Interesting to watch Dr. Hitzig and Dr. Prasad raving about ACell+PRP on the video posted by Stevie.Dee (ACell: How to Use It).
It seems to me that Dr. Hitzig is a very intelligent man, and also has a wide range of knowledge, BUT he makes a lot of statements where he gets the science completely muddled, blurs together different scientific concepts, and passes off completely speculative opinions as known facts.
I think this is very dangerous and misleading to patients.
For instance, in that video, in which Dr. Prasad is injecting someone’s scalp with ACell and PRP solutions, Dr. Hitzig makes the following comments:
He says words to the effect that in people with MPB, there is a genetic trait which makes stem cells “go bad” so that they don’t turn into progenitor cells and thus cannot “protect” the follicle from DHT. He refers to the research from University of Pennsylvania (Dr. Cotsarelis) which he says supports this.
He says words to the effect that ACell works by activating these “bad” stem cells so that they can turn into useful progenitor cells that can protect the follicles from DHT.
First, let me tackle assertion #1 above. Yes, MPB-affected people have a genetic trait. And yes, according to Dr. Cotsarelis’ research, that genetic trait affects skin stem cells in the scalp. Dr. Cotsarelis found that people with MPB have the same number of stem cells, but fewer active “hair follicle progenitor cells” (derived from those stem cells somehow), in their scalps. But, how does Dr. Hitzig know that the result of that is that progenitor cells aren’t available to “protect the follicles from DHT”??? I think a more reasonable inference would be that DHT (in genetically-predisposed people) is the CAUSE of the stem cells not converting to useful progenitor cells… and then the lack of useful progenitor cells is the CAUSE of the follicle miniaturizing, because the progenitor cells are directly involved in the hair-germinating activity of the follicle. (Note that in Dr. Hitzig’s explanation, he doesn’t even give a plausible explanation of what DHT actually does to the follicle. I am saying that the effect of DHT is directly on the stem cells, leading to a cascade which prevents stem cells from becoming progenitor cells. Dr. Hitzig seems to have muddled up cause and effect.)
On Dr. Hitzig’s assertion #2 above, here he says that injecting ACell+PRP into the scalp will activate stem cells and cause them to convert into progenitor cells, which will promote or induce growth of the follicles. HOW DOES HE KNOW THIS???
We know that MPB people have a faulty gene, but if the cause is a bad gene and “bad” stem cells resulting from this genetics, then why would ACell work the same way on stem cells in the balding areas as it does in the non-balding areas of the scalp? In the non-balding areas, the “bad” gene is switched off, and in the balding areas, the “bad” gene is switched on.
In my opinion, if ACell is injected into balding areas, it won’t encourage those “bad” stem cells to convert into “good” progenitor cells. ACell has absolutely no effect on genes; it is a genetically inert substance that does not penetrate the cell nucleus, and doesn’t interact with DNA or RNA in any way (mostly because it is composed of macroscopic particles that can’t enter the cell membrane or nuclear membrane, although they can have effects on cells).
Rather, I would think that if ACell is injected into balding areas, the most it could do is recruit more of those “bad”, useless MPB stem cells… which wouldn’t do anything to help the balding person.
I just don’t think what Dr. Hitzig is saying sounds right…