Although I think a 0.1% solution is too weak. This is not even a 1% solution. It is a 1/10 of 1 percent solution. To compare this to minoxidil 5,% there is 50 times more active ingredient in rogaine 5% solution than in the 0.1% solution of latanprost used in the study. And even though the rogaine 5% has 50 times as much of its’ active ingredient it does not produce as much hair as the latanoprost 0.1% solution does. It really demonstrates that latanoprost is much stronger than minoxidil. I wonder what a 2% or 5% solution of latanoprost would do for hair growth.
» Although I think a 0.1% solution is too weak. This is not even a 1%
» solution. It is a 1/10 of 1 percent solution. To compare this to
» minoxidil 5,% there is 50 times more active ingredient in rogaine 5%
» solution than in the 0.1% solution of latanprost used in the study. And
» even though the rogaine 5% has 50 times as much of its’ active ingredient
» it does not produce as much hair as the latanoprost 0.1% solution does. It
» really demonstrates that latanoprost is much stronger than minoxidil. I
» wonder what a 2% or 5% solution of latanoprost would do for hair growth.
Just speculating here, and I have no idea what latanprost’s side effects are, but I’m assuming that latanprost is a parasympathomimetic – and therefore a smooth-muscle relaxant.
It may be that latanprost has much “stronger” side effects than minoxidil, so if you up the dosage (percentage of active ingredient) in latanprost by, say 10, you increase its side effects much more than you would if you increased minoxidil’s dosage by a factor of 10.
A lot of the “suggested dose” or dosing recommendations in FDA approved drugs have to do with side effects. Drugs with weak side effects or low toxicities (LD50’s) are tolerable at much higher doses than drugs with strong side effects.
I would expect for a parasympathomimetic, systemic side effects to be relaxation of smooth muscle including in the bowel; could also effect heart rate, could lower blood pressure, could dilate the pupils and also cause a whole lot of other side effects, some of them unpleasant.
I’m just speculating here, latanprost’s side effects might not be that bad. But I don’t think you can extrapolate from the recommended dosage of one drug to the other, because they all have different potencies, side effects, and metabolism, breakdown rates and rates of excretion by the kidneys.
I thought that latanoprost is bimatoprost. What exactly is the difference between latanoprost and bimatoprost?
he does not site a specific study that proves that.
This study indicates bimatoprost is better at growing hair than latanoprost and latanoprost and bimatoprost seem to work a tiny bit differently so that means that if you use latanoprost and bimatoprost you could possibly get some synergistic activity where the two combined would be better than either one alone.
Also, we already know that a 0.1% solution of latanoprost solution is safe because it was safe in that study at the top of this thread. So we know we can go at least as high as 0.1% latanoprost and get a 22% increase in hair growth.