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What are they waiting for to start studies in humans?


#1

It’s too good to be true
http://www.m-hikari.com/asb/forth/sugayaASB1-4-2010.pdf


#2

Although we still need detailed safety studies, including the effect of PyPs on the growth of other types of cells, the current preliminary study is a stepping-stone for further studies to investigate the effect of increasing cell proliferation within the hair follicle on the pathogenesis of various alopecia conditions, which may lead to new treatments.

I think they need money for the studies …


#3

» It’s too good to be true
» http://www.m-hikari.com/asb/forth/sugayaASB1-4-2010.pdf

You should get in touch with them to see what’s going on with it. I’m sure they’ll give you the usual pitch about studies, funding blah blah blah. If human beings were to discover fire for the first time again there would be some Bureaucrat saying it needed safety studies then a decade of clinical trials, meanwhile everyone will be freezing to death.


#4

» » It’s too good to be true
» » http://www.m-hikari.com/asb/forth/sugayaASB1-4-2010.pdf
»
» You should get in touch with them to see what’s going on with it.

No - not necessary. Just send them at least 1 million dollar - that’s all they want to be in touch with.


#5

a key unanswered question is if hair follicles after years of being bald are even alive.

perhaps this might be the cure for people who just started noticing they have MPB.

but it may not be the cure for people who have already had their follicles destroyed by DHT for years.

is there even a hair follicle in a scalp which has been bald for years or is it ejected ? anyone know the answer for sure (don’t just take a bullsh&t guess)


#6

» » » It’s too good to be true
» » » http://www.m-hikari.com/asb/forth/sugayaASB1-4-2010.pdf
» »
» » You should get in touch with them to see what’s going on with it.
»
» No - not necessary. Just send them at least 1 million dollar - that’s all
» they want to be in touch with.

Ok, we can call all the bald people for that, not? Only 1$/bald. Seriously,
someone that speak fluent english want contact them to get more informations? I have the e-mail.


#7

well, the first thing to ask them is: Are they speaking of regrowth or only
of accelerated growth? I don’t understand if those mice were partially bald or not before shaving.


#8

» Seriously,
» someone that speak fluent english want contact them to get more
» informations? I have the e-mail.

Does that mean that you have serious doubts about my excellent & extraordinary perfect English skills?? :wink:


#9

» » Seriously,
» » someone that speak fluent english want contact
» them to get more
» » informations? I have the e-mail.
»
» Does that mean that you have serious doubts about my excellent &
» extraordinary perfect English skills?? :wink:

No, not you. It’s me that don’t speak English very well. If you want try the address is in the linked pdf.


#10

» ---------------
» Although we still need detailed safety studies,
» including the effect of PyPs on the growth of other types of cells, the
» current preliminary study is a stepping-stone for further studies to
» investigate the effect of increasing cell proliferation within the hair
» follicle on the pathogenesis of various alopecia conditions, which may lead
» to new treatments.
» ---------------
»
» I think they need money for the studies …

any approach which from a scientific point of view has a successful remedy for hairloss should have no problem finding funding.


#11

» well, the first thing to ask them is: Are they speaking of regrowth or
» only
» of accelerated growth? I don’t understand if those mice were partially
» bald or not before shaving.

from what i understand, they simply shaved mice and accelerated the hair growth. They also stated that the newly grown hair, not only grew very rapidly, but it also was dark black as opposed to the original hair which had been black with some grey hair. I presume if this compound works the same way on human hair, then it wld cause rapid hair growth along with increased pigmentation and probably - due to increased cell proliferation - rejuvenate vellus hair.

I wonder if the we can obtain the “heterocyclic pyrrolopyrimidine” compounds used in this study… If this bears no or minimal risk of cancerous cell proliferation, then i’m sure many of us would be willing to test this on themselves.


#12

» » well, the first thing to ask them is: Are they speaking of regrowth or
» » only
» » of accelerated growth? I don’t understand if those mice were partially
» » bald or not before shaving.
»
» from what i understand, they simply shaved mice and accelerated the hair
» growth. They also stated that the newly grown hair, not only grew very
» rapidly, but it also was dark black as opposed to the original hair which
» had been black with some grey hair. I presume if this compound works the
» same way on human hair, then it wld cause rapid hair growth along with
» increased pigmentation and probably - due to increased cell proliferation -
» rejuvenate vellus hair.
»
» I wonder if the we can obtain the “heterocyclic pyrrolopyrimidine”
» compounds used in this study… If this bears no or minimal risk of
» cancerous cell proliferation, then i’m sure many of us would be willing to
» test this on themselves.

ok, if is only accelerated growth i wonder to know why they have used the word “alopecia” …they have also tell PyP is simple to synthesize, administered orally ( though they have used shots)


#13

» » » well, the first thing to ask them is: Are they speaking of regrowth
» or
» » » only
» » » of accelerated growth? I don’t understand if those mice were
» partially
» » » bald or not before shaving.
» »
» » from what i understand, they simply shaved mice and accelerated the
» hair
» » growth. They also stated that the newly grown hair, not only grew very
» » rapidly, but it also was dark black as opposed to the original hair
» which
» » had been black with some grey hair. I presume if this compound works
» the
» » same way on human hair, then it wld cause rapid hair growth along with
» » increased pigmentation and probably - due to increased cell
» proliferation -
» » rejuvenate vellus hair.
» »
» » I wonder if the we can obtain the “heterocyclic pyrrolopyrimidine”
» » compounds used in this study… If this bears no or minimal risk of
» » cancerous cell proliferation, then i’m sure many of us would be willing
» to
» » test this on themselves.
»
» ok, if is only accelerated growth i wonder to know why they have used the
» word “alopecia” …they have also tell PyP is simple to synthesize,
» administered orally ( though they have used shots)

actually the article says:

"we utilized a topical PyP to increase cell proliferation of cells responsible for hair production.“
and
"Bromodeoxyuridine […] was injected on days 4 and 5 to identify proliferating cells.”.

Bromodeoxyuridine is a synthetic nucleoside used to observe cell proliferation by incorporating Bromodeoxyuridine into the DNA of the newly generated cells, instead of thymidine. The proliferated cells can then be identified using specific antibodies. So this was merely used to gain information and understanding of the cell proliferation process, while the PyP compound was applied topically.


#14

» » » » well, the first thing to ask them is: Are they speaking of regrowth
» » or
» » » » only
» » » » of accelerated growth? I don’t understand if those mice were
» » partially
» » » » bald or not before shaving.
» » »
» » » from what i understand, they simply shaved mice and accelerated the
» » hair
» » » growth. They also stated that the newly grown hair, not only grew
» very
» » » rapidly, but it also was dark black as opposed to the original hair
» » which
» » » had been black with some grey hair. I presume if this compound works
» » the
» » » same way on human hair, then it wld cause rapid hair growth along
» with
» » » increased pigmentation and probably - due to increased cell
» » proliferation -
» » » rejuvenate vellus hair.
» » »
» » » I wonder if the we can obtain the “heterocyclic pyrrolopyrimidine”
» » » compounds used in this study… If this bears no or minimal risk of
» » » cancerous cell proliferation, then i’m sure many of us would be
» willing
» » to
» » » test this on themselves.
» »
» » ok, if is only accelerated growth i wonder to know why they have used
» the
» » word “alopecia” …they have also tell PyP is simple to synthesize,
» » administered orally ( though they have used shots)
»
» actually the article says:
»
» “we utilized a topical PyP to increase cell proliferation of
» cells responsible for hair production.”

» and
» “Bromodeoxyuridine […] was injected on days 4 and 5 to identify
» proliferating cells.”
.
»
» Bromodeoxyuridine is a synthetic nucleoside used to observe cell
» proliferation by incorporating Bromodeoxyuridine into the DNA of the newly
» generated cells, instead of thymidine. The proliferated cells can then be
» identified using specific antibodies. So this was merely used to gain
» information and understanding of the cell proliferation process, while the
» PyP compound was applied topically.

You have right. The solution is also very simple… ethanol only? Is enough to have transdermal absorption? Ok, we need more informations on the PyP’s effects.