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A graft model for hair development


#1

A graft model for hair development

Exp Dermatol. 2008 Jun;17(6):512-8

Follicular cell implantation (FCI) is an experimental cell therapy for the treatment of hair loss that uses cultured hair follicle cells to induce new hair formation. This treatment is based on the demonstration that adult dermal papilla cells (DPC) retain the hair inductive capacity they acquired during hair morphogenesis in the embryo.

For FCI, hair inductive cells are isolated from scalp biopsies and then propagated in culture in order to provide enough cells to generate many new follicles from a few donor follicles. Following expansion in culture, the cells are implanted into the scalp where they induce the formation of new follicles. Because the process relies on the ability to retain the potential for hair induction during the expansion of DPC in culture, we sought a consistent, reliable and easily performed in vivo assay in which to test hair induction.

In this study, we describe a simple graft model that supports hair morphogenesis. The assay combines dermal cells with embryonic mouse epidermis that provides the keratinocyte component of induced follicles. The grafts are placed under a protective skin flap in the host athymic mouse where the cells will form a skin graft with hair if the dermal cells are hair inductive DPC.

Using the assay, freshly isolated and cultured mouse embryo dermal cells as well as cultured dermal papilla cells from other species all induced hair formation. The induced hairs were aesthetically indistinguishable from those of the epidermal donor in length, thickness, and pigmentation, and they were histologically normal


#2

Damn :slight_smile:


#3

» Damn :slight_smile:


#4

Is this breaking news ? no pictures ? whats is the exact date of the study publication ?

Superfred …not that much …they implicity mentioned the difficulty of keeping the induction properties of DPs.Also that coupling with the embryonic cells and the protection at the end.


#5

» Is this breaking news ? no pictures ? whats is the exact date of the study
» publication ?
»
» Superfred : Not that much …they implicity mentioned the difficulty of
» keeping the induction properties of DPs.Also that coupling with the
» embryonic cells and the protection at the end.

Debris : " freshly isolated and cultured mouse embryo dermal cells as well as cultured dermal papilla cells from other species all induced hair formation."

It seems that it’s not a mice exclusivity, not anymore.


#6

so it is the mouse. mouse is the host.


#7

» A graft model for hair development
»
» Exp Dermatol. 2008 Jun;17(6):512-8
»
http://www.blackwell-synergy.com/doi/abs/10.1111/j.1600-0625.2007.00661.x

Original Article
A graft model for hair development

* Jizeng Qiao,
* Erica Philips and
* Jeff Teumer

*
  Intercytex Ltd, 175-E New Boston Street, Woburn, MA, USA

Jeff Teumer, Fax: 781 569 0166, e-mail: jteumer@intercytex.com

This is a article from Intercytex.

There is nothing new here.

Intercytex has been engaging in a lot of self promotion lately. There have been a number of articles written about them from various sources. Why? Probably because they need a new round of financing, that’s why.

Intercytex stock has been slowly sinking, sitting at 45p right now, down from 120p. It has lost 2/3rds of its value.

Management probably needs to get some publicity so they can get more suckers to invest money in the company so they can reward themselves with another stock grant.