Dr. Nigam, Wnt7a suppress tumor growth

Please note that in all of the below linked studies the scientist-authors talk about an industry wide acceptance that Wnt7a has a tumor suppressing effect. This seems to mean that Wnt7a reduces the risk of cancer. This is not the opinion of a single researcher, rather this belief is widely accepted throughout the medical research community.

This first links leads to an article explaining how Wnt7a reduces the risk of lung cancer.


So then why do smokers get lunch cancer even though they have Wnt7a inside of their bodies? The study in this link below talks about that issue. I think that they’re saying that cigarette smoke alters Wnt7a in some way which could lead to the person acquiring lung cancer. It also suggests that restoring Wnt7a to it’s correct state could have a therapeutic effect on lung cancer.

And here’s another study that also indicates that it is altered Wnt7a that allows renal cancer to develop. I think this means that people’s bad habits (such as smoking), and other environmental factors, may be altering Wnt7a in ways that is leading to some renal cancers, and the researchers also seem to be saying that adding correct Wnt7a to the person’s treatment medications could possibly have a positive therapeutic effect on these renal cancer:

And here is a study wherein the scientist authors talk about the suppressing effect that Wnt7a has on tumors. It’s clear that this perceived effect is something the medical research community in general accepts rather than just one or two scientists believing this:

Here is one of the many relevant quotes from the study in the link directly above:

“In conclusion, we have shown that lost or reduced Wnt7a expression is significantly associated with poor progression-free and overall survival in patients with endometrial carcinoma. These results suggest for the first time that Wnt7a might play a role in tumor suppression in endometrial cancer. Although our results are derived from a limited number of patients, the present study provides important basis for future. Further studies on a larger cohort of patients and Wnt7a targeting molecules are warranted to validate the prognostic impact of Wnt7a expression on survival in endometrial cancer.”

Here is another article indicating that it is widely accepted that Wnt7a is a tumor suppressor:


And here is another article wherein it indicates that the tumor suppressing capabilities of Wnt7a are generally accepted:

And in a separate issue, here’s a study showing that Wnt7a reduces some cell death: