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Looks like the same substance


#1

A team of scientists from South Korea has created a chemical that can prevent hair loss and promote hair growth. Known as PTD-DMB, the substance has been shown to work on mice, and it is now being tested for toxicity before human trials are considered.

http://www.sciencedirect.com/science/article/pii/S0022202X17315555


#2

And the lead researcher on this, Dr. Kang-Yell Choi, is not some fringe guy or quack either, he’s a very respected scientist who was trained at Purdue and Harvard. He’s in the same league as Cotsarelis. There’s even this Wikipedia article on him:


#3

"So, with PTD-DBM in place, the Wnt signaling pathway can function as normal and thus hair growth continues as normal. This development so far, has only been tested on mice."
We have to wait till it’s done on human scalp. I remember Aderans managed to regrow fully terminal hairs on the whole hairless mice with multiplied cells that so badly failed on humans.


#4

From the article:

The inhibitory effects of CXXC5 on alkaline phosphatase activity and cell proliferation were demonstrated using human hair follicle dermal papilla cells. Moreover, CXXC5−/− mice displayed accelerated hair regrowth

From what I’ve found Dr. Kang-Yell, Choi was working on an Osteoporosis therapy when he stumbled upon the potential hairloss solution by blocking the CXXC5 in human skin. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818757/


#5

So basically, the CXXC5 hair growth inhibition part has been proven with human cells, and PTD-DMB has been proven effective to block CXXC5 in mice, but not yet in humans.


#6

This is certainly the most promising news in years.


#7

Promising yes but just another link in the complex puzzle.