Agree with most of what you say there.
Totally agree with that, and of course with what I said. I think the workings of the follicle are so complex that likely no one cell, or biochemical mechanism by itself, will be the basis of a cure. But, if Treg cells are the cells that activate stem cells, and stem cells are the cells that generate DP cells, then there is a strong connection between all three. Conceivably, the Treg cells could be disproportionately important because they seem to be at the beginning of that sequence.
Yes, I've seen some articles and posts with speculation about Treg cells and hair from before this recent discovery in San Francisco (specifically I found some from 2015), but it's completely conceivable they didn't really establish a firm connection until now, because sadly, there is still a lot researchers don't know. And hair loss research is seriously underfunded. Most of these recent discoveries have been happening by accident -- which means there was no one purposely trying to find them, because there isn't a great deal of basic research being done on hair loss and the follicle, compared to "debilitating" diseases.
There's a lot we don't know... For instance, what's the connection between Tregs and JAK inhibitors? There probably is one, but they won't know what it is until it's researched.
Totally agree with that. The more cell types required, the more complex any procedure would get, and the less attractive it is for commercial developers. But, let's say that they find out that adding Treg cells improves yield tremendously. Do you think at least one company won't be interested? They'll just bite the bullet and develop the treatment, even if it requires multiple cell types. So -- big disincentive to get into it from the start, but once someone shows it works well, then there's suddenly a tremendous incentive for companies to jump in.
That's exactly what they're saying, and if true, then Treg cells are definitely important for a cell-based cure. The positive thing is, they're apparently very easy to isolate from the body (you don't have to collect them from the scalp, because they exist throughout the body), and they're easy to multiply in culture. To me, this is an ideal project for Dr Kemp and HairClone.