Follicular penetration of topically applied caffeine via a shampoo formulation.
Skin Pharmacol Physiol. 2007;20(4):195-8
Follicular drug delivery is the prerequisite for an effective treatment of androgenetic alopecia or other reasons of premature hair loss.
The follicular penetration of caffeine, applied topically in a shampoo formulation for 2 min, was measured with highly sensitive surface ionization in combination with mass spectroscopy, a selective method for the detection of very small quantities of transcutaneously absorbed substances in the blood. An experimental protocol, developed to selectively block the follicular pathway within the test area, was used. Based on this principle, a clear distinction between interfollicular and follicular penetration of topically applied caffeine was feasible.
After 2 min, caffeine penetrated via the hair follicles and stratum corneum.
It was found that the penetration via hair follicles was faster and higher compared with the interfollicular route and that hair follicles are the only pathway for fast caffeine absorption during the first 20 min after application
» It was reported some time ago here that caffeine (topical) can stimulate
» hair growth. We recently received this email testimonial from one of our
» female readers.
» comments: “I have had thin hair for most of my life, exerienced
» rejvination in Switzerland using a Caffein shampoo made in Germna, and a
» great salon stylist. I returned back to MI, went to my local salon for a
» “touch-up and trim” (after my best friend - who rarely gives compliments
» said how great my hair was looking!). The stylist at home, when I went for
» the touch up - a full coloring and it did not cover my new grays at all -
» used Redken, I woke up the next day with frizzy mess…when I returned to
» Switzerland, to my horror I saw in photos new pix of my hair, totally bald
» on my part line…I am thickening back they say, new growth is already
» coming in. But wow! Using Loreal for the coloring from my “Swiss experts”
» and Loreal conditioning- my hair is again very shiny and healthy but what
» happened?! I have been using the ffeiene shampoo for nealry two yrs and
» thickened up nicely… Thanks for nay advice.”