I have an idea…the wounds in the mice experiments in Nature were 1-2 centimeters in diameter.
One could make 4-5 different wounds and try four or five different approaches all at once, and get the various combos “tried” at the same time.
I really think that a topical immunosuppressant that inhibits T-cell responses is probably going to be necessary.
If you think about the human skin experiments at follica where human hair was grown on SCID mice, they done so with just wounding. The mice dont have immune systems. No EGF-antagonists were used. Its experiment number 7 in the patent.
We know via experiment seven that mice were abraded, and in seven days hair placodes were detected in their skin. So if you dont abrade too deeply…whatever is going to happen will happen fairly quickly. If one allowed for 2-3 extra days, that would be 10 days past wounding.
I also think that using shampoo or any water on the abraded area is just adding an uneccessary variable. The mice in the experiments were not washed, so neither should someone hoping to replicate the experiment. The patent says “no anti-infectives” should be used up there after wounding for up to two weeks thereafter. Thats 14 days. Thats another reason to advocate only wouding a small area in the front or back that you can avoid letting water or shampoo touch in my opinion.
I’ll probably give it one more try, but it may be a few months or even the beginning of the year before I can do so. I’ll eliminate all variables at that point and wound, wait about four days, and use getfitinib and cyclo for about five straight days. I wont wash the abraded area. If I get nada…you can pretty much forget anyone having a home result. Then we will all know.
BTW-----I dont pay attention to any of these posters who come on here (for whatever personal reason) and mock and make fun of anyone trying any of this stuff. I really cant for the life of me figure out why David Tse allows these folks to spam up their forum with what must be a big hobby in their spare time. Just ignore them and dont reply to them. If one of us gets some hair growth up there, nobody is going to talk it away. If one of us has success, then we can all follow what that person did to a “T” and expect the same.
I do stand by my observation about immunity. I think T-cell responses are going to have to be muted for this to really go. If not, then why dont more men with sunburns on their shoulders get more hair growth there? Ive been sunbunrt several times in years past where my skin peeled (think about how many layers would be damaged for you to peel…way down there, mitigating the skins ability to have epidermal growth factor even participate in the healing). Why dont more of them get hairy shoulders? We have immune systems. Hideo Uno remarked that stuptailed macaque balding (most of those apes bald) does not dispaly inflammation or excessive collagenous deposition as humans do, or no extra gathering of immuno cells at the base of the follicles as is seen histologically in human androgenic alopecia.
I think the immune system will have to be inhibited at least topically for EDIHN to work in real people. I’d like to be wrong about that, but in all the experiments with human skin, the mice were SCID mice. The two human hair growth photos we know of are of people who were in chemotherapy, and thus had very weakened immune response.
I mean what I say about the five different nickel-to-quater-sized wounds. You could try your five favorite approaches and “get it out of the way” by doing so.