Interesting study, Hinokitiol may stimulate hair growth.
http://lib.bioinfo.pl/paper:18537078
Study on HIF-1 (hypoxia),
Can’t say I know much about this topic but in general I have low hopes for a chemical cure for baldness.
Chasing down obscure pathways that might stimualte this or inhibit that to me is a dead end.
The last great breakthrough was identifying DHT as the culprit for major hair loss.
For a chemical cure, it takes a TON of money and a lot of time to get anything through the FDA which is why no pharma will pursue it unless its earth shattering in results.
» Can’t say I know much about this topic but in general I have low hopes for
» a chemical cure for baldness.
»
» Chasing down obscure pathways that might stimualte this or inhibit that to
» me is a dead end.
In general, I agree with you Freddie. I have always been skeptical about chemical cures.
The PGD2 thing is different, in my view, and from my perspective with an undergrad degree in Biochemistry plus graduate studies in the subject, I see the PGD2/receptor thing as totally, qualitatively different from all the bogus proposed chemical “cures” that have been trotted out across this and other websites over the years.
I and the others may be wrong, but I also have to defer to the wisdom of Dr. Cotsarelis and his group on this. Let’s give them a chance and see what they can produce. Meanwhile, a lot of people are self experimenting, and in this case at least, I see that as a good thing.
At the very least, it will give us INFORMATION.
» » Can’t say I know much about this topic but in general I have low hopes
» for
» » a chemical cure for baldness.
» »
» » Chasing down obscure pathways that might stimualte this or inhibit that
» to
» » me is a dead end.
»
» In general, I agree with you Freddie. I have always been skeptical about
» chemical cures.
»
» The PGD2 thing is different, in my view, and from my perspective with an
» undergrad degree in Biochemistry plus graduate studies in the subject, I
» see the PGD2/receptor thing as totally, qualitatively different from all
» the bogus proposed chemical “cures” that have been trotted out across this
» and other websites over the years.
»
» I and the others may be wrong, but I also have to defer to the wisdom of
» Dr. Cotsarelis and his group on this. Let’s give them a chance and see
» what they can produce. Meanwhile, a lot of people are self experimenting,
» and in this case at least, I see that as a good thing.
»
» At the very least, it will give us INFORMATION.
The PGD2 stuff is a dead end as well. It already is a dead end from the lack of ANY results. The solution to baldness is surgical.
» The PGD2 stuff is a dead end as well. It already is a dead end from the
» lack of ANY results. The solution to baldness is surgical.
The problem is, there is ZERO evidence of surgical success in creating new hair, either.
» » The PGD2 stuff is a dead end as well. It already is a dead end from the
» » lack of ANY results. The solution to baldness is surgical.
You are not here to contribute anything constructive.
Go away.
» I and the others may be wrong, but I also have to defer to the wisdom of
» Dr. Cotsarelis and his group on this. Let’s give them a chance and see
» what they can produce. Meanwhile, a lot of people are self experimenting,
» and in this case at least, I see that as a good thing.
»
» At the very least, it will give us INFORMATION.
What’s great about PGD2 inhibition is that it plugs the hole that dutasteride is unable to plug, which is blocking the effect of testosterone on the hair follicle. While dutas blocks DHT, its unable to do anything about testosterone’s effect on the follicle. PGD2 is probably a molecule that sits downstream from T & DHT’s action on destroying the hair follicle.
So in theory, dutasteride + PGD2 blockers should be the strongest prevention of MPB money can buy.