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Something to chew on


#1

Hair Follicle Stem Cells Provide a Functional Niche for Melanocyte Stem Cells

http://www.cell.com/cell-stem-cell/retrieve/pii/S193459091000651X


#2

» Hair Follicle Stem Cells Provide a Functional Niche for Melanocyte Stem
» Cells
»
» http://www.cell.com/cell-stem-cell/retrieve/pii/S193459091000651X

Dont get me wrong but right now i really think that a lot of botech firms have found hairloss as a nice money making thing.

I bet my a+s we have a solution in 3 years. Holy cow they are really running like hell here. Now i begin to understand why some surgeons go the Acell way.

Thanks Khalil


#3

» Hair Follicle Stem Cells Provide a Functional Niche for Melanocyte Stem
» Cells
»
» http://www.cell.com/cell-stem-cell/retrieve/pii/S193459091000651X

Basically -more accurate “unfortunately”- there is nothing to “chew on”:

Summary
In most stem cell systems, the organization of the stem cell niche and the anchoring matrix required for stem cell maintenance are largely unknown. We report here that collagen XVII (COL17A1/BP180/BPAG2), a hemidesmosomal transmembrane collagen, is highly expressed in hair follicle stem cells (HFSCs) and is required for the maintenance not only of HFSCs but also of melanocyte stem cells (MSCs), which do not express Col17a1 but directly adhere to HFSCs. Mice lacking Col17a1 show premature hair graying and hair loss. Analysis of Col17a1-null mice revealed that COL17A1 is critical for the self-renewal of HFSCs through maintaining their quiescence and immaturity, potentially explaining the mechanism underlying hair loss in human COL17A1 deficiency. Moreover, forced expression of COL17A1 in basal keratinocytes, including HFSCs, in Col17a1-null mice rescues MSCs from premature differentiation and restores TGF-β signaling, demonstrating that HFSCs function as a critical regulatory component of the MSC niche.

Source: http://www.cell.com/cell-stem-cell/retrieve/pii/S193459091000651X

Some hours ago, I posted this:
http://www.hairsite.com/hair-loss/forum_entry-id-79290-page-0-category-1-order-last_answer.html


Discussion/Conclusion
Through its restricted expression and corepressor function, HR controls the timing and location of hair follicle regeneration. Although the connection between HR and Wnt signaling is strong, hair follicle regeneration is a complex process requiring coordination of multiple signaling pathways, including Shh and BMPs (45). Molecular mechanisms underlying potential crosstalk between signaling pathways during hair follicle regeneration are not known. Notably, Wise has also been shown to function as a modulator of BMP signaling (26–28). It is likely that HR regulates the expression of multiple genes important for follicle regeneration, which may include modulators of other signaling pathways.

Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1253615/

So, WHERE is the difference concerning the different researchers commonly conclusions - about 5 years apart?

On the other hand, EVERY finding is a finding - even it is numerously and in different ways concluded, that “hair growth and hair follicle formation is a complex subject …”


#4

To make it short. The more informations the better. PERIOD