» 0.1% Latanopros resulted in 22% more hair and that is decent results. It
» is way W-A-Y better than minoxidil.
I'm not aware of any human studies or clinical trials where latanoprost or bimatoprost has been proven to grow hair on human SCALPS.
If you're talking about tests or trials where latanoprost grew extra hair in eyelashes or eyebrows, it's not the same as growing hair on the scalp, because the receptors are different and the signaling for hair growth is different, hair on the eyelashes and eyebrows also isn't affected by MPB.
In order to prove the efficacy of latanoprost or bimatoprost for hair growth to counter MPB, we have to have trials:
1) In HUMANS, not animals like the macaque monkey...
2) On human SCALPS, not eyelashes or any other part of the body
Can you cite where, when, who did these trials that showed 22% growth?
Even if it was on a human scalp, I find it a little dubious, because the known mechanism of latanoprost is pretty much exactly the same mechanism of Minoxidil, which is to relax smooth muscles in micro-capillaries.
Of course, minoxidil and latanoprost are really two different drugs and not chemically related (latanoprost is a prostaglandin analog while minoxidil isn't), but they have pretty much the same mechanisms of action, and that is why I think they're essentially doing the exact same thing and growing hair in the exact same way.
If so, latanoprost is just prolonging the growth phase of the follicle (as Ahab said), not really growing new hair or regenerating any follicles permanently by truly reversing miniaturization.
So in other words, it's just like minoxidil. It may be a little stronger than minoxidil, but so what? The only reason we can't use very high dosage minoxidil is the SIDE EFFECTS. We'd all grow lots of hair, probably very low quality hair too, but we'd also probably die of hypotension or anaphylaxis or something! In fact, that principle is essentially the same with ANY DRUG for ANY PURPOSE. It's always a battle between efficacy and side effects.
My point is that ANY drug which has the same mode of action of minoxidil -- vasodilation -- is doomed to being a more-or-less "second rate" solution to hair loss. It's not really reversing the miniaturization process, as PGD2 might actually do. It's just prolonging the growth phase of hairs that were recently miniaturized, and it doesn't even really do a full or complete job of that... and ultimately it'll just produce a bunch of worthless crappy vellus hairs like I got when I used minoxidil.