Including the hair waxing 3 days beforehand, I’m now around 2 weeks into my project of playing with Leflunomide.
I did dermabrasion with sandpaper and used oral Leflunomide. Some areas were only mildly scraped, but others were damn near scarring-level wounds. (There is NO DOUBT that I abraded a few spots as deeply as Folica could possibly risk selling to the public. I was hitting blood in a few places.)
Most areas were done 4 days before the EGF-R inhibition, but a few small ones were done during the EGF-R dosing.
As for potentially interfering with the healing process, NO TOPICALS WERE USED AT ALL. The EGF-R inhibition was all with oral pills. I even washed my hair with nothing but plain water during that time.
I don’t know much. It’s too early to tell. There are definitely some faint dots and wisps of hairs starting in the abraded area, but nothing worth photographing yet. I’m at least confident that this medication/wounding is not any danger to leave an area worse than it started.
But this is interesting: The most promising signs of new hairs are occurring at the absolutely deepest-wounded spot that was also wounded DURING the EGF-R inhibition (not a few days before it).
It’s not enough to convince me to throw out the waiting period principle. But it is enough to make me think we should be experimenting with wounds during EGF-R as much as the waiting period attempts.
Also interesting: For a few days of the early healing period, the few areas in that category (deep wounds, and made during the EGF-R inhibition period) seemed to perceptibly “swell up” compared to the surrounding skin. Certainly not much swelling, but more than none at all. And it was more than the other dermabraded areas were doing, even some very deep areas.
If nothing else, this effort has convinced me that just raw dermabrasion may be worth something for us. Even if the EGF-R inhibition doesn’t prove to do anything, the faint dots/wisps of regrowth I’m starting to see are enough to surpass a lot of fraudulent hair loss crap that is being sold at a profit.
It ain’t much. But at barely 2 weeks it’s already more than nothing.