Finasteride in the treatment of men with frontal male pattern hair loss.
J Am Acad Dermatol. 1999 Jun;40(6 Pt 1):930-7.
University of Pennsylvania School of Medicine, Philadelphia, USA.
Abstract
BACKGROUND: Finasteride, a specific inhibitor of type II 5alpha-reductase, decreases serum and scalp dihydrotestosterone and has been shown to be effective in men with vertex male pattern hair loss.
OBJECTIVE: This study evaluated the efficacy of finasteride 1 mg/day in men with frontal (anterior/mid) scalp hair thinning.
METHODS: This was a 1-year, double-blind, placebo-controlled study followed by a 1-year open extension. Efficacy was assessed by hair counts (1 cm2 circular area), patient and investigator assessments, and global photographic review.
RESULTS: There was a significant increase in hair count in the frontal scalp of finasteride-treated patients (P < .001), as well as significant improvements in patient, investigator, and global photographic assessments. Efficacy was maintained or improved throughout the second year of the study. Finasteride was generally well tolerated.
CONCLUSION: In men with hair loss in the anterior/mid area of the scalp, finasteride 1 mg/day slowed hair loss and increased hair growth.
» Finasteride in the treatment of men with frontal male pattern hair loss.
»
» J Am Acad Dermatol. 1999 Jun;40(6 Pt 1):930-7.
»
» University of Pennsylvania School of Medicine, Philadelphia, USA.
»
» Abstract
» BACKGROUND: Finasteride, a specific inhibitor of type II 5alpha-reductase,
» decreases serum and scalp dihydrotestosterone and has been shown to be
» effective in men with vertex male pattern hair loss.
»
» OBJECTIVE: This study evaluated the efficacy of finasteride 1 mg/day in men
» with frontal (anterior/mid) scalp hair thinning.
»
» METHODS: This was a 1-year, double-blind, placebo-controlled study followed
» by a 1-year open extension. Efficacy was assessed by hair counts (1 cm2
» circular area), patient and investigator assessments, and global
» photographic review.
»
» RESULTS: There was a significant increase in hair count in the frontal
» scalp of finasteride-treated patients (P < .001), as well as significant
» improvements in patient, investigator, and global photographic assessments.
» Efficacy was maintained or improved throughout the second year of the
» study. Finasteride was generally well tolerated.
»
» CONCLUSION: In men with hair loss in the anterior/mid area of the scalp,
» finasteride 1 mg/day slowed hair loss and increased hair growth.
It would help to know how many men were involved in the study…
» » Finasteride in the treatment of men with frontal male pattern hair loss.
» »
» » J Am Acad Dermatol. 1999 Jun;40(6 Pt 1):930-7.
…
» It would help to know how many men were involved in the study…
That’s the problem - they didn’t mention it - A JOKE!
img/uploaded_files/2879_file31.pdf
(discussed study in full)
The following is THE REALITY concerning “Propecia/Finasteride” …
Tuesday, March 1, 2011
Dangers of Merck’s Hairloss medicine
This Blog is intended to raise awareness of the dangers of the medication propecia, a hormone blocker used for male pattern baldness.
Finasteride was marketed as a medication that had minimal side effects and no biological mechanism to cause systemic effects on men. In fact, subsequent data has been published that the rate of side effects are high, that the drug is potentially very harmful, and long term effects are unknown. Yet, the drug is still being marketed and sold to young men who believe that they are saving their hairlines while not doing damage to the rest of their bodies. Here is the evidence:
While the initial studies performed by Merck suggested a less than 2% to 4% rate of sexual side effects, subsequent independent studies have shown much higher levels, including up to 30% in one prospective randomized study, and a relative risk of greater than 2 with a number needed to harm of 81 individuals in a systematic review (1-3). It is notable that in the 5 year long term study, the rate of sexual side effects in the Merck studies, while low, is still statistically significant (4).
While initial studies performed by Merck related researchers show no impact on spermatogenesis or semen production, subsequent reports suggesting strong cause and effect correlation by independent investigators are concerning (5-7).
Animal studies looking directly at corpus cavernosal changes after finasteride exposure have shown abnormal changes of the corpus cavernosum and tunica albuginea (8). The corpus cavernosum is the spongy tissue that expands to allow for an erection to occur. The tunica albuginea is the tough elastic tissue surrounding the corpus cavernosum that traps blood (so long as the inflow pressure is high enough) once an erection has occurred.
Normal corpus cavernosum:
READ MORE …
Iam only glad that we dont have to eat those pills in the future again