There has never been anything even remotely like this in the history of hair science. The amount of research going on out there in this field is phenomenal. And these are just the researchers who chose to come and talk about the subject.
When Dr. Gho first tried to go and talk about HM at one of these conventions, he was banned and treated like he was a whack (However, he was allowed to do a presentation at a later date, which is one of the things that first began to open up minds in the professional community and drive this research toward the mainstream). But this is exactly how science always progresses. Somebody out there has to break the ice and make the subject safe to talk about. Some years after that, the subject becomes not only safe to talk about, it becomes the most rewarding subject a researcher can discuss. I think perhaps the most flattering thing for Gho these days is that ARI amended his early patent and is trying to grab a piece of his pie. I’m quite certain it disturbs him, but OTOH, it is the highest form of flattery a research can be provided.
It is remniscent of when a 14-year-old Farnsworth invented the television, but RCA grabbed all the money for the invention. IOW, it takes more than just an inventive mind to bring these things into fruition. Business plays every bit as big a role (or perhaps bigger) than the invention itself. I predicted many years ago that a time would come when this research finally hit the mainstream, and we would see a mad scramble toward the cash cow. I think we are at the very beginning of that period right now. If HM works, it is going to blow the field of stem cell science wide open. If it turns out not to work, it will represent a minor setback for the stem cell field as a whole, but research will continue to progress despite this.
A quick study of scientific and medical progression shows what has ocurred, is occuring, and is about to occur has happened repeatedly throughout history and is representative of the cycle that inventions often progress through before they become mainstream. But make no mistake, I believe there is still a lot of work to be done before we will see this as a marketable treatment. I’m inclined to think it is a minimum of 3-years away and will take much longer than that to reach most clinics in the USA.
Session 1 – Stem Cells
08:00 – 10:00 Co-chairs: George Cotsarelis, Colin Jahoda, Takashi Matsuzaki, Kurt Stenn
08:00 – 08:50 Cancer-initiating cells: From leukemia to solid tumors John Dick
08:50 – 09:00 Questions
09:00 – 09:15 Hair Follicle Stem Cells - Epithelial George Cotsarelis
09:15 – 09:20 Questions
09:20 – 09:30 Stem Cells of Human Hair Follicles Can Differentiate Into Neurons: Region-Specific Multipotency of Human Hair Follicle Stem Cells Yasuyuki Amoh
09:30 – 09:40 Adult Stem Cell Compartment Changes in Androgenetic Alopecia Demonstrate Maintenance of Progenitor Stem Cells With Loss of Descendant CD200 High A6 Integrin High Expressing Cells Luis Garza
09:40 – 09:50 Adult Hair Follicle Dermal Papillae Induce Hair and Skin Differentiation From Adult Corneal Epithelium James Waters
09:50 – 10:00 Bone morphogenetic protein signaling is required for hair induction by dermal papilla cells Michael Rendl
Session 2 – Mesenchymal Stem Cells
Co-chairs: Andrew Messenger, Manabu Ohyama
10:30 – 10:35 Overview tbc
10:35 – 11:25 Skin-derived Precursors (SKPs) and Induction of Hair Follicle Morphogenesis Freda Miller
11:25 – 11:50 Manipulating gene expression in the dermal papilla of the mouse in vivo Bruce Morgan
11:50 - 12:15 Mesenchymal-Epithelial Interactions needed for tissue engineering of hair follicles Colin Jahoda
Session 3 – Tissue Engineering
13:45 – 15:00 Co-chairs: Satoshi Itami, Valerie Randall, Michael Philpott
13:45 – 14:00 Tissue Engineering of Hair follicles Kurt Stenn
14:00 – 14:10 Regeneration of Human-Mouse Chimeric Follicles in a Hybrid Patch Assay Ying Zheng
14:10 – 14:20 Methods of Follicular Cell Implantation for Hair Multiplication
Jeff Teumer
14:20 – 14:30 Expression of TGF Beta2 in Cultured Human Dermal Papilla Cells and Its Ability of Induction of Tissue Engineered Hair Follicles Keita Inoue
14:30 – 14:40 In Vitro Generation of Human Hair Follicle Bud Oriented Cellular Mass Composed of Dermal Papilla Cells and Keratinocytes Shigeyoshi Fuziwara
14:40 – 14:50 The Hair-Inducing Clonal Cell Lines From Dermal Papilla and Dermal Sheath Cells of Mouse Vibrissa Follicles Aki Osada
14:50-15:00 Large-Scale Production of Dermal Papilla Microtissues Via Facilitated Self-Assembling: Implications For Hair Follicle Engineering and Dermal Papilla Physiology Sung-Jan Lin
Session 5 – Morphogenesis
Follicular Cycling 08:00 – 10:30 Co-chairs: Cheng Ming Chuong, Phillip Hynd, Ralf Paus
08:00 – 08:50 Ebling Lecturer: Wnt and Notch Signaling pathways in development and cancer of the gut Hans Clevers
08:50 – 09:20 New Insights into Telogen Cheng Ming Chuong
09:20 – 09:50 Wnt Signaling in the control of hair follicle development
Sarah Millar
09:50 – 10:00 Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin Following Wounding Mayumi Ito
10:00 – 10:10 P-Cadherin Is a p63 Target Gene With a Critical Role in the Developing Limb Bud and Hair Follicle. Angela Christiano
10:10 – 10:20 The Wnt Inhibitor, Dickkopf 4, Is Induced By Canonical Wnt Signaling During Ectodermal Appendage Morphogenesis Hisham Bazzi
10:20 – 10:30 Molecular Signature of the Follicular and Glandular Types of Epidermal Differentiation: Evidence That BMP Signaling Suppresses Trans-Differrentiation of the Foot Pad Epidermis Towards Folliculogenesis
Vladimir Botchkarev
Session 6 – Follicular Growth Controls 11:00 – 12:00 Co-chairs: Colin Jahoda, Sarah Millar, Hideoki Ogawa
11:00 – 11:30 Controlling hair follicle morphogenesis through polyubiquitination Anthony Oro
11:30 – 12:00 Hedgehog functions in the pilosebaceous unit Andrzej Dlugosz
Session 12 – Hair Treatments: What’s on the Horizon
13:30 – 15:05 Co-chairs: Shigaku Ikeda, Andrew Messenger, Jerry Shapiro
14:10 – 14:25 Nanoparticle-based Targeting of Skin Antigen-Presenting Cells via Hair Follicles Annika Vogt
