You might also want to try adding Lysine.
We have also discovered that administration of lysine to patients results in a dramatic increase in the efficacy of known treatments for genetic hair loss (which term covers a number of conditions variously referred to as androgen-dependent alopecia, androgenic alopecia, androgenetic alopecia, common baldness, female baldness, diffuse hair loss and male pattern baldness).
Thus, in a further aspect of the present invention there is provided a kit including a plurality of separate containers, each containing at least one active agent useful in a combination therapy for the treatment of genetic hair loss, wherein said kit includes L-lysine and at least one further active agent selected from minoxidil, anti-androgens, 5α-reductase inhibitors, aromatase inhibitors and corticosteroids.
There is also provided a therapeutic combination for the treatment of genetic hair loss comprising L-lysine and at least one further active agent selected from minoxidil, anti-androgens, 5α-reductase inhibitors, aromatase inhibitors and corticosteroids.
Typical examples of anti-androgens which can be used include cyproterone acetate, spironolactone, medroxyprogesterone acetate and flutamide which can, for example, be formulated for oral or topical administration. Type I, type II or mixed type I and type II 5 α-reductase inhibitors can be used, e.g. finasteride. A typical example of a suitable corticosteroid is dexamethasone.
In a preferred embodiment, the kit comprises L-lysine and at least one further active agent selected from minoxidil and one or more anti-androgens, which are preferably chosen from cyproterone acetate, spironolactone and medroxyprogesterone acetate. In a particularly preferred embodiment, the kit comprises L-lysine which is formulated for oral administration and minoxidil which is formulated for topical application.
The co-administration of L-lysine with known treatments for genetic hair loss such as minoxidil and anti-androgens results in a significant improvement in the efficacy of the treatment. The reason for this improvement in efficacy is not currently understood.