results, didn’t grow anything or didnt slow hair loss, used it for about 1 year. Secondly when I tried Duteresteride 10 years ago, it immediately grew tons of noticeable vellous hairs that quickly fell out and never returned and didnt slow hair loss. Dut almost worked, in my opinion. Thirdly, fin did absolutely nothing for me but make my semen clumpy and low libido. Ok so first 6 weeks of Iron Dragon my scalp felt tighter, sunburned, and itched. About week 4 skin was peeling off so at night I would add neosporin or hydrocortisone for a few nights and it cleared up my flaking and also head and shoulders ahampoo. At week 6 I added minox and quickly noticed vellous hair growing along temples, longer than normal peach fuzz but still white and thin. week 8 I added Dut and now Im at week 15 with a ton of vellous growing very slowly and a few randon dark hair growing in bald areas. the dark hairs growing are a bit smaller in diameter than a regular normal healthy growing hair, but none the less something growing. With all that being said, yesterday “hairlesswonder” posted pic of his scalp on the ID and minox and he has a little bit more regrowth than me. I only have a camera phone and Im going to try and post some pics of my head, but hairlesswonder is regrowing hair and is skilled picture taker to camture it. Most f my regrowth is only visable in magnifying mirror. The point of my long speech is that this ID product works. If it doesnt regrow a complete head of hair it will at least stop hair loss and provide SOME regrowth. This tells me that we are EXTREMELY close to developing a topical cure, very very close. As far as Absorption goes I assume it is getting into my scalp as it peeled a layer of skin off of my scalp at wek 4 from the change to a drier scalp. I understand everyone on this forum is skeptical since we’ve been dumped so many times, however there are several of us credible posters on here with the same story. Hair loss stopped and starting some regrowth. I am 44 yr old man so I assume you younger guys will have more aggressive and faster regrowth. I highly recommend to anyone to try the ID product, it is only $75 for 2 months supply and it is much cheaper than trying to make your own. Look at the pic of hairlesswonder and tell me this doesnt work. Alec

4

Alec, I would like to mention the pic is from my phone camera as well. Even my wife is starting to notice a difference. Pretty exciting stuff over here.

HW

5

my pictures get blurry if I hold camera too close to scalp. I have a 2008 Blackberry!! My regrowth area looks exactly like yours. The diameter off my new hairs is smaller at this point. 4 months.

6

I’ve just posted this same thing on another forum, but there seems to be all this revisionism going on about this thing.

The theory of inhibiting PGD2, the one we extrapolated from the studies anyway, was the idea that PGD2 was the final link in the chain that is inhibiting the growth of your hair.

The fundamental difference is supposed to be that once this inhibitor is removed hair will grow to full terminal length, just like non balding hair. And this in theory could happen within one cycle of the hair.

We know hitting the cascade at the dht end will halt hair loss(citation needed), but the promise of PGD2 inhibition is regrowth, massive, potentially full regrowth.

I’m not saying it will work, I’m not saying it should have. I’m just saying that theoretically, PDG2 inhibition has far more potential than DHT inhibition. It has the potential to be the silver bullet.

If a study is released tomorrow showing that after all it has no real effect when used in vivo on humans, then ok. But there is a rational basis for the optimism.

7

sux we wont be able to buy this from IronDragon anymore, we need to find a new source because it works.