» Just for the sake of thought…what do you think might
» happen if someone used a pin to “injure” the scalp like Costarialis has in
» recent experiments and injected some DP cells isolated from the papillas of
» donor follicles in the wound?
» Think any neogenic actions going on in healing there might incorporate the
» DP cells of the donor area follicle?
» I know, Im nosy;-)
I think it might result in a couple hairs from DP cells that rest at the dermal/epidermal connection and are signaled by the epithelial cells lying above them, but nothing to write home about. In fact, a similar technique works pretty well in mice, but has been shown to not fair so well in humans. Now if you add some WNT to the mix, all bets are off. The problem is of course, you won’t be able to source any WNT (and it could result in safety issues if you did manage to locate some).
The wound response was a big factor in a many of the Oliver/Jahoda experiments. When you wound your skin, stem cells from the follicle bulge rush up to repair the wound. When you wound your follicle, stem cells from the same pool migrate down to repair the damage. So the wound response is a known factor in signaling follicular repair. In fact, the early Oliver experiments of the latter 60’s exploited the wound signals present from amputating the follicle in order to grow new end bulbs with normal fiber production.