[quote][postedby]Originally Posted by HairlossCurse[/postedby]
Roger_that is an update available?[/quote]
Gosh, this sounds like such a big deal to have someone log in for a few minutes and answer some questions.
These guys likely are too busy picking up shirts from drycleaners or perhaps I understand, they were filling up on gas instead of answering some questions, or perhaps Dr. Cotsarelis was busy having quality elevator time conversation on the way up at UPenn…
Dr. Cotsarelis, sure you have a net connection, could you take a break from checking emails and log in for a sec… Hello!!
Dr. Cotsarelis this post is meant with full respect of course, but come’ on, I am sure a Dermatologist can find a minute in his day to answer a few intelligent questions from the world at large.
Guys i emailed yesterday luis garza telling him that our community wants an intereview and very friendly he told me to email him the questions to answer.I have done this in the past so guys start to write your questions to send to him
We know from Cots and Garzas publication that exposure of hair follicles to PGD2 has shown to result in complete inhibition of hair growth.
What we do not know however, is whether or not it has been observed that antagonism of the CRTH2 receptor actually can spur hair growth, or at least prevent further hair loss.
It would be great to know whether or not Dr Garza or his colleagues have conducted further research in this direction.
[quote][postedby]Originally Posted by georgex6[/postedby]
Guys i emailed yesterday luis garza telling him that our community wants an intereview and very friendly he told me to email him the questions to answer.I have done this in the past so guys start to write your questions to send to him[/quote]
Q: Do you have an update on the when the clinical trial will begin?
Q: MPB hair follicles grow as normal on immunodeficient mice is this because they do not produce pgd2?
Q: Why dont transplanted hairs get affected by pgd2?
Q: Do you plan on testing(in the clinical trial) pro-growth factors (eg pge2) as well?
Q: hairmans question
[quote][postedby]Originally Posted by HairlossCurse[/postedby]
Q: Do you have an update on the when the clinical trial will begin?
Q: MPB hair follicles grow as normal on immunodeficient mice is this because they do not produce pgd2?
Q: Why dont transplanted hairs get affected by pgd2?
Q: Do you plan on testing(in the clinical trial) pro-growth factors (eg pge2) as well?
Q: hairmans question[/quote]
-You have demonstrated that Neogenesis+Lithium creates “neogenic-like” hair follicles in vivo in humans. Do these automatically become terminal hairs or is there another treatment necessary?
-Is inhibiting production of PGD2 a more promising pathway or inhibiting the CRTH2 receptor?
" -You have demonstrated that Neogenesis+Lithium creates “neogenic-like” hair follicles in vivo in humans. Do these automatically become terminal hairs or is there another treatment necessary?"
The DIY experimenters’ lack of regrowth with topical Lithium has answered that question pretty clearly. But it’s worth asking Cots about it.
I think whatever is being created by that process is not close to viable topical follicles. I also doubt that Cots will ever give away anything too useful.
Wanna squeeze something relevant out of Cots for a change?
Then stop letting him get away with references to “proto-follicle structures” as if they are the genuine article that we all need. Ask him some pointed questions about whether they are currently producing cosmetically/commercially viable patches of terminal hair.
IMHO they are probably still years away from doing what they like to give the impression they are already doing - scuffing the skin of trial patients, topically applying an existing drug, and curing their MPB just like that.
I doubt anybody has askied him how to go from “neogenic-like follicles” to terminal follicles. Their clinical protocol was designed to creat NL-follicles and not terminal ones.
He won’t tell us anything that could be of practical DIY use, I’m sure of that. But his reaction to the line of questioning about what kind of “follicles” they are able to create may be revealing.
Also, IMHO its always worth asking what kind of timeline to a commercial product they are predicting.
The rosy predictions are worthless, we all know that.
But it’s potentially useful if they say something like they are still “5-10 years away”. (That translates as: “We have no f*cking idea if this will even work at all”.)
Q.) How come Follica are trying to treat baldness by creating entire new follices when Dr George Cotsarelis and you (Garza) know that the follicles are still present, just need to be reactivated? Why arent they trialling GPR44 blockers instead?
This is an advertising site for paid
advertisers to showcase successful hair restoration results only. It is not the
mandate of this site to engage in the discussion of failed, unsuccessful
procedures, lawsuits, litigations, refunds or complaint cases. Surgical hair
restoration procedures carry risks. Please do thorough research, consult your
own physician and investigate a doctor's background carefully before making a
decision. By proceeding to use our site, you agree to abide by our Terms of Use & Privacy Policy at http://hairsite.com/terms-of-use/ where you can also find a list of HairSite's sponsoring physicians.