Home | News | Find a Doctor | Ask a Question | Free

When come HM?


#1

Hi!
Iam from europe(germany),and I have a great interest to Hair-Multiplication.
Can you gave me some Infos about HM,and when we can get???
Thanks and best wishes…:slight_smile:


#2

» Hi!
» Iam from europe(germany),and I have a great interest to
» Hair-Multiplication.
» Can you gave me some Infos about HM,and when we can get???
» Thanks and best wishes…:slight_smile:

Best case (hypothetic) seems to be 4 to 5 five years away, but it’s just speculation. We don’t know for now since there has been failures recently from firms which where supposed to deliver in 2010, so here we start again. The only “legit” firm that could come up with something now is called Follica bio, that’s about all.

cheers


#3

» Hi!
» Iam from europe(germany),and I have a great interest to
» Hair-Multiplication.
» Can you gave me some Infos about HM,and when we can get???
» Thanks and best wishes…:slight_smile:
And whats about intercytex?I heard they start trial 3???


#4

Never!


#5

» Never!
Never for you but for me:-D


#6

ICX-TRC is an autologous hair regeneration therapy, a suspension of human dermal papilla cells, for the treatment of male pattern baldness and female diffuse alopecia. It is intended that ICX-TRC will be used by specialists in hair transplant centres, dermatologists and plastic surgeons to treat patients with hair thinning or hair loss.

Background

Both male pattern baldness and female diffuse alopecia result in hair-loss or slowing of hair growth. They may be caused by physical damage to the hair itself or to the hair follicles, but commonly arise as a consequence of changes in the natural growth cycle of hair generally resulting in fewer dermal papilla cells. Approximately 95% of all cases are of genetic origin.

Market opportunity

Hair loss affects approximately 40% of men and 20% of women aged 50 and over. In the US there are an estimated 40 million men and 12 million women suffering from some degree of baldness. The estimated market size for hair regeneration products and treatments is over $1 billion for both men and women but only 2% of patients suffering hair loss currently seek any treatment indicating a potentially far higher market size*.

Existing conventional treatments, involving the transplant of whole hairs, represent the only means of regenerating bald or thinning areas. This is a highly costly ($10,000 - $20,000) specialist procedure. Extensive tissue is required, obtained by the removal of a large section of scalp leaving a significant scar at the donor site. Individual follicles are removed from the dissected scalp by specialised technicians and then individually re-implanted into surgical incisions created in the scalp. This procedure usually takes place during two, eight-hour implant sessions performed under a local anaesthetic. A lengthy recovery period may be required during which time the patient may suffer from pain, bleeding and swelling of the scalp. In general the cosmetic effect is excellent, however in all cases, the quality of outcome is limited by the amount of donor hair available. Moreover, many individuals electing to undergo this procedure do not progress to transplant surgery as they have insufficient transplantable hair follicles to benefit from the technique as between 2,000 - 5,000 follicles are often needed for this procedure.

The ICX-TRC procedure is significantly less problematic than conventional hair transplants. In terms of the amount of tissue taken from the patient, only a small sample of approximately 120 follicles is needed. As a consequence, trauma suffered by the patient during the procedure may be dramatically reduced. Furthermore, as dermal papilla (DP)cells can be derived from a very small area of hair-bearing scalp, a much higher population of patients will be able to benefit from ICX-TRC than conventional transplantation. Superficial injection of cultured cells into the scalp causes far less tissue damage than implanting multiple hair follicles and is a considerably simpler, shorter and less painful process.

The ICX-TRC procedure

A small sample of hair follicles is taken from the patient during a simple 30 minute operation carried out under local anaesthetic at a hair or skin clinic. The clinic sends the biopsy to Intercytex’ GMP compliant manufacturing facility where the DP cells are dissociated from the rest of the follicle. These cells are cultured and expanded in proprietary media over three weeks and subsequently returned to the clinic in a sterile suspension.

Using a specialised delivery system, the DP cells are microinjected intradermally into the patient’s scalp. The treatment is performed under local anaesthetic and comprises a single procedure of superficial injections, each injection delivering a minute volume of media containing DP cells. These cells are able to stimulate the generation of new hairs when injected in close proximity to the epidermal cells which generate the hair. Following the procedure, new hair growth should become evident after approximately three months.

ICX-TRC clinical and commercial development

Phase I clinical trials (safety) have been completed in seven volunteers at a single UK transplant centre. No safety issues have arisen and five out of seven patients have shown increased hair numbers.

The treatment phase of a Phase II trial, being conducted by Dr Bessam Farjo in Manchester, to optimise the delivery of the DP cells, has been completed.

In this study, hair counts were obtained by shaving and photographing a small section of scalp, injecting it and then applying a specialised image analysis system to provide a total hair count. All 19 subjects in the trial have now been treated using a range of injection and scalp pre-stimulation techniques; the first six subjects were injected without stimulation of the scalp. In the remaining 13 the resident hair producing (epithelial) cells were stimulated at the time of delivery of the DP cells.

11 subjects have now passed the 24-week time point since treatment and specialised image analysis at this time point showed:

· Of the group of six patients without stimulation of the scalp, three had an increased hair count and two had a reduced hair count; one has been lost to follow-up.

· Of the five subjects with pre-treatment scalp stimulation, all had increased hair count at 12 weeks and the three who were evaluable at 24 weeks all had an increased hair count at that time point.

These data are consistent with the earlier data reported last September and the hypothesis that new hair production is improved by pre-stimulation of the scalp, leading to an interaction between the injected cells and the resident hair producing cells.

24 week data on all subjects in the trial will be available in September 2008 and at the end of the trial, photographic data will be analysed from a much larger area of treated scalp on all subjects at 48 weeks.


#7

ICX’s phase#2 results have been cryptically reported. It looks like they were disappointing compared to Phase#1. The future of ICX-TRC is unknown right now.

Follica inc. is starting human testing on a hair-regeneration technique using drugs that the FDA has already approved safe in humans for other purposes. If it works well, we may get HM within as little as 1-3 years. If Follica’s method does not work well, then we are in big trouble. We will probably not see any other HM methods being tested for at least another 5 years, maybe even 10 years or beyond.

The new “Acell” wound-healing substance that is just starting to be used in humans may also have some hair-growing potential. It has already been capable of wound-healing regrowth that we believe should have been more difficult than hair follicles. But absolutely nothing is known about the results of this stuff for hair yet.


#8

My friends…
we in Germany(europe)still waiting too at HM!
My english isnt the best and i have any problems to translat.
We heard,Foli. will start this summer trail at humans.Is this right


#9

It is very likely that Follica will be testing on humans soon. It should begin this summer (2008).


#10

» It is very likely that Follica will be testing on humans soon. It should
» begin this summer (2008).
I think it too!!!
Hopfuly,as early as possible;-)


#11

» My friends…
» we in Germany(europe)still waiting too at HM!
» My english isnt the best and i have any problems to translat.
» We heard,Foli. will start this summer trail at humans.Is this right

basically the answer is: do not expect anything earlier than 5 years from now on, and be prepared to wait 20 years or even forever.


#12

But all they say(intercytx and co.)that its come!!!But when???


#13

» But all they say(intercytx and co.)that its come!!!But when???

Sorry dude, but truth is that it is not going to be available before 2012 and chances are that it will never work. All research so far has failed. Every single one.

It can easily happen that we are all going to die bald. Deal with it.


#14

»
» Sorry dude, but truth is that it is not going to be available before 2012
» and chances are that it will never work. All research so far has failed.
» Every single one.
»
» It can easily happen that we are all going to die bald. Deal with it.

It depends what is your own way to deal in life - I have faced much more horrible stuff than hair loss (as most of us I’ll assume), but personnally I think I won’t die bold. But true, will be years before it will be on the market, but with future technologies starting to be tested/accepted to be tested (aethical issues in some cases) based on e.g. genes/ADN etc, should become a solution at some stage (and that’s not taking into account Follica ACell etc).


#15

» » But all they say(intercytx and co.)that its come!!!But when???
»
» Sorry dude, but truth is that it is not going to be available before 2012
» and chances are that it will never work. All research so far has failed.
» Every single one.
»
» It can easily happen that we are all going to die bald. Deal with it.

I’m sick of people saying ICX has failed wah wah wah, the only thing that has failed is your understanding.

Just because the results weren’t what you were expecting doesn’t make it a failure, they are very likely going to complete phase II, get a partner, complete phase III and come to market!

Injecting DP cells, sure as sh!t grows hair!, maybe not enough to densely cover your shinny top but as long as it grows some it is a success. All patients treated with pre-stimulation regrew hair!

Just because there is no small scale commercialization this year doesn’t make it a failure, just because the trial is taking longer than you want doesn’t make it a failure, Things in life very rarely go as swiftly and problem free as we’d like.
Just because they didn’t release detailed data yet doesn’t make it a failure, they are half way through a trial for god sake! why would they give details half way through.

Until the day comes when there is no more research going into TRC by anyone, and they announce that it has failed…it hasn’t failed.
They very well may do this in their next announcement, but until then…IT HASN’T FAILED YET!


#16

But whats the problem now???when ist dosnt failed???why isnt it on the market???
How long must we wait???:expressionless:


#17

» But whats the problem now???when ist dosnt failed???why isnt it on the
» market???
» How long must we wait???:expressionless:

Stevi: the problem is that it does not work yet.

It has not passed human trials, but whats worse, it has never even been tested on humans, or the things that have been tested, all failed.

There is not a single one treatment that would have worked in humans.

The day this treatment is found is a day when you can start waiting. Average cancer human trial takes 10 years and cancer is serious deadly disease. This won’t be different. The day they find something that works in humans (and they have not yet), is the day you can start hoping for 10 years only.


#18

Wow Sorry man I just realized how aggressive my previous post seems, I didn’t mean it like that, I don’t even have that much hope for TRC anymore.
I must have been in a pretty bad mood earlier.
I am hopeful that Follica are on to something with what they propose to do though, the science behind it is certainly promising, as is what Acell have.
An out right cure may be a long way off, but I’m hopeful there will be at least a promising treatment within the next 10 years.


#19

» » But whats the problem now???when ist dosnt failed???why isnt it on the
» » market???
» » How long must we wait???:expressionless:
»
» Stevi: the problem is that it does not work yet.
»
» It has not passed human trials, but whats worse, it has never even been
» tested on humans, or the things that have been tested, all failed.
»
» There is not a single one treatment that would have worked in humans.
»
» The day this treatment is found is a day when you can start waiting.
» Average cancer human trial takes 10 years and cancer is serious deadly
» disease. This won’t be different. The day they find something that works in
» humans (and they have not yet), is the day you can start hoping for 10
» years only.

This is hopelessly UNTRUE. IF Follica’s trials go well, they can go straight to market. The drugs are already FDA approved (finas/dutas and getfitinib and minoxidil). Dermabrasion is already performed every day in this nation and has no FDA oversight. There is no need for FDA trials nor will there be any FDA trials. It just has to work…thats the rub they are faced with—which is why I hope trials start in Boston over the summer.


#20

»
» This is hopelessly UNTRUE. IF Follica’s trials go well, they can go
» straight to market. The drugs are already FDA approved (finas/dutas and
» getfitinib and minoxidil). Dermabrasion is already performed every day in
» this nation and has no FDA oversight. There is no need for FDA trials nor
» will there be any FDA trials. It just has to work…thats
» the rub they are faced with—which is why I hope trials start in Boston
» over the summer.

And then.Can we hope it is in max 5 years on the market???:wink: