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Piroctone Olamine Shampoos


#1

I have now tried three different shampoos containing PO (none of which list the concentration of PO). Here is my assessment of these shampoos:

  1. Regenerator from Calosol: This is an over-priced shampoo that comes in a very small bottle (100 ml). This shampoo made my hair look lifeless as if it were covered with a thin coating of oil. It caused some irritation and I stopped using it after two attempts.

  2. SeS Kavel Anti-Dandruff Shampoo: This is also an overpriced shampoo that gave results similar to the Calosol shampoo. It smells like cheap perfume and is a waste of money.

  3. Ginger Scalp Care Shampoo from The Body Shop: This one is a keeper. It has a slight, pleasant scent and leaves my scalp feeling very clean and “healthy”. It makes my hair look and feel much thicker and is a decent shampoo for the price. I will order it again.

Anyone have any similar experiences?


#2

» I have now tried three different shampoos containing PO (none of which list
» the concentration of PO). Here is my assessment of these shampoos:
»
» 1. Regenerator from Calosol: This is an over-priced shampoo that
» comes in a very small bottle (100 ml). This shampoo made my hair look
» lifeless as if it were covered with a thin coating of oil. It caused some
» irritation and I stopped using it after two attempts.
»
» 2. SeS Kavel Anti-Dandruff Shampoo: This is also an overpriced
» shampoo that gave results similar to the Calosol shampoo. It smells like
» cheap perfume and is a waste of money.
»
» 3. Ginger Scalp Care Shampoo from The Body Shop: This one is a
» keeper. It has a slight, pleasant scent and leaves my scalp feeling very
» clean and “healthy”. It makes my hair look and feel much thicker and is a
» decent shampoo for the price. I will order it again.
»
» Anyone have any similar experiences?

JT,

I brought the Body Shop shampoo, but stopped using it.

My7 main reason was that apart from the study that showed it was effective, I couldn’r find any research on PO or how it was effective againts hair loss. This is different from Nizoral (Keto) which has a lot of documented research.


#3

gc1961:

I am going by heresay, basically. I was intrigued by the fact that Calosol started to sell PO shampoo. Calosol, by all accounts, is a company dedicated to helping those with all sorts of hair loss problems, namely Alopecia Areata. They seem genuinely eager to help those afflicted and do not seem like a company hell-bent on making tons of money.

It was kind of funny - I did a search on Piroctone Olamine and found a chemicals distributor who listed the possible uses of PO to include “a treatment for hair loss”. This was listed last in a list of possible uses. I had never even heard of it being touted as a hair loss treatment before reading it on Hairsite.

Aside from its possible usefulness as a hair loss treatment, it is a good shampoo that really seems to reduce itching and irritation. If it helps with hair loss, so much the better.

I still use Nizoral once or twice a week.


#4

» My7 main reason was that apart from the study that showed it was
» effective, I couldn’r find any research on PO or how it was effective
» againts hair loss. This is different from Nizoral (Keto) which has a lot
» of documented research.

Pete posted this regarding PO:

Nudging hair shedding by antidandruff shampoos. A comparison of 1% ketoconazole, 1% piroctone olamine and 1% zinc pyrithione formulations.

Original Articles

International Journal of Cosmetic Science. 24(5):249-256, October 2002.
Pierard-Franchimont, C.; Goffin, V.; Henry, F.; Uhoda, I.; Braham, C.; Pierard, G. E.
Abstract:
Synopsis: Hair shedding and hair thinning have been reported to be affected by dandruff and seborrhoeic dermatitis. The present study was conducted in 150 men presenting with telogen effluvium related to androgenic alopecia associated with dandruff. They were randomly allocated to three groups receiving each one of the three shampoos in the market containing either 1% ketoconazole (KTZ), 1% piroctone olamine (PTO) or 1% zinc pyrithione (ZPT). Shampoos had to be used 2-3 times a week for 6 months. Hair shedding during shampoo was evaluated semiquantitatively. Hair density on the vertex was evaluated on photographs using a Dermaphot. Trichograms were used for determining the anagen hair percentage and the mean proximal hair shaft diameter using computerized image analysis. The sebum excretion rate (SER, [mu]g cm-2 h-1) was also measured using a Sebumeter®.

The three treatments cleared pruritus and dandruff rapidly. At end point, hair density was unchanged, although hair shedding was decreased (KTZ: -17.3%, PTO: -16.5%, ZPT: -10.1%) and the anagen hair percentage was increased (KTZ: 4.9%, PTO: 7.9%, ZPT: 6.8%). The effect on the mean hair shaft diameter was contrasted between the three groups of volunteers (KTZ: 5.4%, PTO: 7.7%, ZPT: -2.2%). In conclusion, telogen effluvium was controlled by KTZ, PTO and ZPT shampoos at 1% concentration. In addition, KTZ and PTO increased the mean hair shaft thickness while discretely decreasing the sebum output at the skin surface.

© 2002 Blackwell Science Ltd.


#5

» » My7 main reason was that apart from the study that showed it was
» » effective, I couldn’r find any research on PO or how it was effective
» » againts hair loss. This is different from Nizoral (Keto) which has a
» lot
» » of documented research.
»
» Pete posted this regarding PO:
»
» Nudging hair shedding by antidandruff shampoos. A comparison of 1%
» ketoconazole, 1% piroctone olamine and 1% zinc pyrithione formulations.
»
» Original Articles
»
» International Journal of Cosmetic Science. 24(5):249-256, October 2002.
» Pierard-Franchimont, C.; Goffin, V.; Henry, F.; Uhoda, I.; Braham, C.;
» Pierard, G. E.
» Abstract:
» Synopsis: Hair shedding and hair thinning have been reported to be
» affected by dandruff and seborrhoeic dermatitis. The present study was
» conducted in 150 men presenting with telogen effluvium related to
» androgenic alopecia associated with dandruff. They were randomly allocated
» to three groups receiving each one of the three shampoos in the market
» containing either 1% ketoconazole (KTZ), 1% piroctone olamine (PTO) or 1%
» zinc pyrithione (ZPT). Shampoos had to be used 2-3 times a week for 6
» months. Hair shedding during shampoo was evaluated semiquantitatively.
» Hair density on the vertex was evaluated on photographs using a Dermaphot.
» Trichograms were used for determining the anagen hair percentage and the
» mean proximal hair shaft diameter using computerized image analysis. The
» sebum excretion rate (SER, [mu]g cm-2 h-1) was also measured using a
» Sebumeter®.
»
» The three treatments cleared pruritus and dandruff rapidly. At end point,
» hair density was unchanged, although hair shedding was decreased (KTZ:
» -17.3%, PTO: -16.5%, ZPT: -10.1%) and the anagen hair percentage was
» increased (KTZ: 4.9%, PTO: 7.9%, ZPT: 6.8%). The effect on the mean hair
» shaft diameter was contrasted between the three groups of volunteers (KTZ:
» 5.4%, PTO: 7.7%, ZPT: -2.2%). In conclusion, telogen effluvium was
» controlled by KTZ, PTO and ZPT shampoos at 1% concentration. In addition,
» KTZ and PTO increased the mean hair shaft thickness while discretely
» decreasing the sebum output at the skin surface.
»
» © 2002 Blackwell Science Ltd.

Chia, I think everyone using PO is doing so because of this comparison. The problem is I can’t find anything (at all) that suggests why it is working; of course we don’t know why Minox works either, but at least it has been researched.

This is very different for Nizoral, which has been pretty heavily researched bc it may also be useful in fighting cancer and organ transplant rejection; in addition to its intented use as an antifungal.


#6

» gc1961:
»
» I am going by heresay, basically. I was intrigued by the fact that Calosol
» started to sell PO shampoo. Calosol, by all accounts, is a company
» dedicated to helping those with all sorts of hair loss problems, namely
» Alopecia Areata. They seem genuinely eager to help those afflicted and do
» not seem like a company hell-bent on making tons of money.
»
» It was kind of funny - I did a search on Piroctone Olamine and found a
» chemicals distributor who listed the possible uses of PO to include “a
» treatment for hair loss”. This was listed last in a list of possible uses.
» I had never even heard of it being touted as a hair loss treatment before
» reading it on Hairsite.
»
» Aside from its possible usefulness as a hair loss treatment, it is a
» good shampoo that really seems to reduce itching and irritation. If it
» helps with hair loss, so much the better.
»
» I still use Nizoral once or twice a week.

Im glad youve found a shampoo that helps out of the “bunch” youve tried.

Piroctone Olamine has many modes of action and those modes of action combined should help to reduce inflammation or the " Immunal Response" in male hairloss.

Regards
Pete


#7

» » gc1961:
» »
» » I am going by heresay, basically. I was intrigued by the fact that
» Calosol
» » started to sell PO shampoo. Calosol, by all accounts, is a company
» » dedicated to helping those with all sorts of hair loss problems, namely
» » Alopecia Areata. They seem genuinely eager to help those afflicted and
» do
» » not seem like a company hell-bent on making tons of money.
» »
» » It was kind of funny - I did a search on Piroctone Olamine and found a
» » chemicals distributor who listed the possible uses of PO to include “a
» » treatment for hair loss”. This was listed last in a list of possible
» uses.
» » I had never even heard of it being touted as a hair loss treatment
» before
» » reading it on Hairsite.
» »
» » Aside from its possible usefulness as a hair loss treatment, it is a
» » good shampoo that really seems to reduce itching and irritation. If it
» » helps with hair loss, so much the better.
» »
» » I still use Nizoral once or twice a week.
»
»
»
»
»
» Im glad youve found a shampoo that helps out of the “bunch” youve tried.
»
» Piroctone Olamine has many modes of action and those modes of action
» combined should help to reduce inflammation or the " Immunal Response" in
» male hairloss.
»
»
»
» Regards
» Pete

Pete, can you please point us tp the research that supports the PO model of action; I can’t find it anywhere. All I can see is the study that says it works.


#8

» » » gc1961:
» » »
» » » I am going by heresay, basically. I was intrigued by the fact that
» » Calosol
» » » started to sell PO shampoo. Calosol, by all accounts, is a company
» » » dedicated to helping those with all sorts of hair loss problems,
» namely
» » » Alopecia Areata. They seem genuinely eager to help those afflicted
» and
» » do
» » » not seem like a company hell-bent on making tons of money.
» » »
» » » It was kind of funny - I did a search on Piroctone Olamine and found
» a
» » » chemicals distributor who listed the possible uses of PO to include
» “a
» » » treatment for hair loss”. This was listed last in a list of possible
» » uses.
» » » I had never even heard of it being touted as a hair loss treatment
» » before
» » » reading it on Hairsite.
» » »
» » » Aside from its possible usefulness as a hair loss treatment, it is
» a
» » » good shampoo that really seems to reduce itching and irritation. If
» it
» » » helps with hair loss, so much the better.
» » »
» » » I still use Nizoral once or twice a week.
» »
» »
» »
» »
» »
» » Im glad youve found a shampoo that helps out of the “bunch” youve
» tried.
» »
» » Piroctone Olamine has many modes of action and those modes of action
» » combined should help to reduce inflammation or the " Immunal Response"
» in
» » male hairloss.
» »
» »
» »
» » Regards
» » Pete
»
» Pete, can you please point us tp the research that supports the PO model
» of action; I can’t find it anywhere. All I can see is the study that says
» it works.

This was the first ever reference i found to it many many years ago.

http://drmirkin.com/archive/6943.html

Its said to have anti-oxidant, antibacterial, anti-inflammatory properties.

Regards
Pete


#9

Interesting. I wonder how much of this effect can be attributed to PO and how much to triclosan. Maybe I should shampoo with both the PO shampoo and Dial Anti-bacterial Hand Soap (which contains triclosan as the anti-bacterial agent):slight_smile:


#10

A Piroctone Olamine shampoo that I’m using and liking is Phyto Phytosylic anti-dandruff shampoo. I found it the cheapest with free shipping at (sounds gay I know) dermagirl.com.
http://www.dermagirl.com/phphsh67floz.html

I’m also using giovanni organic tea tree oil conditioner. It doesn’t contain PO, but it contains lots of tea tree oil and peppermint. It seems to get the blood flow going. I love the feeling. Very similar to menthol, but gentler.

Perry


#11

Perry:

I could swear that I have seen this shampoo in Whole Foods - the packaging looks very familiar. I am going to have to give it a try. It sounds like a good shampoo.