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ICX grows hair follicles in vitro- new patent


#1

A totally new procedure or is this what Icx-trc has evolved to? A partially formed hair follicle that is injected with some kind of medium? Could this be the what the second cohort was injected with?

Intercytex are no amateurs at least! I dont think anyone have grown hair follicles in vitro before?

http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO2007109223&F=0&QPN=WO2007109223

Abstract :

This invention relates to methods of producing hair folliclesin vitro, compositions for producing hair follicles in vitro, in vitro produced hair follicles, methods of providing an in vitro produced hair shaft at an interfollicular or intrafollicular site, methods of treating hair loss by providing an in vitro produced hair shaft at an interfollicular or intrafollicular site and assays for studying the effect of test agents on hair biology. The invention also provides the similar methods and products which are, or use, immature follicles (“defined herein as proto- hairs”).The invention provides a method for in vitro production of a hair follicle or a proto-hair comprising co-culturing dermal papilla cells with keratinocytes, and optionally with melanocytes.


#2

Yes, this is totally new in the sense that this is not what is being currently tested by ICX in the Phase II clinical trials. This is “second generation” HM.


#3

How is it second generation HM John?


#4

» How is it second generation HM John?

Someguy, it’s HM 2.0 because this is growing new follicles (or follicle precursors) OUTSIDE of the scalp, and then inserting them into the scalp much in the manner of conventional HT.

In HM 1.0, they are injecting CELLS into the scalp, which will then become follicles.


#5

» » How is it second generation HM John?
»
» Someguy, it’s HM 2.0 because this is growing new follicles (or follicle
» precursors) OUTSIDE of the scalp, and then inserting them into the scalp
» much in the manner of conventional HT.
»
» In HM 1.0, they are injecting CELLS into the scalp, which will then become
» follicles.

Pherhaps HM 2.0 for the hairline and HM 1.0 for the rest?


#6

» Yes, this is totally new in the sense that this is not what is being
» currently tested by ICX in the Phase II clinical trials. This is “second
» generation” HM.

If they just got the patent, it means that they’ve known about this for years already. I wouldn’t be surprised if they are testing this as well right now.

Basically what they’re doing is culturing DP cells together with other skin cell types to produce a result that’s closer to a complete hair follicle, but not actually a complete follicle yet. It doesn’t sound that much different from what we thought of as HM before.

Here’s the gist of what it is:

“As defined herein, a proto-hair is a precursor of a mature hair follicle. We have for the first time produced such proto-hairs in vitro. A proto-hair may be considered as a part-formed follicle. It can be identified and isolated at a stage of development between the dermal papilla cell stage and the fully formed follicle stage. A proto-hair has a structure which develops from the dermal papilla cell but is no longer a dermal papilla cell as such. The structure of the proto-hair is also not that of a follicle, but it can be seen to have elements of follicle-like structure. A proto-hair is capable of further development. It can develop into a mature hair follicle in a suitable in vitro culture. It can also develop into a mature hair follicle if implanted into a recipient : this means that an in vitro produced proto-hair can subsequently produce a mature hair follicle in vivo.”

“It has now surprisingly been found that hair follicles can be produced in vitro by co- culturing dermal papilla cells with keratinocytes, with the optional addition of melanocytes.”

“The present invention provides an in vitro method for production of a hair follicle comprising co-culturing a dermal papilla cell with a keratinocyte, and optionally with a melanocyte.”


#7

» A totally new procedure or is this what Icx-trc has evolved to? A partially
» formed hair follicle that is injected with some kind of medium? Could this
» be the what the second cohort was injected with?
»
» Intercytex are no amateurs at least! I dont think anyone have grown hair
» follicles in vitro before?
»
» http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO2007109223&F=0&QPN=WO2007109223
»
» Abstract :
»
» This invention relates to methods of producing hair folliclesin vitro,
» compositions for producing hair follicles in vitro, in vitro produced hair
» follicles, methods of providing an in vitro produced hair shaft at an
» interfollicular or intrafollicular site, methods of treating hair loss by
» providing an in vitro produced hair shaft at an interfollicular or
» intrafollicular site and assays for studying the effect of test agents on
» hair biology. The invention also provides the similar methods and products
» which are, or use, immature follicles (“defined herein as proto-
» hairs”).The invention provides a method for in vitro production of a hair
» follicle or a proto-hair comprising co-culturing dermal papilla cells with
» keratinocytes, and optionally with melanocytes.

To me, it would be a very way to go. Imagine, you could create as many hair as you want and you could control the direction as a FUE. :slight_smile:


#8

» » How is it second generation HM John?
»
» Someguy, it’s HM 2.0 because this is growing new follicles (or follicle
» precursors) OUTSIDE of the scalp, and then inserting them into the scalp
» much in the manner of conventional HT.
»
» In HM 1.0, they are injecting CELLS into the scalp, which will then become
» follicles.

I’m guessing that 2.0 will be used along with 1.0, but in areas that 1.0 won’t be as effective, much like HTs are expected to be used in conjunction with HM to recreate hairlines.


#9

» I’m guessing that 2.0 will be used along with 1.0, but in areas that 1.0
» won’t be as effective, much like HTs are expected to be used in
» conjunction with HM to recreate hairlines.

ESP,

Yes, 2.0 can be used with 1.0, but notice that it’s only 1.0 that’s going through official clinical trials now. They haven’t even begun trials with 2.0. So when 1.0 comes out, 2.0 will not be ready yet.


#10

» » I’m guessing that 2.0 will be used along with 1.0, but in areas that 1.0
» » won’t be as effective, much like HTs are expected to be used in
» » conjunction with HM to recreate hairlines.
»
» ESP,
»
» Yes, 2.0 can be used with 1.0, but notice that it’s only 1.0 that’s going
» through official clinical trials now. They haven’t even begun trials
» with 2.0. So when 1.0 comes out, 2.0 will not be ready yet.

–sorry, I meant to imply that to occur in the future.


#11

Yes John.
You know I’ve wanted Intercytex and Aderans to mulitply and grow mature hairs in the lab for years. Then just implant them ONE-BY-ONE into the scalp like traditional FUE.
It may take 10 trips to the doctor’s office and much $$$$ to complete a full head of hair, but who cares.
This solves the “direction of growth” problem, and the “hairline” problem.


#12

» Yes John.
» You know I’ve wanted Intercytex and Aderans to mulitply and grow mature
» hairs in the lab for years. Then just implant them ONE-BY-ONE into the
» scalp like traditional FUE.
» It may take 10 trips to the doctor’s office and much $$$$ to complete a
» full head of hair, but who cares.
» This solves the “direction of growth” problem, and the “hairline” problem.

sounds great,
sounds just like the kind of thing to keep the investor money rolling with, with no proof that it works


#13

» sounds great,
» sounds just like the kind of thing to keep the investor money rolling
» with, with no proof that it works

how do you think they got the investors in the first place? how do you think they got the additional million in funding before phase 2?

they’ve showed proof that it works.

just because they havent showed photos of turning a guy with an ass bald head into John Kerry and John F Kennedy hair doesn’t mean it doesnt work.


#14

» » sounds great,
» » sounds just like the kind of thing to keep the investor money rolling
» » with, with no proof that it works
»
» how do you think they got the investors in the first place? how do you
» think they got the additional million in funding before phase 2?
»
» they’ve showed proof that it works.
»
» just because they havent showed photos of turning a guy with an ass bald
» head into John Kerry and John F Kennedy hair doesn’t mean it doesnt work.

whre did they show proof that it works, to the investors, I want to see the proof, other than their word saying it works

show me the pics?

the investors are greedy, dumbasses who all they need for PROOF is ICXs own report
they are so eager to believe it will work, just the same as you guys, that this is all the proof they need to shell out their money


#15

they have posted pics of the actual hairs growing that’s what he’s trying to tell you fucking jackass. that’s why nobody takes you serious. you’re sitting around waiting for somebody to post a link for you and nobody even reponds, lol. there have been multiple threads showing the pics of HM genius. you come off like such a prick so nobody seems to post the link for you when you come on here with those childish rants. i have the link bookmarked. you think ICX have a conspiracy theory against shareholders and the public so its pointless to post it here for you.

give me a coupla super vitamins and i’ll think about it, hahahahahaha…


#16

» they have posted pics of the actual hairs growing that’s what he’s trying
» to tell you fucking jackass. that’s why nobody takes you serious. you’re
» sitting around waiting for somebody to post a link for you and nobody even
» reponds, lol. there have been multiple threads showing the pics of HM
» genius. you come off like such a prick so nobody seems to post the link
» for you when you come on here with those childish rants. i have the link
» bookmarked. you think ICX have a conspiracy theory against shareholders
» and the public so its pointless to post it here for you.
»
» give me a coupla super vitamins and i’ll think about it, hahahahahaha…

pity the poor bald guys on this board have so much anger

chin up there fellow it will all be over in a few years, by the time ICX has HM, you will be too old to afford it or need it

if that pic that was posted with about 5 new hairs is supposed to be what HM has to offer, you guys hey, go for it, 5 new hairs a year
should only take you about 1000 yrs to get a new head of hair


#17

» if that pic that was posted with about 5 new hairs is supposed to be what
» HM has to offer, you guys hey, go for it, 5 new hairs a year
» should only take you about 1000 yrs to get a new head of hair

In the 1st trial ICX reported an average of 66 new hairs out of 100 injections. But what good is that or pictures if you assume that ICX is a fraud anyway? Pictures can be forged. If you assume that ICX is a fraud, no amount of evidence is sufficient.


#18

» » if that pic that was posted with about 5 new hairs is supposed to be
» what
» » HM has to offer, you guys hey, go for it, 5 new hairs a year
» » should only take you about 1000 yrs to get a new head of hair
»
» In the 1st trial ICX reported an average of 66 new hairs out of 100
» injections. But what good is that or pictures if you assume that ICX is a
» fraud anyway? Pictures can be forged. If you assume that ICX is a fraud,
» no amount of evidence is sufficient.

I assume they COULD be pulling our leg, but I can be convinced with evidence
you cannot argue with the truth, Its there in your face, like it or not , it is what it is

If they had evidence of signifant regrowth of hair, nobody could argue with that, it would be foolish. I thought they were going to inject these guys 1000 times in one year, whatever happened to that

66 new hairs per 100 injections? how much are the injections? what type of hairs are these? peach fuzz or did they turn terminal


#19

» If they had evidence of signifant regrowth of hair, nobody could argue
» with that, it would be foolish. I thought they were going to inject these
» guys 1000 times in one year, whatever happened to that
»
» 66 new hairs per 100 injections? how much are the injections? what type of
» hairs are these? peach fuzz or did they turn terminal

the hairs looked pretty terminal in the photos when they showed it recently. the good thing about phase 1 is that they weren’t even trying to grow hairs. they were testing it for safety issues.

i’d be more interested to see what happens with the phase 2 guys around spring.


#20

The guy is actually enjoying the attention. If he has such a big problem with hm just let him stick with his own vitamin therapies. It’s as simple as that.

» A totally new procedure or is this what Icx-trc has evolved to? A partially
» formed hair follicle that is injected with some kind of medium? Could this
» be the what the second cohort was injected with?
»
» Intercytex are no amateurs at least! I dont think anyone have grown hair
» follicles in vitro before?
»
» http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO2007109223&F=0&QPN=WO2007109223
»
» Abstract :
»
» This invention relates to methods of producing hair folliclesin vitro,
» compositions for producing hair follicles in vitro, in vitro produced hair
» follicles, methods of providing an in vitro produced hair shaft at an
» interfollicular or intrafollicular site, methods of treating hair loss by
» providing an in vitro produced hair shaft at an interfollicular or
» intrafollicular site and assays for studying the effect of test agents on
» hair biology. The invention also provides the similar methods and products
» which are, or use, immature follicles (“defined herein as proto-
» hairs”).The invention provides a method for in vitro production of a hair
» follicle or a proto-hair comprising co-culturing dermal papilla cells with
» keratinocytes, and optionally with melanocytes.