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PDGF, pro-anagen ally?


#1

PDGF isoforms induce and maintain anagen phase of murine hair follicles

Background : It is known that platelet-derived growth factor (PDGF) receptors are expressed in hair follicle (HF) epithelium. Objectives : The aim of the present study was to clarify the effects of PDGF-AA and -BB on the cyclic growth of HFs. Methods : PDGF-AA or -BB was injected into the dorsal skin of C3H mice during the second telogen phase once daily for five consecutive days, or PDGF-AA or -BB dissolved in hyaluronic acid was injected only once. In order to confirm the effects of different PDGF isoforms, anti-PDGF-AA antibody or anti-PDGF-BB antibody was injected just after each injection of PDGF-AA or -BB. In addition, anti-PDGF antibodies were injected into the skin of C3H mice during the second anagen phase once daily for 5 days. We studied expression of signaling molecules in the skin where anagen phase had been induced by PDGF injection by real-time RT-PCR. Results : Both PDGF-AA and -BB injection experiments immediately induced the anagen phase of the hair growth cycle at the injection sites. The induction of anagen was interfered by anti-PDGF antibody treatment. Real-time RT-PCR using extracted RNA from the PDGF injected sites of skin samples showed upregulated expression of HF differentiation-related key signaling molecules, Sonic hedgehog (Shh), Lef-1 and Wnt5a. Conclusions : These results indicate that both PDGF-AA and -BB are involved in the induction and maintenance of the anagen phase in the mouse hair cycle. Local application of PDGF-AA and -BB might therefore prove to be an effective treatment option for alopecia associated with early catagen induction and elongated telogen phase

I guess thrombin promotes/induces PDGF expression. I saw at least one report of bovine thrombin being used topically as a wound treatment and know of at least one vendor offering free samples of it… that is of course provided that your James Bond skills are up to par. What you know about that Consolidated Research Systems, LLC… hahahah