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5 AR inhibitors and semen parameters


#1

The effect of 5alpha-reductase inhibition with dutasteride and finasteride on semen parameters and serum hormones in healthy men

J Clin Endocrinol Metab. 2007 May;92(5):1659-65

CONTEXT:
Dutasteride and finasteride are 5alpha-reductase inhibitors (5ARIs) that dramatically reduce serum levels of dihydrotestosterone (DHT).

OBJECTIVE:
Because androgens are essential for fertility, we sought to determine the impact of 5ARI administration on serum testosterone (T), DHT, and spermatogenesis.

DESIGN, SETTING, SUBJECTS, AND INTERVENTION:
We conducted a randomized, double-blinded, placebo-controlled trial in 99 healthy men randomly assigned to receive dutasteride (D; 0.5 mg) (n = 33), finasteride (F; 5 mg) (n = 34), or placebo (n = 32) once daily for 1 yr.

MAIN OUTCOME MEASURES:
Blood and semen samples were collected at baseline and 26 and 52 wk of treatment and 24 wk after treatment and were assessed for T, DHT, and semen parameters.

RESULTS:
D and F significantly (P < 0.001) suppressed serum DHT, compared with placebo (D, 94%; F, 73%) and transiently increased serum T. In both treatment groups, total sperm count, compared with baseline, was significantly decreased at 26 wk (D, -28.6%; F, -34.3%) but not at 52 wk (D, -24.9%; F, -16.2%) or the 24-wk follow-up (D, -23.3%; F, -6.2%). At 52 wk, semen volume was decreased (D, -29.7%; F, -14.5%, significantly for D) as was sperm concentration (D, -3.2%; [corrected] F, -7.4%, neither significant).

There was a significant reduction of -6 to 12% in sperm motility during treatment with both D and F and at follow-up. Neither treatment had any effect on sperm morphology. CONCLUSIONS: This study demonstrates that the decrease in DHT induced by 5ARIs is associated with mild decreases in semen parameters that appear reversible after discontinuation.


#2

you cannot compare side by side, Finasteride and Dut, which both reduce SERUM DHT LEVELS, you cannot compare the effects of these two drugs , with Saw Palmetto for example, which has been shown NOT TO REDUCE serum DHT levels

reducing serum dht levels , in my opinion, is bad, and causes all the nasty side effects of loss of libido etc

Fin, DUT and Saw Palmetto are all three 5 ar inhibitors, but that does not make them equal and comparable

apparently the Naturals work in a different pathway or method which is less detrimental to the blood certainly, and to the body in general