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Dutasteride - Planning on having babies? Then read


#1

I came across this in another forum by a long term and respected poster. I say that because being acquainted on the forums a very long time, his words are reliable to me.

Please read the following as it is a Medical Director’s point of view on Dutasteride, its side effects, and most importantly effecting new born babies while on the drug.

My sister in law has her PhD in Pharmacy from University of RI and is now the managing director of an international pharmaceutical firm that specializes in consulting on drug interactions.

I asked about the long term effects of Avodart and the hormonal effect on testosterone, etc. Here is her response:

Since Avodart is also used to treat enlarged prostate, it does have similar side effects as Propecia. Detailed below:

  • Since it is used to treat enlarged prostate it would most likely alter your PSA levels, which is a measurement specific to your prostate. (when your prostate is enlarged, the PSA is higher and results in urinary retention and other symptoms. Also, elevated PSA is often a marker for prostate cancer, so when you use Avodart for enlarged prostate it helps relieve the urinary retention and decreases the PSA).

  • Guidelines recommend that you DO NOT donate blood while taking Avodart or for at least 6 months after discontinuation due to risk of fetal harm (birth defects) for pregnant women who receive transfusions with the blood. Also, I don’t think that you’re planning on having any more babies () but just in case Avodart is contraindicated due to the risk of fetal harm

  • Possible sexual dysfunction problems and breast enlargement (based on effects on testosterone). (The drug works by inhibiting the enzyme that converts testosterone to DHT). In clinical trials, it did not have a statistically significant effect on estrogen levels, cholesterol levels or bone mineral density (ie. Test for osteoporosis); however, it did have significant effects on testosterone and TSH (a thyroid hormone)- Your doctor could test this with a simple blood test to ensure it is not altered. After discontinuation of Avodart, these blood levels returned to normal.

  • It is heavily metabolized through the liver so could be concerns with long-term use (no data seems alarming and they don’t recommend any blood test for monitoring, but it could be of concern- since you were asking for long-term risks). (Also, lots of drug interactions so if you ever take any other medications ask the pharmacist/doctor about possible interactions)

I couldn’t find anything on fluid retention and based on the drug’s mechanism of action it shouldn’t cause a problem. There are rare reactions that can cause localized edema (swelling) but you would have already experienced that if it were going to happen.

So far, it seems like you are not experiencing the side effects experienced with Propecia and usually if these side effects are going to happen it occurs in the beginning and resolves by 3-6 months. If you are concerned about your general practitioner monitoring any blood levels, they could test your PSA, TSH, testosterone and liver enzymes to make you feel better about any risks it may potentially have on blood levels.


So I followed up with this question to which you will see her response:

“however, it did have significant effects on testosterone and TSH (a thyroid hormone)”

The effects on testosterone: did it lower the testosterone level ? and what did it do to the TSH ? How will this impact me ? If my testosterone level is lower I think my sense of overall well being is altered and my workouts will be impacted as well ?

Response:

Decreases testosterone thus effects on libido and sexual dysfunction. I would think could effect your stamina/energy for workouts. If you experience a decreases in TSH could make you feel tired and could also make you end up gaining weight but TSH changes are less common.


As an avid gym rat and outdoor guy I was not thrilled with the decreased testosterone level’s – given that I will be 48 years old at the end of the month and my levels drop each year on their own as it is.

Thoughts or comments ?


9/17/04 - 6279 Graphs
1/11/07 - 4128 Graphs

Total: 10,407

Doctor Hasson


#2

Hairsite,

I could have sworn I posted this thread in the “Propecia, Avodart, Spiro, DHT & hormones …” section of the forum. My mistake I guess, can you please remove it from here and place it where it belongs.

Thanks

MJ


#3

» I came across this in another forum by a long term and respected
» poster. I say that because being acquainted on the forums a very long time,
» his words are reliable to me.
»
» Please read the following as it is a Medical Director’s point of view on
» Dutasteride, its side effects, and most importantly effecting new born
» babies while on the drug.
»
»
» My sister in law has her PhD in Pharmacy from University of RI and is now
» the managing director of an international pharmaceutical firm that
» specializes in consulting on drug interactions.
»
» I asked about the long term effects of Avodart and the hormonal effect on
» testosterone, etc. Here is her response:
»
» Since Avodart is also used to treat enlarged prostate, it does have
» similar side effects as Propecia. Detailed below:
»

Dutasteride raises testosterone.
»
» * Since it is used to treat enlarged prostate it would most likely alter
» your PSA levels, which is a measurement specific to your prostate. (when
» your prostate is enlarged, the PSA is higher and results in urinary
» retention and other symptoms. Also, elevated PSA is often a marker for
» prostate cancer, so when you use Avodart for enlarged prostate it helps
» relieve the urinary retention and decreases the PSA).
»
» * Guidelines recommend that you DO NOT donate blood while taking Avodart
» or for at least 6 months after discontinuation due to risk of fetal harm
» (birth defects) for pregnant women who receive transfusions with the blood.
» Also, I don’t think that you’re planning on having any more babies ()
» but just in case Avodart is contraindicated due to the risk of fetal harm
»

»
» * Possible sexual dysfunction problems and breast enlargement (based on
» effects on testosterone). (The drug works by inhibiting the enzyme that
» converts testosterone to DHT). In clinical trials, it did not have a
» statistically significant effect on estrogen levels, cholesterol levels or
» bone mineral density (ie. Test for osteoporosis); however, it did have
» significant effects on testosterone and TSH (a thyroid hormone)- Your
» doctor could test this with a simple blood test to ensure it is not
» altered. After discontinuation of Avodart, these blood levels returned to
» normal.
»
» * It is heavily metabolized through the liver so could be concerns with
» long-term use (no data seems alarming and they don’t recommend any blood
» test for monitoring, but it could be of concern- since you were asking for
» long-term risks). (Also, lots of drug interactions so if you ever take any
» other medications ask the pharmacist/doctor about possible interactions)
»
» I couldn’t find anything on fluid retention and based on the drug’s
» mechanism of action it shouldn’t cause a problem. There are rare reactions
» that can cause localized edema (swelling) but you would have already
» experienced that if it were going to happen.
»
» So far, it seems like you are not experiencing the side effects
» experienced with Propecia and usually if these side effects are going to
» happen it occurs in the beginning and resolves by 3-6 months. If you are
» concerned about your general practitioner monitoring any blood levels, they
» could test your PSA, TSH, testosterone and liver enzymes to make you feel
» better about any risks it may potentially have on blood levels.
»
» ****************
»
» So I followed up with this question to which you will see her response:
»
»
» “however, it did have significant effects on testosterone and TSH (a
» thyroid hormone)”
»
» The effects on testosterone: did it lower the testosterone level ? and
» what did it do to the TSH ? How will this impact me ? If my testosterone
» level is lower I think my sense of overall well being is altered and my
» workouts will be impacted as well ?
»
» Response:
»
» Decreases testosterone thus effects on libido and sexual dysfunction. I
» would think could effect your stamina/energy for workouts. If you
» experience a decreases in TSH could make you feel tired and could also make
» you end up gaining weight but TSH changes are less common.
»
» *****************************
»
» As an avid gym rat and outdoor guy I was not thrilled with the decreased
» testosterone level’s – given that I will be 48 years old at the end of the
» month and my levels drop each year on their own as it is.
»
» Thoughts or comments ?
»
» -------------------------
» 9/17/04 - 6279 Graphs
» 1/11/07 - 4128 Graphs
» ==========
» Total: 10,407
»
» Doctor Hasson


#4

»
» Please read the following as it is a Medical Director’s point of view on
» Dutasteride, its side effects, and most importantly effecting new born
» babies while on the drug.
» …
» * Guidelines recommend that you DO NOT donate blood while taking Avodart
» or for at least 6 months after discontinuation due to risk of fetal harm
» (birth defects) for pregnant women who receive transfusions with the blood.
» Also, I don’t think that you’re planning on having any more babies ()
» but just in case Avodart is contraindicated due to the risk of fetal harm
»

Uh, are you planning on becoming pregnant anytime soon? I don’t think most men here are going to carry fetuses in their wombs… If they do, I’ll remind them to get off Dutasteride. :smiley:

Seriously, you do realize it is contraindicated for WOMEN, not men?


#5

» »
» » Please read the following as it is a Medical Director’s point of view
» on
» » Dutasteride, its side effects, and most importantly effecting new born
» » babies while on the drug.
» » …
» » * Guidelines recommend that you DO NOT donate blood while taking
» Avodart
» » or for at least 6 months after discontinuation due to risk of fetal
» harm
» » (birth defects) for pregnant women who receive transfusions with the
» blood.
» » Also, I don’t think that you’re planning on having any more babies
» ()
» » but just in case Avodart is contraindicated due to the risk of fetal
» harm
» »

»
» Uh, are you planning on becoming pregnant anytime soon? I don’t think most
» men here are going to carry fetuses in their wombs… If they do, I’ll
» remind them to get off Dutasteride. :smiley:
»
» Seriously, you do realize it is contraindicated for WOMEN, not men?

Perhaps it could also adversely affect sperm


#6

» »
» » Please read the following as it is a Medical Director’s point of view
» on
» » Dutasteride, its side effects, and most importantly effecting new born
» » babies while on the drug.
» » …
» » * Guidelines recommend that you DO NOT donate blood while taking
» Avodart
» » or for at least 6 months after discontinuation due to risk of fetal
» harm
» » (birth defects) for pregnant women who receive transfusions with the
» blood.
» » Also, I don’t think that you’re planning on having any more babies
» ()
» » but just in case Avodart is contraindicated due to the risk of fetal
» harm
» »

»
» Uh, are you planning on becoming pregnant anytime soon? I don’t think most
» men here are going to carry fetuses in their wombs… If they do, I’ll
» remind them to get off Dutasteride. :smiley:
»
» Seriously, you do realize it is contraindicated for WOMEN, not men?

SPEMAN is a product I was looking into for myself incase Dut caused low sperm count for me. Just something I was looking into and one of the descriptions is as quoted

"Speman is considered to be one of the safest among all the herbal Viagras. The product has cent percent safe clinical reports those present it as natural herbal product with no harmful or unwanted effects. More over, the product also does not carry any contraindications and therefore, it is safe in all directions. "
http://74.125.95.132/search?q=cache:D6NaEY4JZH8J:www.herbal-supplements-for-you.com/speman.html+low+sperm+count+-+contraindications&hl=en&ct=clnk&cd=1

In other words, drugs can cause contraindications for men by effecting the sperm. Hence, fetal complications.


#7

serously this is nothing that we dont already know, what he said about dutas is true for propecia too, i wouldn’t mind seeing some long term studies about these drugs’ effects on the liver though


#8

Every single person I know that has been on propecia has had perfectly healthy babies. Unless the woman is taking propecia, that is one very long shot. You don’t think?

And if one were however on dut I would be curious to know if there was a way for him to do periodic checks to make sure he was okay to accidently get his wife pregnant one day. I don’t think it’s a simple matter of lowering the sperm count; the sperm itself becomes affected.

» serously this is nothing that we dont already know, what he said about
» dutas is true for propecia too, i wouldn’t mind seeing some long term
» studies about these drugs’ effects on the liver though


#9

That’s always been my impression about Fin & Dut. They can lower the # of sperm and make it more difficult for the sperm to make the trip, but once a baby is concieved there won’t be harm to it.