» There is nothing wrong. In fact, it is good because this will tell us what
» is the real state of ARI’s research.
» Well, there is a little problem for ARI: if the trials are not
» satisfactory, the japanese will pull the plug, and Aderans Research
» Institute will die. That would explain why ARI is resorting to a “desperate
» measure” to get results.
» Again, this is a risky theory, but very possible.
… but it’s a damn good “theory”. In fact, it’s the truth.
It’s NOT my intention to confuse anyone here, but FACT IS FACT.
To give you just some short HINTS …
Aderans seems to not be working, or they wouldn’t have grown their Phase II study - they’re trying new techniques because their first one didn’t work well enough.
Right or wrong?
Let’s assume, YOU are “Dr. Ken Washenik” – ok?
One day, your BIG BOSS (the one, who is paying you your salary AND your research in general) forced you to show them your approaches/findings/outcome for what they have paid, after a period of time. In fact, after 8 years (!)
The very best place to show your outcome/status, would be in front of
- your BIG BOSS in general;
- shareholders particularly;
So there (in fact, in the headquarters in Tokyo) you’re forced to show them the very first human trail results, to CONVINCE your BOSS & interested shareholders:
Clinical Trail Summary to Date (10 June 2010)
Just for the record:
A small comparison with Histogen’s results …
Anyway, THESE few pics above show you just the reality – the reality WITHOUT any skin pre-stimulation with Minoxidil!
» Good post, here’s a little part of the Follica patent where
» they mention using Minox as well.
@Rev:In a particular embodiment of the methods, kits, and compositions of the invention, the EGFR inhibitor is administered, formulated, or is part of a kit with an anti-androgen (e.g., finasteride) and
a channel opener (e.g., minoxidil).
These companies are using it to help their method work better,
I don’t know why that is such a big deal to be honest.
That’s because it isn’t such a big deal.
EXCERPT of the relevant study by Aderans:
It was surprising to us not only that dissociated trichogenic cells rapidly reform follicles but that the newly
formed follicles cycle, and moreover that the newly formed follicle cycle has a period very close, if not exactly matching, the cycle of the derivative follicles.
The phenomenon of hair cycling appears to be inherent in the structure of the follicle; in other words, if a follicle forms, it will cycle—the cycling trait seems to be inherent in the follicle structure itself. In an incidental observation, it was of interest to notice that the formation and cycling of the reformed follicles occurred independent of the host follicle cycle.
Since early studies indicated that the whole skin organ is affected and changes with each phase of the cycle (Chase et al, 1953; Hansen et al, 1984), it was not clear whether telogen skin could support anagen follicle growth.
If telogen epidermis actually does produce an inhibitor to anagen growth, then that inhibitor may not diffuse long enough distances (Paus,et al, 1990) to reach the cells in the patch reaction (Gurdon,1989).
So now the big QUESTION:
What happens if you pre-stimulate (~6 – 12 month) your scalp SKIN with Minoxidil (2%) BEFORE your get ARI’s cell-based procedure - eh?
In my personal opinion, Histogen’s very first results are A KIND of “proof of concept” of ARI’s approach with the Minox protocol.
That means, if you are able to rejuvenate BOTH, skin & follicle cells, resp. if you are able to convert/re-program every RELEVANT cell type in your scalp with help of a special protein complex, you may be able to get easier better results - besides the fact, that there is NO NEED for a small biopsy one or two month before such a cell-based procedure like Aderans’, and there would be NO NEED for a usage of Minoxidil as well AND besides the BIG fact, that such a procedure, like Histogen’s HSC, may be MUCH less expensive in general and much more “patient-convenient” too.
But be assured, BOTH approaches (ARI’s & Histogen’s) will reach satisfying results in general.