» On what day did your skin start peeling after the multi-layered peel?
» I’m a bit vague about when to deem it ‘Day One’ for purposes of
» application of the topicals. I’ve previously began applying topicals on
» about Day 3 or 4 post wounding after the skin shows signs of epithelization
» and maybe a little peeling.
» I need to make a solid decision on when to apply the topicals and when to
» cease wnt inhibition and begin boosting.
» For instance, I could orally inhibit wnt with quercetin and curcumin right
» from Day 1. This will also supplement the EGF inhibition.
» Then on Day 4, I could begin applying the topical gefit and also a topical
» wnt inhibitor made from quercetin and curcumin.
» On Day 10 I could cease the oral and topical wnt inhibition and just
» continue with the gefit until about Day 18.
»
» The only thing I’m worried about is the possibility of the embryonic
» window being unique to the individual and also possibly influenced by exact
» depth of wound. These variables could possibly displace the window to an
» earlier or later point. What do you think?
»
» P.S. I’m not asking because I’ve received your topical. I don’t expect to
» get that before the New Year due to the increased volume of post over the
» festive period.
Sorry, I just came back from vacation and I didn’t have access to a computer. I started getfitnib 24 hours after last wounding and I sterted to peel around the 4th day after wounding. I’m still clueless about the window issue and I didn’t inhibit wnt at all.
» Sorry, I just came back from vacation and I didn’t have access to a
» computer. I started getfitnib 24 hours after last wounding and I sterted
» to peel around the 4th day after wounding. I’m still clueless about the
» window issue and I didn’t inhibit wnt at all.
Day 6.
It doesn’t look like I’m going to peel until Day 8 maybe even Day 10. I’m a bit worried about not having enough of the topical to apply after the skin starts peeling as I’m not sure that applying it to the damaged skin is doing anything. It’s probably not even getting through. I got two friends to tell me if I stink due to the dmso and they say there is no smell. Not confirmation itself that the topical is not getting through but I am concerned that it may not be penetrating the damaged outer layers.
I do know that it has never taken this long to peel before so this must be the deepest I’ve ever gone.
The entire scalp is tight now with ripplings on the top. Some minor peeling begun on the top of the forehead at ‘teenage hairline’ level. I ceased wnt inhibition on Day 3 as you will get no result if wnt is inhibited during ‘the window’. I didn’t want to risk fouling up the attempt. I’ve begun to apply topical lithium although, like I say, I don’t know whether it is getting through the damaged, leathery skin.
Hats off to you guys for leaping ahead and experimenting with this stuff yourselves. Do you really believe it’s going to grow lots of hair back? Has anyone tried this before and suceeded or are you guys the first?
» Hats off to you guys for leaping ahead and experimenting with this stuff
» yourselves. Do you really believe it’s going to grow lots of hair back?
» Has anyone tried this before and suceeded or are you guys the first?
Many people have had success to one degree or another, myself included. What I’m hoping and aiming for is a serious cosmetic improvement.
» couldn’t using the egf inhibitor slow the skin making process and push the
» window back?
that did cross my mind but like Mike, who donated the gefit topical, I didn’t want to risk missing the window. I don’t even know whether the topical is getting through but to conserve some of it, I’m only going to use 1ml a day until the peeling commences. I’ve a feeling that regardless of what day it is numerically, the window starts when peeling starts.
» » Sorry, I just came back from vacation and I didn’t have access to a
» » computer. I started getfitnib 24 hours after last wounding and I
» sterted
» » to peel around the 4th day after wounding. I’m still clueless about
» the
» » window issue and I didn’t inhibit wnt at all.
»
» Day 6.
» It doesn’t look like I’m going to peel until Day 8 maybe even Day 10. I’m
» a bit worried about not having enough of the topical to apply after the
» skin starts peeling as I’m not sure that applying it to the damaged skin is
» doing anything. It’s probably not even getting through. I got two friends
» to tell me if I stink due to the dmso and they say there is no smell. Not
» confirmation itself that the topical is not getting through but I am
» concerned that it may not be penetrating the damaged outer layers.
» I do know that it has never taken this long to peel before so this must be
» the deepest I’ve ever gone.
» The entire scalp is tight now with ripplings on the top. Some minor
» peeling begun on the top of the forehead at ‘teenage hairline’ level. I
» ceased wnt inhibition on Day 3 as you will get no result if wnt is
» inhibited during ‘the window’. I didn’t want to risk fouling up the
» attempt. I’ve begun to apply topical lithium although, like I say, I don’t
» know whether it is getting through the damaged, leathery skin.
I started signs of peeling on the 3-4 days, but it started to really peel from 7-8 days on. The funny thing about it is that the 2nd experiment is when I thought the peeling was over with, another light coat of scabs formed over the scalp and that eventually peeled off. Plus, I had another peeling but it was just on certain areas. The peeling and scabing lasted a hile.
» I started signs of peeling on the 3-4 days, but it started to really peel
» from 7-8 days on. The funny thing about it is that the 2nd experiment is
» when I thought the peeling was over with, another light coat of scabs
» formed over the scalp and that eventually peeled off. Plus, I had another
» peeling but it was just on certain areas. The peeling and scabing lasted a
» hile.
Day 7 and it’s started to peel on the edges of the treated area. This is PROBABLY the beginning of ‘the window’. I have to say that a strong chemical peel seems the way to go if you want a uniformly formed wound. Sanding tends to be inaccurate and some areas peel and others do not. Going by the hypothesis that AREA of wound is important, I think that a good chemical peel is more likely to produce desired results.
» » I started signs of peeling on the 3-4 days, but it started to really
» peel
» » from 7-8 days on. The funny thing about it is that the 2nd experiment
» is
» » when I thought the peeling was over with, another light coat of scabs
» » formed over the scalp and that eventually peeled off. Plus, I had
» another
» » peeling but it was just on certain areas. The peeling and scabing
» lasted a
» » hile.
»
» Day 7 and it’s started to peel on the edges of the treated area. This is
» PROBABLY the beginning of ‘the window’. I have to say that a strong
» chemical peel seems the way to go if you want a uniformly formed wound.
» Sanding tends to be inaccurate and some areas peel and others do not. Going
» by the hypothesis that AREA of wound is important, I think that a good
» chemical peel is more likely to produce desired results.
I would say lasers 1st, chemical peels 2nd, sanding 3rd.
Guys, I’m a bit confused here. Isn’t WNT signaling the critical element here? Because that is the thing Dr. Cotsarelis’ research paper was all about. Yet most of the discussions seem to be about EGFR inhibition?
» Guys, I’m a bit confused here. Isn’t WNT signaling the critical element
» here? Because that is the thing Dr. Cotsarelis’ research paper was all
» about. Yet most of the discussions seem to be about EGFR inhibition?
What Mike is saying is that the results he got are without any external wnt measures. He used purely EGF inhibition via topical application of a synthetic drug. Two of the things that theoretically increase both generated follicle count and size of the follicles are EGF inhibition AND wnt signalling. The act of wounding itself kicks in the wnt signalling but you can UPREGULATE this even further by application of lithium compounds which mimick wnt upregulation.
In the mouse studies, the mice grew follicles that produced unpigmented hair UNLESS wnt was inhibited for a number of days before boosting it. Cotsarelis states that this anomaly was probably a feature of mouse skin which does not carry pigmentation in it’s epithelial make-up. Human skin most likely does not need the inhibition period and one can go straight to the boosting stage. At least, that’s how I understand it anyway.
Baccy, I would add one caveat. as you get older wnt actually inhibits healing and produces scars. i attached an article from stanford that says wnt inhibits improves the healing process.
here is an excerpt:
Rando said many drugs can block Wnt signaling. “Theoretically, given the number of ways to block Wnt and Wnt signaling, one could envision this becoming a therapeutic,” he said. “You could potentially enhance the healing of aged tissues by reducing this effect of Wnt signaling on the resident stem cells.”
In addition to helping the elderly heal faster and better from muscle injuries, Rando said, the potential benefits could include tissues such as skin, gut and bone marrow, or for that matter, potentially any tissue, such as liver and brain, in which stem cells contribute to normal cellular turnover.
Rando and his colleagues made the discovery while studying the effect of environment on muscle stem cell activity in mice. Rando had already discovered that old muscle stem cells, if placed in a youthful environment, had just as great a capacity for repairing acutely damaged tissue as do young cells.
» hello Baccy can you give me your email to exchange information on hair
» follicles morphogenesis
»
» I am using a formula seems to yours.
»
» regards
Mike
I’m sorry but I don’t understand
have you seen any results on your scalp?
» » hello Baccy can you give me your email to exchange information on hair
» » follicles morphogenesis
» »
» » I am using a formula seems to yours.
» »
» » regards
»
» Mike
» I’m sorry but I don’t understand
» have you seen any results on your scalp?
Yes, I have. I don’t have much time these days but when I do, I’ll post about it.
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