Very Informative Article by Dr. Cotsarelis

Stem cell; cell based hair therapy
1

http://www.uphs.upenn.edu/dermatol/faculty/pdf/TrendsMolMed.pdf

Haven’t read this anywhere before, so posting the link. Very detailed and informative article about various forms of hairloss, and talks about current understanding of androgentic alopecia. Also, mentions various pathways involved/activated during various stages of hairgrowth.

I believe understanding these pathways and when to activate which one would definitely help us in refining the Follica, at home, experiments.

2

» http://www.uphs.upenn.edu/dermatol/faculty/pdf/TrendsMolMed.pdf
»
» Haven’t read this anywhere before, so posting the link. Very detailed and
» informative article about various forms of hairloss, and talks about
» current understanding of androgentic alopecia. Also, mentions various
» pathways involved/activated during various stages of hairgrowth.
»
» I believe understanding these pathways and when to activate which one
» would definitely help us in refining the Follica, at home, experiments.

Interesting is that image where it desceibes the fibrous tract that is created bellow the follicle when catagen happens in androgenetic alopecia.

I googled it and several other articles mention it. So its probably why the miniaturized follicles are so hard to reverse.

One thing that I can think of is effects of honey on the scarred skin (it reverses scarring, I succesfully usd it to almost completely get rid of quite large scar I had on my cheek, it would probably vanish completely if I kept applying it, but after I became virtually invisible, I kinda could not be bothered anymore with the honey mess).

The other idea I’m playing with is using a needle to damage the tissue bellow the dermis & the dermis itself. A kind of stick the needle in a bit and then make a circle aproach.

3

I’m planning on reading this paper when I’ll have some sufficient free time. Nice picture, this is a state of the art paper, now we need all this knowledge to materialize into a cure.

Debris,

Nothing noteworthy with the Progesterone+Dutasteride Combo ???

4

» … after I became virtually invisible, …

scary :smiley:

5

» I’m planning on reading this paper when I’ll have some sufficient free
» time. Nice picture, this is a state of the art paper, now we need all this
» knowledge to materialize into a cure.
»
» Debris,
»
» Nothing noteworthy with the Progesterone+Dutasteride Combo ???

I have 10-20 terminal hair in my temples that this combo grew in, and loads of vellus hair that seems still to be turning into terminal. In fact I have been just thinking that it is worth taking picture now. I should have a picture thats old 4 months or so, when I started. I will take another one at some point and will post it here. Its not a quick cure, but it grows terminal hair in temples that have been bald for ages now. So far I’m not aware of anything else that powerful in temple area.

6

» » … after I became virtually invisible, …
»
» scary :smiley:

a typo :slight_smile: it should have read:

“… after it became virtually invisible, …”

of course :slight_smile:

7

» One thing that I can think of is effects of honey on the scarred skin (it
» reverses scarring, I succesfully usd it to almost completely get rid of
» quite large scar I had on my cheek, it would probably vanish completely if
» I kept applying it, but after I became virtually invisible, I kinda could
» not be bothered anymore with the honey mess).

I also found fibrous tract info very interesting. Actually, the other day when I was searching for garlic based hair loss remedies, I came across this link: http://ezinearticles.com/?Garlic-Based-Hair-Loss-Remedy&id=302731

It has both garlic & honey in it. Along with aloe gel (anti-inflammatory), chamomile (anti-fungal) and egg yolks. The woman who wrote claims that she tried everything and nothing worked for her, then she tried this and within 1-2 months she grew her hair back. I was planning on trying garlic juice (EnterTheDragon on another forum is having success with it). Now knowing more about fibrous tract and honey, I’ll mix some honey in it as well and see what happens.

Btw, how bad was your scar? did you apply honey during wounding healing/scar formation or a while after the scar had been formed? can you also tell me the exact procedure & duration for which you applied honey (once a day, once a week etc). I also have a scar that I need to take care of.

8

» » One thing that I can think of is effects of honey on the scarred skin
» (it
» » reverses scarring, I succesfully usd it to almost completely get rid of
» » quite large scar I had on my cheek, it would probably vanish completely
» if
» » I kept applying it, but after I became virtually invisible, I kinda
» could
» » not be bothered anymore with the honey mess).
»
» I also found fibrous tract info very interesting. Actually, the other day
» when I was searching for garlic based hair loss remedies, I came across
» this link:
» http://ezinearticles.com/?Garlic-Based-Hair-Loss-Remedy&id=302731
»
» It has both garlic & honey in it. Along with aloe gel (anti-inflammatory),
» chamomile (anti-fungal) and egg yolks. The woman who wrote claims that she
» tried everything and nothing worked for her, then she tried this and within
» 1-2 months she grew her hair back. I was planning on trying garlic juice
» (EnterTheDragon on another forum is having success with it). Now knowing
» more about fibrous tract and honey, I’ll mix some honey in it as well and
» see what happens.
»
» Btw, how bad was your scar? did you apply honey during wounding
» healing/scar formation or a while after the scar had been formed? can you
» also tell me the exact procedure & duration for which you applied honey
» (once a day, once a week etc). I also have a scar that I need to take care
» of.

my scar has been very deep and scattered, around 3.5 cm long, but jiggy a lot and sunken in. I first had an excision repair job done, this was not satisfying at all, my father commented on it as wasted money, because the scar ended up literarly the same as it was, even though after the excision repair I had been applying loads of pretty expensive crap the doc’s recommended. another 3 years later (EDIT: doh actually when thinking about it, its almost 6 years, the time goes away quicker I think) with literarly the same sunken ugly jiggy scar on my cheek, I read some home remedy forum and they mentioned honey for scars. I tried that. After 2 weeks I could tell its working because the hard surrounding tissue around the sunken part, started to be significantly softer. After around 2 months the scar was almost gone. It is still there and it is visible, but only if you look for it, and as I said, I still think that I could apply more honey to it and it would still be improving. I’m just too lazy to do it because its literarly unnoticeable now anyway. All I did was applying honey, and when I noticed that the tissue gets softer, I was pressing onto it to help it break down. BTW the scar was not only sunken but also whitish and now it’s normal looking, the same colour my skin tone is.

9

and try it on the scalp.

10

» my scar has been very deep and scattered, around 3.5 cm long, but jiggy a
» lot and sunken in. I first had an excision repair job done, this was not
» satisfying at all, my father commented on it as wasted money, because the
» scar ended up literarly the same as it was, even though after the excision
» repair I had been applying loads of pretty expensive crap the doc’s
» recommended. another 3 years later (EDIT: doh actually when thinking about
» it, its almost 6 years, the time goes away quicker I think) with literarly
» the same sunken ugly jiggy scar on my cheek, I read some home remedy forum
» and they mentioned honey for scars. I tried that. After 2 weeks I could
» tell its working because the hard surrounding tissue around the sunken
» part, started to be significantly softer. After around 2 months the scar
» was almost gone. It is still there and it is visible, but only if you look
» for it, and as I said, I still think that I could apply more honey to it
» and it would still be improving. I’m just too lazy to do it because its
» literarly unnoticeable now anyway. All I did was applying honey, and when I
» noticed that the tissue gets softer, I was pressing onto it to help it
» break down. BTW the scar was not only sunken but also whitish and now it’s
» normal looking, the same colour my skin tone is.

I’ll give honey a try on my scar as well. So how did you use it, just wash face everynight and apply it before going to bed? Also, you said it was a sunken scar? has it filled in now and leveled or is it still sunken?

11

He needs to confirm that but he once told me that he did that honey treatment 3 months after he got wounded.

As for the study, the picture 4 and 5 got my attention, the fig4 shows the difference between reversible and non reversible hair loss. The fig 5 talks about an Unknown (not identified yet) signal (in green) necessary for hair genesis, I guess this is one important piece of the puzzle toward a cure.

Someone tried steroids / Prendisone ???

12

Isn’t that article over 7 yrs old.

13

» Isn’t that article over 7 yrs old.

Yes, Still a lot of information given in that article is NOT available commonly on the Internet. That’s why I posted it as an Informative article for people who wanna understand hairloss a bit more.

14

» » my scar has been very deep and scattered, around 3.5 cm long, but jiggy
» a
» » lot and sunken in. I first had an excision repair job done, this was
» not
» » satisfying at all, my father commented on it as wasted money, because
» the
» » scar ended up literarly the same as it was, even though after the
» excision
» » repair I had been applying loads of pretty expensive crap the doc’s
» » recommended. another 3 years later (EDIT: doh actually when thinking
» about
» » it, its almost 6 years, the time goes away quicker I think) with
» literarly
» » the same sunken ugly jiggy scar on my cheek, I read some home remedy
» forum
» » and they mentioned honey for scars. I tried that. After 2 weeks I could
» » tell its working because the hard surrounding tissue around the sunken
» » part, started to be significantly softer. After around 2 months the
» scar
» » was almost gone. It is still there and it is visible, but only if you
» look
» » for it, and as I said, I still think that I could apply more honey to
» it
» » and it would still be improving. I’m just too lazy to do it because its
» » literarly unnoticeable now anyway. All I did was applying honey, and
» when I
» » noticed that the tissue gets softer, I was pressing onto it to help it
» » break down. BTW the scar was not only sunken but also whitish and now
» it’s
» » normal looking, the same colour my skin tone is.
»
» I’ll give honey a try on my scar as well. So how did you use it, just wash
» face everynight and apply it before going to bed? Also, you said it was a
» sunken scar? has it filled in now and leveled or is it still sunken?

I did exactly what you described, sometimes when I didn’t go out I applied it even during the day. And it has leveled yes, filled in, and the edges flattened.

15

» He needs to confirm that but he once told me that he did that honey
» treatment 3 months after he got wounded.
»

I have not done anything 3 months after I got wounded, because I got wouned when I was around I dunno, 8 years old? :slight_smile:

I got wounded 20 years ago. so you must be confusing me with someone perhaps.

16

» I did exactly what you described, sometimes when I didn’t go out I applied
» it even during the day. And it has leveled yes, filled in, and the edges
» flattened.

ok, I just tried some honey. Dman that stuff is thick, probably thicker than tar! It’s funny all the time I ate honey, never really noticed it’s texture but when I was trying to apply it on my scar it was like trying to get a monkey to sit down quitely. Anywho, I will try it for 2-3 weeks and see what happens. Are you gonna start applying the honey to your temples?

17

» » I did exactly what you described, sometimes when I didn’t go out I
» applied
» » it even during the day. And it has leveled yes, filled in, and the
» edges
» » flattened.
»
» ok, I just tried some honey. Dman that stuff is thick, probably thicker
» than tar! It’s funny all the time I ate honey, never really noticed it’s
» texture but when I was trying to apply it on my scar it was like trying to
» get a monkey to sit down quitely. Anywho, I will try it for 2-3 weeks and
» see what happens. Are you gonna start applying the honey to your temples?

yeah I wil try that for sure, I just get some honey now, which may take few days because I’m working most of the day, and too lazy to drive far away to a groceries that are not closed at night.

Massage the honey in. I also few times did use the honey to make a slight peel, as I applied it, the skin got sticky, so I used my finger pressed it onto the sticky surface of my scar and then pulled out quickly (the idea was to get the sunken scar surface to level out.

Anyway just experiment, but all in all you should see if its working in 14 days or less. thats what it took for me.