.
»
» If its not adro sensitive, how would you anticipate its response to DHT?
» Would it be immediate, or gradual? Even if it is adro sensitive, wouldn’t
» chronic use of one of the current anti-andros be enough to provide years
» (if not a decade or more) of retention?
I think the usage of finasteride or some new topical anti-androgen would help someone probably keep this new EDHIN hair until extreme old age because that hair will never experience the full androgenic onslaught that all our hairs did from puberty until the time we got on finasteride.»
I know of one experiment that added high androgen stimulis to ex vivo hair follicles taken from occipital scalp (back and sides), and it showed that even just enough testosterone (not to mention dihydrotestosterone) could make the ‘donor’ hairs “sensitive” to androgens. The hairs in the frontal scalp have more androgen receptors on them. If we could “seed” as many androgen receptors on hairs located in the occipital scalp…I wonder if eventually those hairs would become sensitized to androgens also.
The EXCITING THING about FOLLICA’S method to me FCKHRLS is that as we learn about what genes are associated with androgenic alopecia, like the one(s) located on chromosome 20, and the particular variant of the androgen receptor gene that 98.6% of all balding men had in that german study, just perhaps we will be able to inhibit these genes during the “hair making” process of those 2 weeks or so post-wounding. That might guarantee hairs with very little androgen sensitivity. Thats an encouraging thought.
I think its important that people try and keep the hairs FOLLICA’S wounding process makes, because miniaturized hairs will still have full sized (even larger in fact) sebacous glands and the arrector pilli muscles are still there also. Plus, the miniaturized hairs never stop being an immune target and inflamme the whole area of the balding scalp. It would be good to keep the hairs made up there because in ensuing passes, that area of the scalp will be getting crowded with first and second “generations” of hairs if someone simply let them miniaturize and “did the process again”. The “yield” may not be as high if someone kept on doing it over and over.
» If the procedure works, I just don’t think the andro sensitivity will be
» that big of an issue for most clients. I know I’d much rather have a
» procedure that produces andro-sensative follicles that require some sort of
» maintenance regiment than undergo an invasive procedure by “doctors” who
» “specialize” in a nearly unregulated practice. Further, I’d also be much
» more willing to have repeat procedures (say every 2-5 years or so) to
» replace newly formed and lost andro-sensative hair than to let one of those
» “doctors” take a knife to my scalp.
»
» If their protocol involves an HT, I would think its commercial success
» would be significantly limited when compared to one that does not. Most
» people have no trouble going to a medi-spa and getting some form of
» outpatient cosmetic treatment (laser hair removal, dermabrasion, etc.); a
» significantly less number of people would be willing to undergo serious
» cosmetic surgery. If it works, it will either produce andro-resistant hair
» (unlikely), or it will be considered a repeat procedure (which is actually
» a preferred business model from a revenue stand-point). I really don’t see
» it being an adjunct to HTs.
My thoughts on Follica “in the donor area” is that even if the hairs done in the front are just as andro-sensitive as the ones already there, we AT LEAST know that we can indeed make more “donor” hair via follica, and “re-charge” our donor areas if we had already had a procedure in the past. There are quite a few men out there who have had transplants whose donor area is thin-looking and needs to be buffed up. Of course it would be a much more elegant solution for them to be able to make more hair upfront that is not androgen sensitive and I indeed hope that is the case, but the former possibility is a “worse case scenario”. We KNOW this works. We have seen pics of two cancer patients who had been on chemo and had taken getfitinib grow large terminal hair where large terminal hair shouldn’t be (whisker-like hairs on a guy’s nose, and terminal hair right in the frontal middle of a long-bald head…dark hair of high quality, proving that it was ‘new’). Id be genuinely suprised if Follica and Aderans both failed to work at least some. Intercytex kind of led us all on, and probably just wasn’t having very good results, but they were merely culturing inductive cells and shooting them into the dermis and hoping the stem cells would direct them to make new hairs. These other two approaches are more advanced than that.
however, maybe not when applied topically. Do you have any insights on this ?