Home | News | Find a Doctor | Ask a Question | Free

A study that kills an alternative baldness theory


#1

Abstract
A controlled study of the effects of RU58841, a non-steroidal antiandrogen, on human hair production by balding scalp grafts maintained on testosterone-conditioned nude mice
B. DE BROUWER, C. TÉTELIN, T. LEROY, A. BONFILS & D. VAN NESTE0Skin Study Centre, Skinterface sprl 9 rue du Sondart-B 7500 Tournai, Belgium, 1Roussel Uclaf, Romainville, France
Correspondence to: D. Van Neste. Skin Study Centre, Skinterface sprl 9 rue du Sondart-B 7500 Tournai, Belgium
Abstract
Human hair growth can be monitored for several months after the transplantation of scalp samples from men with androgen-dependent alopecia on to female nude mice. Hair production from balding sites has been shown to be inhibited in testosterone-conditioned nude mice. We used this recently reported model to study the effect of a new non-steroidal antiandrogen — RU58841 — on human hair growth. Twenty productive scalp grafts from balding men were maintained for 8 months after grafting on to nude mice, and hair production was monitored monthly for 6 months. All mice were conditioned by the topical application of testosterone (testosterone propionate, 300 μg in 10 μL; 5 days/week) on the non-grafted flank. The scalp samples were divided equally according to the estimated hair production potential, which was based on the amount of hair present on the scalp samples before grafting. Each of the two equal groups of grafts was further allocated at random to be treated topically (5 days/week) with blinded solutions of either RU58841 1% in ethanol, or ethanol as a control.

Twenty-eight active follicles appeared on the 10 control grafts. Among them only two follicles (7%) initiated a second hair cycle. However, the 10 RU58841-treated grafts bore a total of 29 active follicles, and eight of them (28%) showed a second cycle. The values for the linear hair growth rates (LHGR) were significantly (P < 0.04) higher in the RU58841-treated group. Recycling and increased LHGR indicate a positive action for RU58841 on human hair growth from balding samples grafted on to testosterone-conditioned nude mice, and encourage a clinical trial to evaluate its potential in the treatment of androgen-dependent alopecia.

Balding follicles transplanted to mice…only two follicles initiated a second cycle despite the fact tissue scaffolds would have been formed…yet 7 follicles treated with RU58841 had a second cycle…according to someone’s theory, all of them should have a second, third, and fourth cycle due to tissue scaffolds formed around these follicles. That should settle that once and for all.


#2

» Abstract
» A controlled study of the effects of RU58841, a non-steroidal
» antiandrogen, on human hair production by balding scalp grafts maintained
» on testosterone-conditioned nude mice
» B. DE BROUWER, C. TÉTELIN, T. LEROY, A. BONFILS & D. VAN NESTE0Skin Study
» Centre, Skinterface sprl 9 rue du Sondart-B 7500 Tournai, Belgium,
» 1Roussel Uclaf, Romainville, France
» Correspondence to: D. Van Neste. Skin Study Centre, Skinterface sprl 9 rue
» du Sondart-B 7500 Tournai, Belgium
» Abstract
» Human hair growth can be monitored for several months after the
» transplantation of scalp samples from men with androgen-dependent alopecia
» on to female nude mice. Hair production from balding sites has been shown
» to be inhibited in testosterone-conditioned nude mice. We used this
» recently reported model to study the effect of a new non-steroidal
» antiandrogen — RU58841 — on human hair growth. Twenty productive scalp
» grafts from balding men were maintained for 8 months after grafting on to
» nude mice, and hair production was monitored monthly for 6 months. All
» mice were conditioned by the topical application of testosterone
» (testosterone propionate, 300 μg in 10 μL; 5 days/week) on the
» non-grafted flank. The scalp samples were divided equally according to the
» estimated hair production potential, which was based on the amount of hair
» present on the scalp samples before grafting. Each of the two equal groups
» of grafts was further allocated at random to be treated topically (5
» days/week) with blinded solutions of either RU58841 1% in ethanol, or
» ethanol as a control.
»
» Twenty-eight active follicles appeared on the 10 control grafts. Among
» them only two follicles (7%) initiated a second hair cycle. However, the
» 10 RU58841-treated grafts bore a total of 29 active follicles, and eight
» of them (28%) showed a second cycle. The values for the linear hair growth
» rates (LHGR) were significantly (P < 0.04) higher in the RU58841-treated
» group. Recycling and increased LHGR indicate a positive action for RU58841
» on human hair growth from balding samples grafted on to
» testosterone-conditioned nude mice, and encourage a clinical trial to
» evaluate its potential in the treatment of androgen-dependent alopecia.
»
»
»
» Balding follicles transplanted to
» mice…only two follicles initiated a second cycle
» despite the fact tissue scaffolds would have been
» formed…yet 7 follicles treated with RU58841 had a second
» cycle…according to someone’s theory, all of them should
» have a second, third, and fourth cycle due to tissue scaffolds formed
» around these follicles. That should settle that once and for all.

dude you have to get over this obsession with your hair, you post study after study, you theorize about ICX this ICX that, you are wearing yourself and us, out with all these posts theorizing and analyzing every nuance of every study, every theory of every company,. every supplement topical known to man

take a chill pill and try not to think about it for awhile, its only your hair

not trying to dog on you but lately it seems like every second post on the HM post is yours