Home | News | Find a Doctor | Ask a Question | Free

Destruction of arrector p. muscle & fat infiltration in Androgenic Alopecia

Destruction of the arrector pili muscle and fat infiltration in androgenic alopecia.

AuthorsTorkamani N, et al. Show all Journal
Br J Dermatol. 2014 Mar 3. doi: 10.1111/bjd.12921. [Epub ahead of print]

Affiliation
Abstract
BACKGROUND: Androgenic alopecia (AGA) is the most common hair loss condition in men and women. Hair loss is caused by follicle miniaturization, which is largely irreversible beyond a certain degree of follicular regression. In contrast, hair loss in telogen effluvium (TE) is readily reversible. The arrector pili muscle (APM) connects the follicle to the surrounding skin.

OBJECTIVES: To compare histopathological features of the APM in AGA and TE.

METHODS: Archival blocks of 4 mm scalp punch biopsies from 8 patients with AGA and 5 with TE were obtained. New 4 mm biopsies from 5 normal cases were used as controls. Serial 7 μm sections were stained with a modified Mason’s trichrome. “Reconstruct” software was used to construct and evaluate three-dimensional images of the follicle and APM.

RESULTS: The APM degenerated and was replaced by adipose tissue in all AGA specimens. Remnants of the APM remained attached to the hair follicle. There was no fat in the normal skin specimens. Fat was seen in 2 of 5 TE specimens, but could be attributed to these patients also showing evidence of AGA. Quantitative analysis showed that muscle volume decreased and fat volume increased significantly (P<0.05) in AGA compared to controls.

CONCLUSIONS: APM degeneration and replacement with fat in AGA has not previously been described. The underlying mechanism remains to be determined. However we speculate that this phenomenon might be related to depletion of stem or progenitor cells from the follicle mesenchyme, explaining why AGA is treatment resistant. This article is protected by copyright. All rights reserved.

This article is protected by copyright. All rights reserved.
PMID 24579818 [PubMed - as supplied by publisher]

[quote][postedby]Originally Posted by shivers20[/postedby]
Destruction of the arrector pili muscle and fat infiltration in androgenic alopecia.

AuthorsTorkamani N, et al. Show all Journal
Br J Dermatol. 2014 Mar 3. doi: 10.1111/bjd.12921. [Epub ahead of print]

Affiliation
Abstract
BACKGROUND: Androgenic alopecia (AGA) is the most common hair loss condition in men and women. Hair loss is caused by follicle miniaturization, which is largely irreversible beyond a certain degree of follicular regression. In contrast, hair loss in telogen effluvium (TE) is readily reversible. The arrector pili muscle (APM) connects the follicle to the surrounding skin.

OBJECTIVES: To compare histopathological features of the APM in AGA and TE.

METHODS: Archival blocks of 4 mm scalp punch biopsies from 8 patients with AGA and 5 with TE were obtained. New 4 mm biopsies from 5 normal cases were used as controls. Serial 7 μm sections were stained with a modified Mason’s trichrome. “Reconstruct” software was used to construct and evaluate three-dimensional images of the follicle and APM.

RESULTS: The APM degenerated and was replaced by adipose tissue in all AGA specimens. Remnants of the APM remained attached to the hair follicle. There was no fat in the normal skin specimens. Fat was seen in 2 of 5 TE specimens, but could be attributed to these patients also showing evidence of AGA. Quantitative analysis showed that muscle volume decreased and fat volume increased significantly (P<0.05) in AGA compared to controls.

CONCLUSIONS: APM degeneration and replacement with fat in AGA has not previously been described. The underlying mechanism remains to be determined. However we speculate that this phenomenon might be related to depletion of stem or progenitor cells from the follicle mesenchyme, explaining why AGA is treatment resistant. This article is protected by copyright. All rights reserved.

This article is protected by copyright. All rights reserved.
PMID 24579818 [PubMed - as supplied by publisher][/quote]

Good find! So far, it doesn’t seem any cell-based treatment will work before the environment (bald scalp) is repaired.

Can anyone find access to full article pdf ???

Home | News | Find a Doctor | Ask a Question | Terms of Use & Privacy

This is an advertising site for paid advertisers to showcase successful hair restoration results only. It is not the mandate of this site to engage in the discussion of failed, unsuccessful procedures, lawsuits, litigations, refunds or complaint cases. Surgical hair restoration procedures carry risks. Please do thorough research, consult your own physician and investigate a doctor's background carefully before making a decision. By proceeding to use our site, you agree to abide by our Terms of Use & Privacy Policy at http://hairsite.com/terms-of-use/ where you can also find a list of HairSite's sponsoring physicians.