» For the first eight days I ate an antibiotic (doxi…? dont remember) since
» I read in the patent that mice who fed on this for nine days grew pigmented
» hair. But they were geneticly altered so it may not have this effect on
» humans.
Yeah those mice are altered so as to express dkk1 in their skin after exposure to that particular antibiotic. Its a common sort of thing with GM (genetically modified) animals. The antibiotic acts as a promoter to express the gene.
» 48 hours after the wounding I started applying an immunosuppresant (Elidel
» cream) once a day for 9 days. I am not sure why immunosuppresant are in the
» patent but I figured that maybe it suppresed the Wnt signaling and caused
» pigmentation of the hair. Took a gamble on that one.
Interesting. I was curious as to how something in this class of drugs (tacrolimus, pimecrolimus, cyclosporine) would effect the process. On the one hand they seem to put stem cell proliferation into overdrive. On the other hand there is a paper that shows that at least some part of the immune response (macrophage recruitment) is necesaary for the stimulus of hair growth in response to wounding so I thought it might be unhelpful as well.
» I think Lithium might indeed be very useful, but not without the EGF-R
» inhibition to kick-start the whole process.
»
»
»
» As for Gentifib issues, I’m willing to try oral Leflunomide for the 10
» days that we’re talking about. It’s easier to get, much cheaper, and also
» a whole lot less of a counterfeit risk than Gentifib.
»
» Taking oral Arava might not be fun. But honestly, the idea of having to
» take a full 1-mg dosage of Finasteride for that window of time scares me a
» lot more. My body was really kicking me in the groin when I subjected it
» to 1/2mg of Fin.
Also, I believe part of the problem you (Debris) didn’t see any results is that you didn’t wound the skin layer ie. some method of dermabrasion. Needling just does not accomplish this… its a totally different protocol. IMO people got some results with this and minox is because it allowed for better penetration of the stuff into the area of the skin where it needed to be.
» » Thanks for continually laying this stuff out in english, Benji. I think
» » many of us really appreciate it. We appreciate your
» thoughtful observations also Cal. There is no harm in discussing a patent.
» We aren’t doing anything of ill will.
» » »
» »
» » One thing:
» »
» » - I still wonder about the Loniten/Minox factor. Yep, me
» too.
» »
» » Do you have any thoughts about whether they’re literally talking about
» » putting regular topical Minox onto the wound as part of the protocol?
» Or
» » are they only considering systemic Loniten pills (probably for fear of
» » alcohol disruption to the healing process)? I wonder about
» this also. The patent says topical. Minox has been shown to effect areas
» other than applications (even swollen hands in some folks----like I had
» somewhat back in the day). I had thought perhaps to use a generous amount
» of topical minox on either side of the application area would probably get
» some of it spreading through the capillaries to the wound. I have also
» thought about using arginine as a NO agonist and just not using a potassium
» channel opener.
» »
» » I also wonder whether the whole benefit gained from the Minox/Loniten
» is
» » very significant or not. Ive wondered about this also. It
» was in example 14 in the first patent. It “enhanced” the amount of hairs
» grown similar to fiberblast growth factor (which would be more of a hassle
» to obtain than minoxidil).
»
» Cal, the simpleist embodiment of the patent that they patent-protected was
» the wounding, plus the 1)egf-antibody 2)finasteride 3) minox.
» We know they grew -some- hair on human skin with wounding alone in example
» 7.
»
»
»
» I have an idea that perhaps you, I, TAGOHL if he is
» interested, and any other guy could do to test this in a way that wouldn’t
» be detrimental to our scalps or any kind of risk.
» There are other areas where a man might want a little more hair. Perhaps
» one of your eyebrows is thicker than the other one? My right one is a
» little larger than my left. Maybe the skin on the side of your head above
» your ears has a little more space than youd like before the occipital
» hairline started. Nobody can see behind someones’ ear.
» Perhaps one side of the nape of your neck has a smidgen more hair than the
» other…
» These would be places that someone could run a little test of perhaps a
» square inch or so of skin.
»
» Im openly thinking about it by doing this:
» Wounding and waiting about four good days.
» Applying minox on either side of the wound from day four to ten.
» Using milk thistle extract twice a day from day four to ten.
» Not washing or letting water or soap touch the abraded area from the
» wounding day until day ten.
» Perhaps, just perhaps…taking a little lithium chloride (few
» pinches of it sprinkled as a salt on something) from day four through
» ten.
»
»
» Cal, I ordered Arava (hasn’t come yet, way past due), but perhaps you or
» TAGOHL has had success obtaining the egf-inhitors listed in the patent.
» TAGHOL has mentioned something about wounding his jawline. I have a pretty
» hairy beard, so if I grew hair on my jawline above normal, I’d have a hard
» time telling. Nevertheless, if you and TAGHOL ran a little test somewhere
» like behind the ear, above (or below) the eyebrow, the nape of the neck
» with the synthetic drug, and I did it with the milk
» thistle…none of us washed the area…we’d all
» pretty much have copped the patents simpleist embodiment as closely to the
» vest as possible. If all three of us didn’t get anything, we’d know that
» either the immunosuppressant, the anti-histamine, the retinoid, or the
» anti-microbial was necessary, or that it just wont work in humans being.
»
» I might try this next week. Hell if I seen hair four weeks after the
» little run, or you guys did…we’d know that follica will
» work.
»
» If I was “safe” in the knowledge that follica will work…I’d
» probably set up an appointment with a FUE doc pretty
» soon…safe in the knowledge that a few years down the line
» follica could “do” my donor area and make “more” donor hair. I think many
» of us would feel the same way. Eight or ten hairs being “made” is all Id
» really need to know about in vivo in any one of us. If “we” can do that
» much, imagine what follica could do with their resources…
so… your saying it would work on eyebrows benji? i guess i got lost in technicality’s.
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