From Cotsarelis Patent

Stem cell; cell based hair therapy
1

Read the cotsarelis patent:

"ENHANCEMENT OF EDIHN BY ADMINISTRATION OF MINOXIDIL

[000235] To determine the effect of minoxidil on EDIHN, recombinant FGF is administered 11 days after incisional wounding, as decribed in Example 11. Minoxidil administration enhances HF formation, showing that new HF can be generated by (a) disrupting the epidermis; and (b) administering a minoxidil."

I will read the whole document on:

2

Can you report in written form the following Cotsarelis’ interview? Please:

http://www.sciencefriday.com/newsbriefs/read/117

3

» Can you report in written form the following Cotsarelis’ interview?
» Please:
»
» http://www.sciencefriday.com/newsbriefs/read/117

Thank you haircoach for that great information. A five millimeter wound is needed, it CANNOT BE SUTURED BACK UP—but has to heal normally (wound management), and hairs will be unpigmented. WNT protiens need to be present.

All these things are what I have thought about concerning this approach, and know I know the hurdles that will have to be overcome for this to be a hair replacement option thanks to what you have just linked. I appreciate it.

Most of the needling guys are probably going to shallow. Getting lithium chloride or whatever is easy enough, but the wounds are too shallow and I imagine most of these men aren’t letting the wounds heal normally (which means bleeding for several hours I imagine from all the pin-pricks). I thought this might be the case…

Boston Baldy will no doubt find this interesting.

4

This makes sense – and the wounding most guys are doing (the few that are, at least) is probably too shallow. We need exposed, open wounds that have regenerative rather than repair conditions operating. But man… Cotsarelis’ work is exciting!!!

» » Can you report in written form the following Cotsarelis’ interview?
» » Please:
» »
» » http://www.sciencefriday.com/newsbriefs/read/117
»
»
»
» Thank you haircoach for that great information. A five millimeter wound is
» needed, it CANNOT BE SUTURED BACK UP—but has to heal normally (wound
» management), and hairs will be unpigmented. WNT protiens need to be
» present.
»
»
» All these things are what I have thought about concerning this approach,
» and know I know the hurdles that will have to be overcome for this to be a
» hair replacement option thanks to what you have just linked. I appreciate
» it.
»
»
» Most of the needling guys are probably going to shallow. Getting lithium
» chloride or whatever is easy enough, but the wounds are too shallow and I
» imagine most of these men aren’t letting the wounds heal normally (which
» means bleeding for several hours I imagine from all the pin-pricks). I
» thought this might be the case…
»
»
» Boston Baldy will no doubt find this interesting.

5

» This makes sense – and the wounding most guys are doing (the few that are,
» at least) is probably too shallow. We need exposed, open wounds that have
» regenerative rather than repair conditions operating. But man…
» Cotsarelis’ work is exciting!!!
»
»
» » » Can you report in written form the following Cotsarelis’ interview?
» » » Please:
» » »
» » » http://www.sciencefriday.com/newsbriefs/read/117
» »
» »
» »
» » Thank you haircoach for that great information. A five millimeter wound
» is
» » needed, it CANNOT BE SUTURED BACK UP—but has to heal normally (wound
» » management), and hairs will be unpigmented. WNT protiens need to be
» » present.
» »
» »
» » All these things are what I have thought about concerning this
» approach,
» » and know I know the hurdles that will have to be overcome for this to be
» a
» » hair replacement option thanks to what you have just linked. I
» appreciate
» » it.
» »
» »
» » Most of the needling guys are probably going to shallow. Getting
» lithium
» » chloride or whatever is easy enough, but the wounds are too shallow and
» I
» » imagine most of these men aren’t letting the wounds heal normally
» (which
» » means bleeding for several hours I imagine from all the pin-pricks). I
» » thought this might be the case…
» »
» »
» » Boston Baldy will no doubt find this interesting.

6

If this works you could do it in the donor region after you remove the hair for transplanting. the wounds would be deep enough and it could replenish your donor. Interesting.

» » This makes sense – and the wounding most guys are doing (the few that
» are,
» » at least) is probably too shallow. We need exposed, open wounds that
» have
» » regenerative rather than repair conditions operating. But man…
» » Cotsarelis’ work is exciting!!!
» »
» »
» » » » Can you report in written form the following Cotsarelis’ interview?
» » » » Please:
» » » »
» » » » http://www.sciencefriday.com/newsbriefs/read/117
» » »
» » »
» » »
» » » Thank you haircoach for that great information. A five millimeter
» wound
» » is
» » » needed, it CANNOT BE SUTURED BACK UP—but has to heal normally
» (wound
» » » management), and hairs will be unpigmented. WNT protiens need to be
» » » present.
» » »
» » »
» » » All these things are what I have thought about concerning this
» » approach,
» » » and know I know the hurdles that will have to be overcome for this to
» be
» » a
» » » hair replacement option thanks to what you have just linked. I
» » appreciate
» » » it.
» » »
» » »
» » » Most of the needling guys are probably going to shallow. Getting
» » lithium
» » » chloride or whatever is easy enough, but the wounds are too shallow
» and
» » I
» » » imagine most of these men aren’t letting the wounds heal normally
» » (which
» » » means bleeding for several hours I imagine from all the pin-pricks).
» I
» » » thought this might be the case…
» » »
» » »
» » » Boston Baldy will no doubt find this interesting.

7

Your idea for FUE transplants/wound healing, was the same way back when I first heard of this. Im suprised no docs have pursued it.

Basically all a doc would have to do is put some wnt-upping substance on the donor area right after a FUE surgery, and the patient would have to be willing to sleep with a neck brace upright for the first week or so…and theoretically they’d regrow donor hairs in the donor area, albeit white hairs. It makes perfect sense to me.

Im suprised no doc jumped on this. It would be at least as good as Coen Gho’s idea.

Sometimes I think that if a solution is staring people right in the face, but its too easy, they want to disregard it.

8

I have used minoxidil almost immediately following my last several transplants. I did NOT notice anything that would give me reason to believe that this actually works. I did not, however, apply it to the donor (FUE) areas.