[quote][postedby]Originally Posted by roger_that[/postedby]
The more I look at all the evidence and take in the big picture, the more convinced I am than ever, that there will be NO non-cell based treatment which can effectively cure MPB.
By “no non-cell based cure” I mean:
– no topicals of ANY kind (no growth factors, no Histogen, no Follica, no AAPE or other cell-derivatives, no anti-FGF5, no PGD2 inhibitor)
– no wounding treatment of ANY kind, with topicals or without
– no plucking treatment of ANY kind
– no Pilox, no laser comb, no electric field, no exotic chemical or nutrient-based treatment
– no “cosmetic” substance rolled out by some shady or never-before-seen firm somewhere in the world
– no amazing discovery involving some everyday substance or activity that just somehow escaped being discovered by humans for 3000 years of recorded history
– no pill or drug of ANY kind
– no “parsimonious” miracle treatment like addressing lymph blockages or hanging people upside-down or any of those pie-in-the-sky “weird science” ideas professed by armchair eccentric hair loss “boffins” and amateur scientists
The MOST that even the best of any of the above will be able to do is produce sparse, sporadic hair or peach fuzz. None of the above will help anyone whose hair loss is not very recent or slight. There will be no miraculous “aha” chemical or drug of any kind that will grow truly substantial amounts of cosmetically viable hair on a mostly-bald scalp. You might as well get a hair transplant – the results will suck, they may tear up portions of your scalp, but it will still probably look better than any of the above.
The ONLY candidate for a REAL cure to MPB is one thing: a cell-based treatment, where newly-grown cells are added to the scalp. In this way, brand new follicles can and will be created in any quantities we need. It’s also the only realistic hope we have of reviving miniaturized follicles with any degree of certainty.
ONLY adding new cells to the scalp – meaning inductive Dermal Papilla cells (Drs Christiano and Jahoda), or inductive DP-like cells grown from pluripotent stem cells (Dr Terskikh and Sanford-Burnham), or other related research (e.g., Drs Lauster and Lindner in Berlin) will offer any REALISTIC hope for the 90% of us on these boards who are suffering from REAL, advanced hair loss, not just minor thinning. A related idea is growing new follicles in vitro, which Dr Lauster’s team and some scientists in Japan are working on.
Many people on these forums are constantly deluding themselves, always putting hope in “next” chemical or drug or product that suddenly appears on the market, or in the research pipeline. There’s always a huge buzz and much hype about these products, but the real results never pan out.
When people buy these chemicals and products online and test this stuff on themselves, it never works.
When clinical trials are actually done of these chemicals and drugs and treatments, the best they ever show is minimal, incidental hair growth which is not substantially more than what a placebo would produce. Even if it does seem to grow more hair – as in the case of products like Histogen – it’s obvious that it won’t restore a full head of hair on the vast majority of people, and it’s obvious that these products, if used in the massive dosages that might actually produce significant regrowth, can be quite toxic to the system.
I suggest that if you have significant hair loss – not just minor thinning – you start to change your thinking and don’t get excited about every new drug or chemical or topical that comes along.
The most these things will be able to do, in the VERY BEST CASE SCENARIO, is grow some peach fuzz or sporadic new hairs. But you’ll still have a lot of scalp to cover after that, after these products reach their inevitable biochemical plateaus.
And don’t wait for FDA approval or legalization of any of these chemicals anywhere in the world, either. What I am saying refers to such products whether approved by the FDA and other regulatory authorities, or not. It is inconsequential whether or not they’re approved. Even treatments which mostly suck, like Minoxidil, have been approved almost everywhere in the world. So don’t get your hopes up. Don’t think that FDA approval somehow means a product will actually work well. On the other hand, don’t assume that because a product is not FDA approved yet, it’s really so great that you just have to get your hands on it, because it’ll regrow all your hair. You will NOT regrow your head of hair using chemicals, government approved or not.
There is a paradox with many of these products – in theory, they could grow substantial amounts of hair, but to reach that point, you have to have so much of the product in your system, that it becomes toxic. And there you have the ultimate Catch-22.
I repeat: the ONLY real hope for a CURE to hair loss we will see, is going to be a cell-based treatment, where newly-grown cells are actually put, implanted, or injected into your skin.
There is really no other realistic way ahead.[/quote]
I disagree… the scientists who did the plucking believe they can locate a molecule that signals the pathway that their plucking hit.
Of course, multiplying a million follicles and implanting them is ideal, but there may be a way to rejuvinate follices other ways… see my posts on s.aga for examples