I haven’t posted here for years because my herbal regimen has more or less stopped my hair loss (when I don’t drink too much), but I’ve followed the recent threads about DIY Follica treatments with interest. One barrier to the DIY approach seems to be access to often expensive prescription drugs for EGFR inhibition, so I thought I would look for alternatives. A search for “EGFR Inhibitor herbal” turned up this article: http://www.cicta.ca/journal/review_article.php.
Here are the relevant parts:
Sea Cucumber Extract contains the active ingredient Philinopside A, which has been shown through various studies to inhibit four different RTKs: vascular endothelial growth factor receptor (VEGFR), epidermal growth factor receptor (EGFR), platelet-derived growth factor receptor (PDGFR) and fibroblast growth factor receptor (FGFR)6,7.
Tong Y, Zhang X, Tian F, Yi Y, Xu Q, Li L, et al. Philinopside A, a novel marine-derived compound possessing dual anti-angiogenic and anti-tumor effects. Int J Cancer. 2005; 114:843-53.
Tian F, Zhang X, Tong Y, Yi Y, Zhang S, Li L, et al. PE, a New sulfated Saponin from Sea Cucumber, Exhibits Anti-Angiogenic and Anti-Tumor Activities in vitro and In Vivo.Cancer Biol Ther. 2005 Aug; 4(8):874-882.
I’m curious about whether this would make a viable substitute for commercial drugs.