A truth drug or truth serum is a psychoactive medication used to obtain information from subjects who are unable or unwilling to provide it otherwise. The unethical use of truth drugs is classified as a form of torture according to international law.[1] However, they are properly and productively utilised in the evaluation of psychotic patients in the practice of psychiatry.[2] That application was first documented by Dr. William Bleckwenn in 1930 [3], and it still has selected uses today. In the latter context, the controlled administration of intravenous hypnotic medications is called “narcosynthesis” or “narcoanalysis.” It may be used to procure diagnostically- or therapeutically- vital information, and to provide patients with a functional respite from catatonia or mania.
Butalbital, structure presents as 5-allyl-5-isobutylbarbituric acid, is a barbiturate with an intermediate duration of action. It has the same chemical formula as talbutal but a different structure. Butalbital is often combined with other medications, such as paracetamol (acetaminophen) or aspirin, and is commonly prescribed for the treatment of pain and headache. The various formulations combined with codeine are FDA approved for the treatment of tension headaches.